| 1 | Composite B-cell and T-cell lymphomas:clinical,pathological,and molecular features of three cases and literature review显示文摘Composite lymphoma(CL)involving B-cell lymphoma and T-cell lymphoma is extremely rare.Herein,we report three such cases using immunohistochemistry,flow cytometry,and the next-generation sequencing(NGS)to identify the pathological and molecular characteristics of CL.In the first case,the patient was admitted to hospital for generalized pruritic maculopapular rash over the whole body.An excisional biopsy of the skin lesions showed T-cell lymphoma.At the same time,the staging bone marrow(BM)biopsy revealed a diffuse large B-cell lymphoma(DLBCL).After R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine,and prednisone)therapies,the patient produced a good response with substantial dissipation of the rashes and relief of skin.The other two patients were admitted to hospital due to lymphadenopathy and were diagnosed with DLBCL and follicular lymphoma(FL)after core needle biopsy of lymph nodes,BM biopsy,BM aspiration,and flow cytometry.Following R-CHOP and R-COP(rituximab,cyclophosphamide,vincristine,and prednisone)therapies,they achieved complete remission unconfirmed(CRu)and complete remission(CR).However,one or two years later,they suffered a relapse of lymphadenopathy.The shocking fact was that re-biopsy of lymphadenopathy revealed peripheral T-cell lymphoma(PTCL)and angioimmunoblastic T-cell lymphoma(AITL).NGS findings identified DNA methyltransferase 3a(DNMT3a),isocitrate dehydrogenase 2(IDH2),Ras homolog gene family,member A(RHOA),splicing factor 3B subunit 1(SF3B1),and tumor protein p53(TP53)mutations.After immunochemotherapy,these patients achieved CRu and CR again.Nevertheless,they suffered a second relapse of T-cell lymphoma.Finally,they died due to progression of disease.We found that the occurrence of CL is associated with Epstein-Barr virus infection and DNMT3a,IDH2,and TP53 mutations,and the prognosis of the disease is closely related to the T-cell lymphoma components. | Xueli JIN Hui LIU Jing LI Xibin XIAO Xianggui YUAN Panpan CHEN Boxiao CHEN Yun LIANG Fengbo HUANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，8： | 0 |
| 2 | A hybrid-order local search algorithm for set k-cover problem in wireless sensor networks显示文摘1 Introduction The lifetime of wireless sensor networks(WSNs)is restricted by the limited energy of battery-powered sensor devices,making the lifetime extension a critical problem in real applications[1].Several aspects have been examined in previous works to extend the lifetime of WSNs,such as the deployment position,the network routing strategy and the sensing range adjustment.Given the fact that there are often many redundant sensors,a practical way to extend the lifetime of a WSN is to partition the sensors into subsets,each of which can cover all the targets[2].Then the sets are activated one by one,extending the lifetime of a WSN to times of the battery lifetime of a sensor.The problem of finding the maximal is abstracted as the set k-cover problem. | Boxiao LIU Mengting YUAN Haihang YOU | 2023 | Frontiers of Computer Science2023，17，3： | 0 |
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