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| 1 | A Facile One-Step Synthesis of TiOe/Graphene Composites for Photodegradation of Methyl Orange显示文摘 | Haijiao Zhang Panpan Xu Guidong Du Zhiwen Chen Kokyo Oh Dengyu Pan Zheng Jiao | 2011 | Nano Research2011，4，3： | 21 |
| 2 | Establishment of pseudovirus infection mouse models for in vivo pharmacodynamics evaluation of filovirus entry inhibitors显示文摘Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4(BSL-4) facilities, which have restricted the development of anti-filovirus vaccines and drugs.An HIV-based pseudovirus cell infection assay is widely used for viral entry studies in BSL-2 conditions. Here,we successfully constructed nine in vitro pseudo-filovirus models covering all filovirus genera and three in vivo pseudo-filovirus-infection mouse models using Ebola virus, Marburg virus, and Lloviu virus as representative viruses. The pseudo-filovirus-infected mice showed visualizing bioluminescence in a dose-dependent manner. A bioluminescence peak in mice was reached on day 5 post-infection for Ebola virus and Marburg virus and on day4 post-infection for Lloviu virus. Two known filovirus entry inhibitors, clomiphene and toremiphene, were used to validate the model. Collectively, our study shows that all genera of filoviruses can be well-pseudotyped and are infectious in vitro. The pseudo-filovirus-infection mouse models can be used for in vivo activity evaluation of anti-filovirus drugs. This sequential in vitro and in vivo evaluation system of filovirus entry inhibitors provides a secure and efficient platform for screening and assessing anti-filovirus agents in BSL-2 facilities. | Qing Chen Ke Tang Xiaoyu Zhang Panpan Chen Ying Guo | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 10 |
| 3 | Concurrent chemoradiotherapy comparison of taxanes and platinum versus 5-fluorouracil and platinum in nasopharyngeal carcinoma treatment显示文摘 | Chen Xichuang Hong Yuan Feng Jinhua Ye Jianlin Zheng Panpan Guan Xiyin You Xiaohong Song Huizhu | 2014 | Chinese Medical Journal2014，，1： | 8 |
| 4 | Increased leptin by hypoxic-preconditioning promotes autophagy of mesenchymal stem cells and protects them from apoptosis显示文摘Autophagy is the basic catabolic progress involved in cell degradation of unnecessary or dysfunctional cellular components.It has been proven that autophagy could be utilized for cell survival under stresses.Hypoxic-preconditioning(HPC)could reduce apoptosis induced by ischemia and hypoxia/serum deprivation(H/SD)in bone marrow-derived mesenchymal stem cells(BMSCs).Previous studies have shown that both leptin signaling and autophagy activation were involved in the protection against apoptosis induced by various stress,including ischemia-reperfusion.However,it has never been fully understood how leptin was involved in the protective effects conferred by autophagy.In the present study,we demonstrated that HPC can induce autophagy in BMSCs by increased LC3-II/LC3-I ratio and autophagosome formation.Interestingly,similar effects were also observed when BMSCs were pretreated with rapamycin.The beneficial effects offered by HPC were absent when BMSCs were incubated with autophagy inhibitor,3-methyladenine(3-MA).In addition,down-regulated leptin expression by leptin-shRNA also attenuated HPC-induced autophagy in BMSCs,which in turn was associated with increased apoptosis after exposed to sustained H/SD.Furthermore,increased AMP-activated protein kinase phosphorylation and decreased mammalian target of rapamycin phosphorylation that were observed in HPC-treated BMSCs can also be attenuated by down-regulation of leptin expression.Our data suggests that leptin has impact on HPC-induced autophagy in BMSCs which confers protection against apoptosis under H/SD,possibly through modulating both AMPK and mTOR pathway. | WANG LiHan HU XinYang ZHU Wei JIANG Zhi ZHOU Yu CHEN PanPan WANG JianAn | 2014 | Science China(Life Sciences)2014，57，2： | 8 |
| 5 | Association of cystatin C level and cardiovascular prognosis for patients with preexisting coronary heart disease:a meta-analysis显示文摘The association of circulating levels of cystatin C(CysC)and risk of recurrent cardiovascular events in patients with preexisting coronary heart disease are uncertain.To qualitatively and quantitatively address this issue,we performed a random meta-analysis of results from prospective studies on the topic.We searched electronic and printed sources(up to 16 October 2011)using keywords and retrieved articles for seven prospective studies according to the selection criteria.Data were abstracted and meta-analysis was performed using the random-effects model(RevMan 5.0.23 software).The cohorts involved 4,576 patients with preexisting coronary heart disease(CHD)and normal or mild chronic kidney disease,and follow-up ranged from 5.6 to 40.6 months.Highest versus lowest baseline CysC level was significantly associated with increased risk of cardiovascular events(OR 2.30,95%CI 1.80–2.94),all-cause mortality(OR 5.69,95%CI 3.70–8.74),but not with recurrent MI(OR 1.75,95%CI 0.77–4.00).In heterogeneity testing for studies reporting cardiovascular events and all-cause mortality,no significant heterogeneity was found,and exclusion of any single study did not alter the overall finding.For risk of recurrent MI,significant heterogeneity was found among the five trials(v2=13.16,P=0.01,I2=70%)and exclusion of the Taglieri et al.[12]study from the analysis resulted in a rise in relative risk(OR 2.36,95%CI 1.09–5.15).In conclusion,for patients with established CHD,high baseline level of CysC is associated with increased risk of cardiovascular events and all-cause death during long-term follow-up. | Ruijian Li Panpan Hao Yuguo Chen Yun Zhang | 2014 | Chinese Science Bulletin2014，59，5： | 8 |
| 6 | G protein-coupled receptor 183 facilitates endothelial-to- hematopoietic transition via Notch1 inhibition显示文摘 | Panpan Zhang Qiuping He Dongbo Chen Weixiao Liu Lu Wang Chunxia Zhang Dongyuan Ma Wei Li Bing Liu Feng Liu | 2015 | Cell Research2015，25，10： | 7 |
| 7 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 8 | Performance projections for ballistic carbon nanotube FinFET at circuit level显示文摘为碳 nanotube (CNT ) 的新奇三维的设备结构鳍地效果晶体管(FinFET ) 被建议并且评估。我们包括繁殖延期,全部的力量驱散,和精力延期产品(电子数据处理) 用三个表演度量标准在电路水平在一个 22-nm 节点与 Si FinFET 相比评估了 CNT FinFET 的潜力。与 Si FinFET 相比, CNT FinFET 处于在更高全部的功率驱散从它的几乎更大的当前的密度而且结果产生的速度和电子数据处理介绍明显的优点,特别在低阀值电压(V th = 1/3V dd ) 。在 V th 能有效地贡献漏电流和力量驱散的重要抑制,然后明显的优化处于速度与可接受的牺牲在 EDP 被获得。特别地,有优化阀值电压的 CNT FinFETs 能在低供应电压下面在 Si FinFETs 上提供约 50 次的一个电子数据处理优点(V dd = 0.4 V ) ,为 CNT 基于 FinFET 的集成电路建议大潜力。 | Panpan Zhang Chenguang Qiu Zhiyong Zhang Li Ding Bingyan Chen Lianmao Peng | 2016 | Nano Research2016，9，6： | 6 |
| 9 | Mapping stripe rust resistance genes by BSR-Seq:YrMM58 and YrHY1 on chromosome 2AS in Chinese wheat lines Mengmai 58 and Huaiyang 1 are Yr17显示文摘Stripe rust(yellow rust), caused by Puccinia striiformis f. sp. tritici(PST),is one of the most devastating fungal diseases in common wheat(Triticum aestivum L.) in China and worldwide. Resistance breeding is the most effective strategy to control diseases in crop plants. Chinese wheat lines Mengmai 58 and Huaiyang 1 are highly resistant to PST race CYR34(V26) at the adult plant stage. To genetically map the underlying resistance genes we developed segregating populations by crossing Mengmai 58 and Huaiyang 1 with the susceptible cultivar Nongda 399. The stripe rust resistances in Mengmai 58 and Huaiyang 1 were both controlled by single dominant genes, provisionally designated YrMM58 and YrHY1, respectively. Bulked segregant RNA-Seq(BSR-Seq) analysis showed that YrMM58 and YrHY1 were located in the same distal ~16 Mb region on chromosome 2 AS.Comparative genomics analysis with the physical map of Aegilops tauschii proved useful for developing additional markers to saturate the genetic linkage map. YrMM58 and YrHY1 were mapped to the distal end of chromosome arm 2 AS, with the closest marker WGGB148 being 7.7 cM and 3.8 cM from the resistance gene, which was considered to be Yr17. These markers can be used in marker-assisted selection. | Yong Wang Huaizhi Zhang Jingzhong Xie Bingmin Guo Yongxing Chen Huaiyu Zhang Ping Lu Qiuhong Wu Miaomiao Li Deyun Zhang Guanghao Guo Jian Yang Panpan Zhang Yan Zhang Xicheng Wang Hong Zhao Tingjie Cao Zhiyong Liu | 2018 | The Crop Journal2018，6，1： | 5 |
| 10 | A novel selective autophagy receptor,CCDC50,delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection显示文摘Autophagy is a con served process that delivers cytosolic substa nces to the lysosome for degradatio n,but its direct role in the regulation of antiviral inn ate immu nity remains poorly un derstood.Here,through high-throughput screeni ng,we discovered that CCDC50 functions as a previously unknown autophagy receptor that negatively regulates the type I interferon(IFN)signaling pathway initiated by RIG-I-like receptors(RLRs),the sensors for RNA viruses.The expression of CCDC50 is enhanced by viral infection,and CCDC50 specifically recognizes K63-polyubiquitinated RLRs,thus delivering the activated RIG-I/MDA5 for autophagic degradation.The associatio n of CCDC50 with phagophore membrane protei n LC3 is con firmed by crystal structure analysis.In contrast to other known autophagic cargo receptors that associate with either the LIR-docking site(LDS)or the UIMdocking site(UDS)of LC3,CCDC50 can bind to both LDS and UDS,representing a new type of cargo receptor.In mouse models with RNA virus infection,CCDC50 deficiency reduces the autophagic degradation of RIG-I/MDA5 and promotes type I IFN responses,resulting in enhaneed viral resistance and improved survival rates.These results reveal a new link between autophagy and antiviral innate immune resp on ses and provide additional in sights into the regulatory mecha nisms of RLR-mediated antiviral signaling. | Panpan Hou Kongxiang Yang Penghui Jia Lan Liu Yuxin Lin Zibo Li Jun Li Shuliang Chen Shuting Guo Ji'An Pan Junyu Wu Hong Peng Weijie Zeng Chunmei Li Yingfang Liu Deyin Guo | 2021 | Cell Research2021，31，1： | 5 |
| 11 | Geochronological Records of Oil-Gas Accumulations in the Permian Reservoirs of the Northeastern Ordos Basin显示文摘油气体累积(OGA ) 的地球年代学是在多周期的石油地质学的一个挑战性的题目附加的盆。由 K-Ar, authigenic illite (AI ) 和液体包括(FI ) 分析标明日期与磷灰石分裂轨道结合了(在船尾) 热建模,在东北 Ordos 盆(击) 抑制二叠的水库的 OGA 时间的案例研究在这份报纸被进行了。二叠的 oil-gas-bearing 沙岩核心样品标明日期的 AI 显示出 178108 妈的一个宽时间领域。AI 年龄的分发介绍主要 OGA 在二叠的水库处理的 2 阶段,它分别地与 165 妈和 130 妈的 2 山峰年龄在 175155 妈和 145115 妈的时间域发展了。现在二组织与的在船尾热的路径上的样品和他们的投射年龄的 FI 温度山峰不仅一低并且一座高山峰在 9078hallow 地下水的范围的温度能满足国家标准。(2 ) 从 coalbed 生产的水主要包含了 NaCl 獲漠 ? 慗整 ? 潃牰摯 ' 讚攥?潃污敢 ? 慇? 湡 ? 桓污潬 ? 片畯摮慷整 ? 湩 ? 畩楬? 潃污楦汥? 景 ? | CHEN Gang YANG Fu LI Shuheng ZHANG Huiruo HU Yanxu LEI Panpan | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 4 |
| 12 | Preferential adsorption behaviour of CH_4 and CO_2 on high-rank coal from Qinshui Basin,China显示文摘In order to better understand the prevailing mechanism of CO2 storage in coal and estimate CO2 sequestration capacity of a coal seam and enhanced coalbed methane recovery(ECBM) with CO2 injection into coal, we investigated the preferential adsorption of CH4 and CO2on coals. Adsorption of pure CO2,CH4 and their binary mixtures on high-rank coals from Qinshui Basin in China were employed to study the preferential adsorption behaviour. Multiple regression equations were presented to predict CH4 equilibrium concentration from equilibrium pressure and its initial-composition in feed gas. The results show that preferential adsorption of CO2 on coals over the entire pressure range under competitive sorption conditions was observed, however, preferential adsorption of CH4 over CO2on low-volatile bituminous coal from higher CH4-compostion in source gas was found at up to 10 MPa pressure. Preferential adsorption of CO2 increases with increase of CH4 concentration in source gas, and decreases with increasing pressure. Although there was no systematic investigation of the effect of coal rank on preferential adsorption, there are obvious differences in preferential adsorption of gas between low-volatile bituminous coal and anthracite. The obtained preferential adsorption gives rise to the assumption that CO2 sequestration in coal beds with subsequent CO2-ECBM might be an option in Qinshui Basins, China. | Yu Hongguan Jing Renxia Wang Panpan Chen Lihui Yang Yongjie | 2014 | International Journal of Mining Science and Technology2014，24，4： | 4 |
| 13 | Purification of starch and phosphorus wastewater using core-shell magnetic seeds prepared by sulfated roasting显示文摘Core-shell magnetic seeds with certain adsorption capacity that were prepared by sulfated roasting, served as the core of a magnetic separation technology for purification of starch wastewater. XRD and SEM results indicate that magnetite's surface transformed to be porous α-Fe_2O_3 structure. Compared with magnetite particles, the specific surface area was significantly improved to be 8.361 from 2.591 m^2/g, with little decrease in specific susceptibility. Zeta potential, FT-IR and XPS experiments indicate that both phosphate and starch adsorbed on the surface of the core-shell magnetic seeds by chemical adsorption, which fits well with the Langmuir adsorption model. The porous surface structure of magnetic seeds significantly contributes to the adsorption of phosphate and starch species, which can be efficiently removed to be 1.51 mg/L(phosphate) and 9.51 mg/L(starch) using magnetic separation. | Chunjie Du Jinsheng Yu Wei Sun Haisheng Han Yuehua Hu Pan Chen Panpan Hou Runqing Liu Li Wang Yue Yang Ruohua Liu Lei Sun | 2019 | Journal of Environmental Sciences2019，31，7： | 4 |
| 14 | Biosynthesis and molecular engineering of templated natural products显示文摘Bioactive small molecules that are produced by living organisms, often referred to as natural products(NPs), historically play a critical role in the context of both medicinal chemistry and chemical biology. How nature creates these chemical entities with stunning structural complexity and diversity using a limited range of simple substrates has not been fully understood. Focusing on two types of NPs that share a highly evolvable ‘template'-biosynthetic logic, we here provide specific examples to highlight the conceptual and technological leaps in NP biosynthesis and witness the area of progress since the beginning of the twenty-first century. The biosynthesis of polyketides, non-ribosomal peptides and their hybrids that share an assembly-line enzymology of modular multifunctional proteins exemplifies an extended ‘central dogma'that correlates the genotype of catalysts with the chemotype of products; in parallel, post-translational modifications of ribosomally synthesized peptides involve a number of unusual biochemical mechanisms for molecular maturation. Understanding the biosynthetic processes of these templated NPs would largely facilitate the design, development and utilization of compatible biosynthetic machineries to address the challenge that often arises from structural complexity to the accessibility and efficiency of current chemical synthesis. | Ming Chen Jingyu Liu Panpan Duan Mulin Li Wen Liu | 2017 | National Science Review2017，4，4： | 4 |
| 15 | CD70-targeting CAR-T cells have potential activity against CD19-negative B-cell Lymphoma显示文摘To the Editor:CD19-targeting chimeric antigen receptor T(CAR-T)cell therapy is a revolutionary immunotherapy in treating relapsed or refractory B lineage malignancies.However,relapse with CD19-negative tumor after treatment with anti-CD19 CAR-T cells has been reported in different types of B-cell lymphoid malignancies,with a percentage exceeding 10% in patients with acute lymphoblastic leukemia[1]and up to 38% in patients with non-Hodgkin lymphoma(NHL)[2]. | Wenhai Deng Panpan Chen Wen Lei Yang Xu Nengwen Xu Jeffrey J.Pu Aibin Liang Wenbin Qian | 2021 | Cancer Communications2021，41，9： | 4 |
| 16 | Ionic Liquid as a Precursor to Synthesize Nitrogen- and Sulfur-co-doped Carbon Dots for Detection of Copper(II) Ions显示文摘 | XU Panpan WANG Chunfeng SUN Dong CHEN Yujuan ZHUO Kelei | 2015 | Chemical Research in Chinese Universities2015，31，5： | 3 |
| 17 | Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence显示文摘Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity remains unknown. An LC/MS-based lipidomic analysis of PANC-1,MDA-MB-231, HCT-116 and A549 cancer cells was conducted after siRNA depletion of CPT1C. Cellular lipotoxicity was further confirmed by lipotoxicity assays. Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. This was coincident with changes in expressions of mRNAs involved in lipogenesis.Histological and biochemical analyses revealed higher lipid accumulation and increased malondialdehyde and reactive oxygen species, signatures of lipid peroxidation and oxidative stress. Reduction of ATP synthesis, loss of mitochondrial transmembrane potential and down-regulation of expression of mitochondriogenesis gene m RNAs indicated mitochondrial dysfunction induced by lipotoxicity, which could further result in cellular senescence. Taken together, this study demonstrated CPT1C plays a critical role in the regulation of cancer cell lipotoxicity and cell senescence, suggesting that inhibition of CPT1C may serve as a new therapeutic strategy through induction of tumor lipotoxicity and senescence. | Huizhen Zhang Yongtao Wang Lihuan Guan Yixin Chen Panpan Chen Jiahong Sun Frank J.Gonzalez Min Huang Huichang Bi | 2021 | Journal of Pharmaceutical Analysis2021，11，3： | 3 |
| 18 | Mapping a leaf senescence gene els1 by BSR-Seq in common wheat显示文摘Leaf senescence is normally the last stage of plant development. Early senescence of functional leaves significantly reduces the photosynthetic time and efficiency, seriously affecting grain yield and quality in wheat. Discovering genes responsible for early leaf senescence(els) are necessary for developing novel germplasms and cultivars with delayed leaf-senescence through molecular manipulation and marker assisted selection. In this study, we identified an early leaf senescence line M114 in a derivative of a wheat breeding population. Genetic analysis indicated that early leaf senescence in M114 is controlled by a single recessive gene, provisionally designated els1. By applying bulked segregant analysis and RNA-Seq(BSR-Seq), seven polymorphic markers linked to els1 were developed and the gene was located on chromosome arm 2 BS in a 1.5 c M genetic interval between markers WGGB303 and WGGB305. A co-segregating marker, WGGB302, provide a starting point for fine mapping and map-based cloning of els1. | Miaomiao Li Beibei Li Guanghao Guo Yongxing Chen Jingzhong Xie Ping Lu Qiuhong Wu Deyun Zhang Huaizhi Zhang Jian Yang Panpan Zhang Yan Zhang Zhiyong Liu | 2018 | The Crop Journal2018，6，3： | 3 |
| 19 | Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5显示文摘Dear Editor,Psoriasis is a common immune mediated,chronic inflammatory skin disease,which has been characterized by epidermal acanthosis,hyperkeratosis,parakeratosis and extensive infiltration of inflammatory cell.KCs have critical roles in skin innate and adaptive immune responses during the development of psoriasis,which produce large amounts of inflammatory mediators,such as antimicrobial peptides(e.g.,S100A8,9),proinflammatory cytokines(e.g,IL-6,IL-17A,C,TNF-α,)and chemokines(e.g,CXCL1,2),triggering innate or adaptive immune responses. | Li lei Bei Yan Panpan Liu Jie Li Chao Chen Wu Zhu Yehong Kuang Xiang Chen Cong Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 20 | An artificial chromosome for data storage显示文摘DNA digital storage provides an alternative for information storage with high density and long-term stability.Here,we report the de novo design and synthesis of an artificial chromosome that encodes two pictures and a video clip.The encoding paradigm utilizing the superposition of sparsified error correction codewords and pseudo-random sequences tolerates base insertions/deletions and is well suited to error-prone nanopore sequencing for data retrieval.The entire 254 kb sequence was 95.27%occupied by encoded data.The Transformation-Associated Recombination method was used in the construction of this chromosome from DNA fragments and necessary autonomous replication sequences.The stability was demonstrated by transmitting the data-carrying chromosome to the 100 th generation.This study demonstrates a data storage method using encoded artificial chromosomes via in vivo assembly for write-once and stable replication for multiple retrievals,similar to a compact disc,with potential in economically massive data distribution. | Weigang Chen Mingzhe Han Jianting Zhou Qi Ge Panpan Wang Xinchen Zhang Siyu Zhu Lifu Song Yingjin Yuan | 2021 | National Science Review2021，8，5： | 3 |
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