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| 1 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 2 | Effect of SiC particals on the microstructure of the alumina matrix nanocomposites显示文摘 | Gao L Brandon D G | 1998 | J Inorg Mater1998，13，4： | 1 |
| 3 | Evaluation of human milk fortification from the time of the first feeding: effects on infants of less than 31 weeks gestational age 显示文摘 | TILLMAN S BRANDON D H SILVA S G | 2012 | J Perinatol2012，32，7： | 1 |
| 4 | Preterm infants born at less than 31 weeks' gestation have improved growth in cycled light compared with continuous near darkness 显示文摘 | Brandon D H Holditch D D Belyea M | 2002 | J Pediatr2002，140，： | 1 |
| 5 | Control of texture in monolithic alumina 显示文摘 | BRANDON D CHEN D CHAN H | 1995 | Materials Science & Engineering A1995，195，12： | 1 |
| 6 | Conservingtropical biodiversity amid weak institutions 显示文摘 | Barrett C B Brandon K Gibson C Gjertsen H | 2001 | BioScience2001，51，6： | 1 |
| 7 | A novel approach to process modeling for instrument surveillance and calibration verification 显示文摘 | BRANDON R WESLEY H ROBERT E U | 2003 | Nuclear Technology2003，，2： | 1 |
| 8 | A novel approach to process modeling for instrument surveillance and calibration verification显示文摘 | BRANDON R WESLEY H ROBERT E U | 2003 | Nuclear Technology2003，，2： | 1 |
| 9 | PTPN22 genetic variation: evidence for multiple variants associated with rheumaloid arthritis显示文摘 | Carlton V E Hu X Chokkalingam A P Schrodi S J Brandon R Alexander H C | 2005 | Am J Hum Genet2005，77，： | 1 |
| 10 | Motions or muscles Some behavioral factors underlying robotic assistance of motor recovery显示文摘 | Neville H Hermano I K Brandon | 2006 | The Journal of Rehabilitation Research & Development2006，43，5： | 1 |
| 11 | On the effects of variations in the design parameters on the dynamic performance of machine tool spindle-bearing systems显示文摘 | AL-SHAREEF K J H BRANDON J A | 1990 | International Journal of Machine Tools & Manufacture1990，30，3： | 1 |
| 12 | Special Project,self-Help:Extrajudicial Rights,Privileges and Remedies in Contemporary American Society显示文摘 | COOPER Melinde Lee GRESHIN Jeremy H | 1984 | Vanderbilt Law Review1984，，37： | 1 |
| 13 | Recent advances in materials for fuel cells 显示文摘 | BRANDON N P SKINNER S STEELE B C H | 2003 | Annu Rev Mater Res2003，33，： | 1 |
| 14 | Local recurrence after breast-conserving surgery and radiotherapy显示文摘 | Kurtz JM Amalric R Brandone H | 1989 | Cancer1989，63，： | 1 |
| 15 | Study of Loss Mechanisms Using Half- Cell Measurements in a Regenerative Hydrogen Vanadium Fuel Cell 显示文摘 | Dewage H H Yufit V Brandon N P | 2016 | J Electrochem Soc2016，163，1： | 1 |
| 16 | Modeling cylindroconical fer- menter cooling using finite element analysis 显示文摘 | BERNAS B SERVAIS R BRANDON H | 2000 | Technical quarterly- MBAA2000，37，3： | 1 |
| 17 | History andexamination in the assessment of patients with idiopathicfecal incontinence显示文摘 | Hill J Corson RJ Brandon H | 1994 | Dis Colon Rectum1994，37，5： | 1 |
| 18 | Porcine mannan-binding lectin A binds to actinobacillus snis and Hatmophilus parasuu显示文摘 | Brandon N L Jutta D H Janet I M | 2006 | Developmental and Comparative Immunology2006，30，： | 1 |
| 19 | Metabolic contributors to drought-enhanced accumulation of sugars and acids in oranges显示文摘 | BRANDON R H ETXEBERRIAN E D | 2001 | J Amer Soc Hort Sci2001，126，5： | 1 |
| 20 | Monoclonal antibody for multiresidue ELISA of benzimidazole anthelmintics in liver显示文摘 | BRANDON D L BINDER R G BATES A H | 1994 | Agr Food Chem1994，42，7： | 1 |
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