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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Hydrocompression settlement of deep fills 显示文摘 | Brandon T L Duncan J M Gardner W S | 1990 | ASCE Journal of Geotech Eng1990，116，10： | 1 |
| 3 | The effect of root pruning on the maturation of loblolly pine (Pinus taeda) plantlets, rooted hypocotyls, and seedlings显示文摘 | Wisniewski L A Brandon D L McKeand S E | 1991 | Canadian Journal of Forest Research1991，21，7： | 1 |
| 4 | Chalcogenide Glass-Fiber-Based Mid-IR Sources and Applications显示文摘 | Sanghera J S Brandon Shaw L Aggarwal I D | 2009 | IEEE Journal of Selected Topics in Quantum Electronics2009，，15： | 1 |
| 5 | Presence orthe Streptococcus suis suilysin gene and expression of MRP and EF corre- lates with high virulence in Streptococcus suis type 2 isolates 显示文摘 | Jacque J S Brandon L P George C S | 1999 | Vet Microbiol1999，70，： | 1 |
| 6 | Mono- clonal antibody to CD4 T cells abrogates genetic re- sistance to Haemonchus contortus in sheep 显示文摘 | GILL H S WATSON D L BRANDON M R | 1993 | Immu- nology1993，78，1： | 1 |
| 7 | First human-caused extinction of a cetacean species?显示文摘 | Turvey Samuel T Pitman Robert L Taylor Barbara L Barlow Jay Akamatsu Tomonari Barrett Leigh A Zhao Xiujiang Reeves Randall R Stewart Brent S Wang Kexiong Wei Zhuo Zhang Xianfeng Pusser L.T Richlen Michael Brandon John R Wang Ding | 2007 | Biology Letters2007，，5： | 1 |
| 8 | A myocyte enhancer factor 2D (MEF2D) kinase activated during neuronal apoptosis is a novel target inhibited by lithium 显示文摘 | DANIEL A L BRANDON J C SHOSHONA S L | 2003 | Journal of Neurochemistry2003，85，： | 1 |
| 9 | Rapid screening for benzimidazole residues in bovine liver显示文摘 | BRANDON D L HOLLAND K P DREAS J S HENRY A C | 1998 | J Agric Food Chem1998，46，9： | 1 |
| 10 | Inner ear supporting cells protect hair cells by secreting HSP70显示文摘 | MAY L A KRAMARENKO I I BRANDON C S | 2013 | J Clin Invest2013，123，8： | 1 |
| 11 | Underwater tempo- rary threshold shift induced by octave-band noise in three species of pinniped 显示文摘 | David Kastak Ronald J S Brandon L S | 1999 | Acoust Soc Am1999，106，2： | 1 |
| 12 | An assessment of the utility of an acoustic Doppler current profiler for biomass estimation显示文摘 | Brierley A S Brandon M A Watkins J L | 1998 | Deep Sea Research(Part Ⅰ:Oceanographic Research Papers)1998，45，9： | 1 |
| 13 | Presence of the Streptococcus suis suilysin gene and expression of MRP and EF correlates with high virulence in Streptococcussuis type 2 isolates显示文摘 | Jacque J S Brandon L P George C S | 1999 | Vet Microbiol1999，70，： | 1 |
| 14 | Presence or the Streptococcus suis suilysin gene and expression of MRP and EF correlates with high virulence in Streptococcus suis type 2 isolates 显示文摘 | Jacque J S Brandon L P George C S | 1999 | Vet Microbiol1999，70，： | 1 |
| 15 | IEEEJ Quantum Electron显示文摘 | Sanghera Jas S Brandon Shaw L Aggarwal Ishwar D | 2009 | (15): 1142009，，15： | 1 |
| 16 | Design and test of a 175-Mb/s, rate-1/2 (128,3,6) low-density paritycheck convolutional code encoder and decoder 显示文摘 | SWAMY R BATES S BRANDON T L | 2007 | IEEE Journal of Solid-State Circuits2007，42，10： | 1 |
| 17 | Presence of the Streptococcus suis suilysin gene and expression of MRP and EF correlates with high virulence in Streptococcus suis type 2 isolates显示文摘 | Jacque J S Brandon L P George C S | 1999 | Vet Microbiol1999，70，： | 1 |
| 18 | Chemical vapour deposition synthetic diamond: materials, technology and applications 显示文摘 | Balmer R S Brandon J R Clewes S L | 2009 | Journal of Physics-Condensed Matter2009，21，36： | 1 |
| 19 | Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell death显示文摘 | Cunningham L L Brandon C S | 2006 | J Assoc Res Otolaryngol2006，7，： | 1 |
| 20 | Rapaid Screening for Benzimidazole Residues in Bovine Liver 显示文摘 | Brandon D L Holand K P Dreas J S | 1998 | Journal of Agricultural and Food Chemistry1998，46，： | 1 |
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