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| 1 | Psychiatric comorbidity in the treatment of patients with inflammatory bowel disease显示文摘Ulcerative colitis and Crohn’s disease,commonly known as inflammatory bowel disease(IBD),draw attention from specialists of various disorders,including gastroenterology,psychiatry,and radiology.The involvement of a cortical influence in the brain-gut axis as well as the interaction of the hypothalamic-pituitary-adrenal axis and the peripheral nervous system provide an initial explanation of the psychological symptoms associated with IBD.The involvement of structures the limbic system,such as the anterior cingulate cortex,the prefrontal cortex,and the amygdala,paves the way for the discovery of the mechanisms underlying depression depression,anxiety,alexithymia,personality traits,and other psychological impairments following the onset of IBD.Psychiatric therapy in IBD patients is almost as important as the gastroenterological approach and consists of pharmacological treatment and psychotherapy.Neither of the available psychiatric treatment methods is considered the golden standard because both methods have side effects,and psychotropic medication can provoke the worsening of IBD symptoms.Thus,both approaches must be applied with awareness of the possibility of side effects.We suggest that psychiatrists and gastroenterologists work together to reach a consensus on IBD therapy to ensure success and to reduce side effects and relapse to the lowest possible rates. | Branislav R Filipovic Branka F Filipovic | 2014 | World Journal of Gastroenterology2014，20，13： | 9 |
| 2 | Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease显示文摘AIM: To investigate autonomic nervous function in patients with a diagnosis of gastroesophageal reflux disease(GERD).METHODS: The investigation was performed on 29patients(14 men), aged 18-80 years(51.14 ± 18.34),who were referred to our Neurocardiology Laboratory at the Clinical and Hospital Center 'Bezanijska Kosa'with a diagnosis of GERD. One hundred sixteen healthy volunteers matched in age and sex with the examinees served as the control group. The study protocol included the evaluation of autonomic function and hemodynamic status, short-term heart rate variability(HRV) analysis, 24 h ambulatory ECG monitoring with long-term HRV analysis and 24 h ambulatory blood pressure monitoring.RESULTS: Pathologic results of cardiovascular reflex test were more common among patients with reflux compared to the control group. Severe autonomic dysfunction was detected in 44.4% of patients and in7.9% of controls(P < 0.001). Parameters of short-term analysis of RR variability, which are the indicators ofvagal activity, had lower values in patients with GERD than in the control group. Long-term HRV analysis of time-domain parameters indicated lower values in patients with reflux disease when compared to the control group. Power spectral analysis of long-term HRV revealed lower low- and high-frequency values.Detailed 24 h ambulatory blood pressure analysis showed significantly higher values of systolic blood pressure and pulse pressure in the reflux group than in the control group.CONCLUSION: Patients with GERD have distortion of sympathetic and parasympathetic components of the autonomic nervous system, but impaired parasympathetic function appears more congruent to GERD. | Branislav Milovanovic Branka Filipovic Slavica Mutavdzin Marija Zdravkovic Tatjana Gligorijevic Jovana Paunovic Marina Arsic | 2015 | World Journal of Gastroenterology2015，21，22： | 4 |
| 3 | Carcinosarcoma of the stomach:A case report and review of the literature显示文摘Carcinosarcomas are rare,malignant,biphasic tumors. We report the case of a 62-year-old man with gastric carcinosarcoma,along with its clinical,macroscopic and histopathological features. Macroscopically,a specimen of deformed stomach was obtained that measured 200 mm×150 mm×100 mm. A 150 mm×100 mm× 50 mm exophytic tumoral mass (Borrmann typeⅠ) was found,which involved the posterior wall from the cardia to the antrum. Histopathologically,a mixed type of malignancy was revealed: an adenocarcinoma with intestinal metaplasia,with interposed fascicles of fusiform atypical cells and numerous large,rounded and oval cells. The tumor showed positive histochemistry for cytokeratin 18,epithelial membrane antigen,carcinoembryonic antigen,chromogranin A and vimentin. Liver metastases were diagnosed 8 mo postoperatively,and the patient died 4 mo later. A review of the available literature is also presented. | Tomislav Randjelovic Branka Filipovic Darko Babic Vesna Cemerikic Branislav Filipovic | 2007 | World Journal of Gastroenterology2007，13，41： | 3 |
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