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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Myocardial infarction as complication of left atrial myxoma 显示文摘 | Braun S Schrotter H Reynen K | 2005 | Int J Cardiol2005，101，1： | 1 |
| 3 | The use of anesthesia during evoked potential audiometry in goldfish ( Carassius auratus ) 显示文摘 | Cordova M S Braun C B | 2007 | Brain Research2007，115，： | 1 |
| 4 | Active succinate dehydrogenase (SDH) and lack of SDHD mutations in sporadic paragangliomas 显示文摘 | Braun S Riemann K Kupka S | 2005 | Anticancer Res2005，25，4： | 1 |
| 5 | A comparison of eleven static heuristics for mapping a class of independent tasks onto heterogeneous distributed computing systems显示文摘 | Braun T D Siegel H S Beck N | 2001 | Journal of Parallel and Distributed Computing2001，61，6： | 1 |
| 6 | CdS mineralization of hexagonal lamellar and cubic lyotropic liquid crystals 显示文摘 | Braun P V Stupp S I | 1999 | Mater Res Bull1999，34，3： | 1 |
| 7 | Fusion of C3d molecule with bovine rotavirus VP7 or bovine berpesvirus type 1 glycoprotein D inhibits immune responses following DNA immunization 显示文摘 | Suradhat S Braun RP Lewis PJ | 2001 | Vet Immunol Immunopathol2001，83，12： | 1 |
| 8 | Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model显示文摘 | Chen K Braun S Lyman S | 1997 | Cancer Res1997，57，16： | 1 |
| 9 | Oxidized low densi- ty lipoproteins, statin therapy and severity of coronary artery dis- ease显示文摘 | Ndrepepa G Braun S von Beckerath N | 2005 | Clin Chim Acta2005，360，12： | 1 |
| 10 | Non-linear regression model for spatial variation in precipitation chemistry for South India 显示文摘 | SIVA S B SEKItAR M RIOTTE J BRAUN J J | 2009 | Atmospheric Environment2009，43，5： | 1 |
| 11 | Elemental flux between al- gae and duckweeds (Lemna gibba) during competition 显示文摘 | Szado S Braun M Borics G | 1999 | Arch Hydmbiol1999，146，3： | 1 |
| 12 | Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation 显示文摘 | Kluge S Braune SA Engel M | 2012 | Intensive Care Med2012，38，： | 1 |
| 13 | Auricular reconstruction with porous polyethylene frameworks:outcome and patient benefit in 65 children and adults显示文摘 | Braun T Gratza S Becker S | | 0，，04： | 1 |
| 14 | Total leucocyte count,but not C-reactive protein,predicts 1-year mortality in patients with acute coronary syndromes treated with percutaneous coronary intervention显示文摘 | Ndrepepa G Braun S Iijima R | | 0，，： | 1 |
| 15 | Volume - selective l H - MR spec- troscopy for in vivo detection of valproate in patients with epilepsy 显示文摘 | Seyfert S Bernarding J Braun J | 2003 | Neuroradiology2003，45，5： | 1 |
| 16 | Production smoothing evidence from physical-product data显示文摘 | Krane S S Braun | 1991 | Journal of Political Economy1991，99，3： | 1 |
| 17 | Morphological changes of isolated rat pancreatic islets:a structural,ultrastructural and morphometric study显示文摘 | Morini S Braun M Onori P | 2006 | J Anat2006，209，3： | 1 |
| 18 | Direct MR arthrography ofthe wrist-value in detecting complete and partial defe-cts of intrin-sic ligaments and the TFCC in comparison with arthroscopy显示文摘 | Braun H Kenn W Schneider S | 2003 | Article in German2003，175，11： | 1 |
| 19 | Generalized universal Reynolds equations for variable properties fluid-film lubrification and variable geometry selfacting bearings显示文摘 | Hannon W M Braun M J Hariharan S I | 2004 | Tribology Transactions2004，47，2： | 1 |
| 20 | Skin temperature after interscalene brachial plexus blockade 显示文摘 | Hermanns H Braun S Werdehausen R | 2007 | Reg Anesth Pain Med2007，32，： | 1 |
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