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| 1 | The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition显示文摘在人的不孕病人的精子在场的最普通的损害之一是精子鸡蛋识别的自发的失败。尽管这个唯一的细胞的相互作用现在能被象 intracytoplasmic 精子注射(ICSI ) 那样的帮助繁殖策略乐意地绕过,最近的大规模流行病学的研究鼓励了这种技术的小心的使用并且为对为有缺点的精子鸡蛋识别负责的机制的进一步的研究加亮需要。这个领域里的以前的工作证实了为卵母细胞相互作用负责的精子领域在动态地在女繁殖的道在 epididymal 成熟和 capacitation 期间被修改以前在精子发生期间被形成。当为这些顺序的 maturational 事件的规定负责的因素无疑是复杂的时,新兴的研究识别了分子的女伴,加热吃惊蛋白质 A2 (HSPA2 ) ,,在人的精子的这些事件的一个关键管理者。HSPA2 是支持合拢,运输,和集会蛋白质建筑群的 70 kDa 热吃惊蛋白质家庭的一个充实睾丸的成员并且断然被相关与在 vitro 授精(IVF ) 成功。而且,从人的精子 proteome 减少了 HSPA2 的表示为跟随 IVF 和 ICSI 的积云矩阵疏开,精子鸡蛋识别和授精导致一个损害能力。在这评论,我们考虑在精子功能支持 HSPA2 的角色的证据并且探索它被在不肥沃的病人的精子弄空的潜在的机制。进管理精子的分子的机制的如此的信息提议小说卓见工作。 | Brett Nixon Elizabeth G Bromfield Matthew D Dun Kate A Redgrove Eileen A McLaughlin R John Aitken | 2015 | Asian Journal of Andrology2015，17，4： | 8 |
| 2 | Myosin binding protein C:Structural abnormalities in familial hypertrophic cardiomyopathy显示文摘The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC molecule have been assigned a function in the regulation of muscle contraction, the interaction of other regions with various parts of the myosin molecule and the sarcomeric proteins, actin and titin, remain obscure. In additic n, several intra-domain interactions between adjacent MyBPC molecules have been identified. Although the basic structure of the molecule (a series of immunoglobulin and fibronectin domains) has been elucidated, the assembly of MyBPC in the sarcomere is a topic for debate. By analysing the MyBPC sequence with respect to FHC-causing mutations it is possible to identify individual residues or regions of each domain that may be important either for binding or regulation. This review looks at the current literature, in concert with alignments and the structural models of MyBPC, in an attempt to understand how FHC mutations may lead to the disease state. | Cecily E OAKLEY Brett D HAMBLY Paul MG CURMI Louise J BROWN | 2004 | Cell Research2004，14，2： | 2 |
| 3 | A comparison of the digestibility of a range of lupin and soybean protein products when fed to Atlantic salmon (Salmo salar) or rainbow trout ( Oncorhynchus mykiss) 显示文摘 | Brett D G Chris G C Neil D | 2004 | Aquaculture2004，237，14： | 1 |
| 4 | Systematic Review of Quality of Life and Other Patient-centred Outcomes after Cardiac Arrest Survival显示文摘 | Elliott V J Rodgers D L Brett S J | 2011 | Resuscitation2011，82，3： | 1 |
| 5 | Accessory protein recruitment motifs in clathrin-mediated endocytosis 显示文摘 | BRETT T J TRAUB L M FREMONT D H | 2002 | Structure2002，10，： | 1 |
| 6 | An assessment of the total external costs of UK agriculture 显示文摘 | Pretty J N Brett C Gee D | 2000 | Agricultural Systems2000，65，2： | 1 |
| 7 | Multienzymatic synthesis of polyhydroquinon for use as a Redox Polymer显示文摘 | PING WANG BRETT D MARTIN SANGAMITRA PARIDA | 1995 | J Am Chem Soc1995，117，12： | 1 |
| 8 | Efficient transformation of scutellar tissue of immature maize embryos显示文摘 | Bretts Chneider R Becker D Lorz H | 1997 | Theor Appl Genet1997，94，： | 1 |
| 9 | Mul tienzymatic synthesis of polyhydroquinone for use as a Redox Poly mer 显示文摘 | Brett D Martin Sangamitra Parida | 1995 | JAm ChemSoc1995，117，12： | 1 |
| 10 | Alternative splicing and genome complexity 显示文摘 | Brett D Pospisil H Valcarcel J | 2002 | Nat Genet2002，30，1： | 1 |
| 11 | A comparison of theeffect of diet extrusion or screw-press pelleting on the digesti-bility of grain protein products when fed to rainbow troutj显示文摘 | Brett G D Wayne H D David E | 2011 | Aquaculture2011，312，： | 1 |
| 12 | Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus显示文摘 | Thaete C Brett D Monaghan P | 1999 | Hum Molec G enet1999，8，： | 1 |
| 13 | Missile longitudinal autopilots: Comparison of multiple three loop topotogies显示文摘 | Curtis P Mraeek D Brett R | 2005 | AIAA Guidance Navigation and Control Conference and Exhibit2005，6380，： | 1 |
| 14 | Cell culture-grown hepatitis C vires is infectious in vivo and can be recuhured in vitro 显示文摘 | Brett D Lindenbaeh Philip Meuleman Alexander Ploss | 2006 | Proc Nat! Aead Sci2006，103，10： | 1 |
| 15 | The extent and impact of sheep pox and goat pox in the state of Maharashtra,India显示文摘 | GARNER M SAWARKAR S D BRETT E K | 2000 | Trop Anlm Health Prod2000，32，4： | 1 |
| 16 | Magnetostratigraphy susceptibility of the Upper Ordovician Kope Formation, North- ern Kentucky显示文摘 | Ellwood B B Brett C E Macdonald W D | 2007 | Palaeogeography Palaeoclimatology Palaeo- ecology2007，243，12： | 1 |
| 17 | A Calcite Permeable Reactive Barrier for the Remediation of Fluoride from Spent Potliner (SPL) Contaminated Groundwater显示文摘 | Brett D Turner Philip J Binning Scott W Sloan | 2008 | Journal of Contaminant Hydrology2008，95，34： | 1 |
| 18 | Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals 显示文摘 | Yellin MJ Brett J Baum D | 1995 | J Exp Med1995，182，6： | 1 |
| 19 | The type II O-antigenic polysaccharide moiety of Burkholderia pseudomallei li- popolysaccharide is required for serum resistance and virulence显示文摘 | DESHAZER D BRETT P J WOODS D E | 1998 | Mol Microbiol1998，30，： | 1 |
| 20 | Functional interactions of T cells with endothelial cells the role of sCD40L-CD40-mediated signals显示文摘 | Yellin MJ Brett J Baum D | 1995 | Exp Med1995，182，6： | 1 |
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