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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett’s oesophagus: a prospective study显示文摘 | Thomas L Vaughan Linda M Dong Patricia L Blount Kamran Ayub Robert D Odze Carissa A Sanchez Peter S Rabinovitch Brian J Reid | 2005 | Lancet Oncology2005，，12： | 2 |
| 3 | Predictors of progression in Barrett’s esophagus III: baseline flow cytometric variables显示文摘 | Peter S Rabinovitch Gary Longton Patricia L Blount Douglas S Levine Brian J Reid | 2001 | The American Journal of Gastroenterology2001，，11： | 2 |
| 4 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 5 | Antifouling enzymes and the biochemistry of marine settlement显示文摘 | Jakob B K Rikke L M Brian S L | 2008 | Biotechn Adv2008，26，： | 1 |
| 6 | Postharvest 显示文摘 | Christian C Jim S Brian L | 2000 | Biology and Technology2000，，19： | 1 |
| 7 | Low-temperature polyol synthesis of AuCuSn2 and AuCuSn2:using solution chemistry to access ternary intermetallic compounds as nanocrystals显示文摘 | Brian M L Nattamai S P B Raymond E S | 2005 | JACS2005，，： | 1 |
| 8 | A review of chromatographic methods for the assessment of phospholipids in biological samples 显示文摘 | Brianna L P Brian S C | 2006 | Biomedical Chromatography2006，20，： | 1 |
| 9 | Tooth wear and culture:A survey of tooth functions among some prehistoric populations显示文摘 | Molnar S Barrett MJ Brian L | 1972 | Current Anthropology1972，13，5： | 1 |
| 10 | Preparation of n-tosylaldimines显示文摘 | BRIAN E L PRASAD S R THOMAS C W | 1994 | Synlett1994，，： | 1 |
| 11 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 12 | Constraints on the acquisition of remanent magnetization in fine-grained sediments imposed by redeposition experiments显示文摘 | BRIAN C S JEAN P V MAXIME L G | 2006 | Earth and Planetary Science Letters2006，245，： | 1 |
| 13 | Substrate-assisted catalysis in sialic acid aldolase 显示文摘 | Brian J S Michael C L Joao A R G B | 1999 | J Org Chem1999，64，： | 1 |
| 14 | Cytoreductive Surgery with Intraperitoneal Hyperthermic Chemotherapy for advanced Cancer显示文摘 | Jason J H Brian W L Parry S | 2004 | The Society for Surgery of the Alimentary Tract2004，8，4： | 1 |
| 15 | Molecular characterization and sex- specific tissue expression of prolactin, somatolactin andinsulin-like growth factor-I in yellow perch(Percaflavescens) 显示文摘 | SCOTT G L BRIAN S S | 2007 | Comparative Biochemistry and Physiology2007，，147： | 1 |
| 16 | Effect of feed restriction on adipose tissue transcript concentrationsin genetically lean and obese pigs显示文摘 | McNeel R L Ding S T O'Brian Smith E et ol | 2000 | J Anim Sci2000，78，： | 1 |
| 17 | Rehabilitation of executive functioning after focal damage to the cerebellum显示文摘 | Tom A S Brian L Dmytro R | 2008 | Neurorehabil Neural Repair2008，22，： | 1 |
| 18 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated β-laetam resistance显示文摘 | Keith A S Misty B Brian L M | 2007 | J Biol Chem2007，282，21： | 1 |
| 19 | Development of integrated intelligent transportation systems 显示文摘 | BRIAN L S WILLIAM T S | 1999 | Trans on Research Record1999，6，4： | 1 |
| 20 | Comparison of Parametric and Nonpara-metric Models for Traffic Flow Forecasting 显示文摘 | Brian L S | 2002 | Transportation Research2002，10，4： | 1 |
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