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| 1 | 中国高龄老人健康状况和死亡率变动趋势显示文摘文章对'中国老年健康影响因素跟踪调查'近两万名80~105岁高龄老人的数据分析发现,社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被'救'存活率提高,使2008年高龄老人客观量测的躯体功能和认知功能比10年前显著下降;这给社会和亿万家庭带来严峻挑战。研究表明,经济社会发展和人类寿命提高带来效益的同时,也会产生一定成本;但它不是以往不少国际文献解释这一现象时所称的'胜利的失败',所以没有必要为此恐慌,而需要全社会积极应对,努力实现人口健康老龄化。 | 曾毅 冯秋石 Therese Hesketh Kaare Christensen James W.Vaupel | 2017 | 人口研究2017，41，4： | 53 |
| 2 | 急性心肌梗死医疗保险患者介入治疗与药物治疗强度区域变化对远期预后的影响显示文摘背景:与药物治疗比较,急性心肌梗死(acute myocardial infarction,AMI)患者介入治疗强度存在显著的地区差异,这种差异在卫生及政策方面的意义还不清楚。目标:评价接受积极治疗患者的相关临床特征;评估居住于积极采取介入治疗策略地区的AMI患者与居住于积极采取药物治疗策略地区的患者相比,是否具有更好的远期生存率。设计、地点及患者:在158831例老年医疗保险患者中进行该项全国性队列研究。患者于1994~1995年因首次发生并确诊AMI而入院,随访7年(平均随访3.6年)。根据居住地区介入治疗(30天内接受心导管手术)与药物治疗(出院时对适宜的患者应用β-阻滞剂)强度进行分析。基线资料来自心血管协作项目,并与医疗保险管理资料联合。主要观察指标:7年随访期间的远期生存率。结果:各地区AMI基线严重程度相似。在所有地区,较年轻、较健康的患者与年老的高危患者相比,更可能接受介入治疗和药物治疗。更多实施介入治疗的地区具备更多的心脏导管室条件;这些地区的患者无论年龄、临床指征还是危险特点如何,均更多接受介入治疗。介入和药物治疗策略采用率最高的地区与介入和药物治疗采用率最低的地区,两者未经校正的7年绝对生存率差异为6.2%。对于ST抬高和非ST抬高AMI患者,其生存率随着地区介入治疗和药物治疗强度的增高而升高。在药物治疗比例较高的地区,随着介入治疗的增加,相应的生存率提高很少甚或没有提高。结论:老年医疗保险AMI患者接受较为积极的药物治疗对改善人群的生存有益。 | Therese A. Stukel F. Lee Lucas David E. Wennberg 王淑敏(译) 胡大一(校) | 2005 | 美国医学会杂志(中文版)2005，24，4： | 15 |
| 3 | 中国的独生子女政策与家庭理想子女数、子女性别偏好和出生性别比:国家计划生育和生殖健康调查结果显示文摘目的分析中国独生子女政策对人口生育率、理想子女数和出生性别比的影响。资料2001年国家计划生育委员会在中国大陆31个省、自治区、直辖市进行了计划生育/生殖健康抽样调查。实际调查访问15~49岁育龄妇女39585人,调查有效率为98.3%。结果在39585名妇女中,共有73202次怀孕,活产56830个婴儿。35岁以上妇女(n= 17078)的生育率是1.94,其中,城市地区1.43,农村2.11;35岁以下妇女(n=11543)的生育率是1.73,城乡分别是1.25和1.79。出生性别比从1980至1989年的1.11上升到1996至2001年的1.23,平均为1.15。小型家庭的妇女大多是年龄较轻,受教育程度较高的城市妇女。35%的妇女喜欢一个孩子,57%的喜欢两个,多数妇女的理想子女数为1~2个孩子。结论实行人口控制政策后,出生率已经下降,大多数妇女的理想子女数也减少,但是,人口出生性别比却出现了不平衡。 | 屈坚定 Hesketh Therese | 2006 | 英国医学杂志中文版2006，9，4： | 13 |
| 4 | 雅漾舒护活泉水对1050例敏感性皮肤和炎症性皮肤病辅助治疗作用的初步观察显示文摘目的:观察雅漾舒护活泉水对敏感性皮肤和炎症性皮肤病的作用。方法:对1050例敏感性皮肤和炎症性皮肤病急性期的受试者进行观察,在门诊就诊时喷雾1次,5min后观察效果,以后每天喷雾2~3次。455例受试者单独使用雅漾舒护活泉水,595例受试者活泉水与糖皮质激素软膏及抗组胺药联合应用。结果:治疗15d后所有患者的红斑、脱屑、瘙痒等症状均有明显改善,单用雅漾舒护活泉水组和联合用药组疗效差异无显著性(P>0.05)。结论:雅漾舒护活泉水对敏感性皮肤和炎症性皮肤病具有良好的辅助治疗和护理作用。 | 潘炜华 廖万清 温海 刘玮 沈新 Sophie Vitse Therese Nocera | 2005 | 临床皮肤科杂志2005，34，7： | 13 |
| 5 | Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery显示文摘Pomegranate fruit peel is rich in bioactive plant natural products,such as hydrolyzable tannins and anthocyanins.Despite their documented roles in human nutrition and fruit quality,genes involved in natural product biosynthesis have not been cloned from pomegranate and very little sequence information is available on pomegranate in the public domain.Shotgun transcriptome sequencing of pomegranate fruit peel cDNA was performed using RNA-Seq on the Illumina Genome Analyzer platform.Over 100 million raw sequence reads were obtained and assembled into 9,839 transcriptome assemblies (TAs) (>200 bp).Candidate genes for hydrolyzable tannin,anthocyanin,flavonoid,terpenoid and fatty acid biosynthesis and/or regulation were identified.Three lipid transfer proteins were obtained that may contribute to the previously reported IgE reactivity of pomegranate fruit extracts.In addition,115 SSR markers were identified from the pomegranate fruit peel transcriptome and primers were designed for 77 SSR markers.The pomegranate fruit peel transcriptome set provides a valuable platform for natural product biosynthetic gene and SSR marker discovery in pomegranate.This work also demonstrates that next-generation transcriptome sequencing is an economical and effective approach for investigating natural product biosynthesis,identifying genes controlling important agronomic traits,and discovering molecular markers in non-model specialty crop species. | Nadia Nicole Ono Monica Therese Britton Joseph Nathaniel Fass Charles Meyer Nicolet Dawei Lin Li Tian | 2011 | Journal of Integrative Plant Biology2011，53，10： | 12 |
| 6 | 城乡青少年焦虑和抑郁症状调查显示文摘通过对浙江省城市和农村中学生焦虑症和抑郁症水平的调查问卷发现 :有高达 70 %的中学生有较多的焦虑 ,其中 ,4 8%表示焦虑是由于生活并无多少乐趣 ,2 7%是睡眠障碍。生活在农村和有兄弟姐妹者有更严重的症状。不论是在城市或农村地区 ,焦虑的主要原因都与学校相关。 6 8%是学校的学习问题、 4 4%为家庭作业问题、 51 %和离校后的就业有关。女生中有 1 / 3的人受严重抑郁症状困扰 。 | 屈坚定 余星池 高伟娜 Therese Hesketh | 2003 | 青年研究2003，，1： | 11 |
| 7 | 昆明地区孕产妇、医务人员HIV母婴垂直传播相关知识、态度对比分析显示文摘为了解孕妇及医务人员对HIV母婴垂直传播的知识、态度 ,为开展孕产妇宣传教育 ,开展阻断母婴垂直传播自愿检测、咨询及药物治疗提供依据。采用问卷对昆明地区 2 38名孕产妇及 2 2 7名医务人员进行了HIV母婴传播相关知识、态度及行为的调查。结果发现 :昆明地区大部分孕产妇及医务人员了解并认识艾滋病相关认识 ,赞同将HIV检测列入婚检、产前检查 ,并自愿接受检测。但医务人对阻断母婴垂直传播知识了解甚少 ,还存在歧视HIV感染者现象 ,临床服务中存在较高职业危险暴露行为。建议逐步在婚检、产前检查中试行HIV自愿检测 ,加强医务人员对HIV垂直传播及HIV职业暴露防护的知识技能培训 ,尽快在重点地区探索开展降低孕产妇HIV垂直传播模式。 | 李勤 朵林 毛辉 安启贤 毕海燕 李洪 裘素玲 Therese Hesketh | 2003 | 卫生软科学2003，17，4： | 9 |
| 8 | Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects显示文摘Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained women.Methods: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 mL/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 mL/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and questionnaires.Results: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p < 0.001), and incremental treadmill test performance(11.5%, p = 0.003), but not total fat mass(p = 0.176),mean arterial blood pressure(p = 0.328), resting HR(p = 0.219), or blood lipids(p = 0.298—0.854). In CG, no changes were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p < 0.001) and in the well-being subscale 'energy'(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women. | Therese Hornstrup Johan M.Wikman Bjorn Fristrup Susana Povoas Eva W.Helge Signe H.Nielsen Jorn W.Helge Jesper L.Andersen Lars Nybo Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 8 |
| 9 | Physical activity, obesity and gastroesophageal reflux disease in the general population显示文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) 'high' (several times/week); (2) 'intermediate' (approximately once weekly); and (3) 'low' (1-3 times/mo or less). Analyses were stratified for participants with 'normal weight' (BMI < 25 kg/m 2 ), 'overweight' (BMI 25 to ≤ 30 kg/m 2 ) and 'obese' (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after adjustment for potential confounding factors, neither intermediate (OR: 1.30, 95% CI: 0.75-2.26) nor high (OR: 0.99, 95% CI: 0.62-1.60) frequency of physical activity was followed by decreased risk of GERD. Sleeping problems and high comorbidity were identified as potential confounders. Among the 1859 overweight participants, crude point estimates indicated no increased or decreased risk of GERD among individuals with intermediate or high frequency of physical activity, compared to low frequency. After adjustment for confounding, neither intermediate (OR: 0.75, 95% CI: 0.46-1.22) nor high frequency of physical activity were followed by increased or decreased risk of GERD compared to low frequency among nonobese participants. Sleeping problems and high comorbidity were identified as potential confounders for overweight participants. In obese individuals, crude ORs were similar to the adjusted ORs and no particular confounding factors were identified. Intermediate frequency of physical activity was associated with a decreased occurrence of GERD compared to low frequency of physical activity (adjusted OR: 0.41, 95% CI: 0.22-0.77). CONCLUSION: Intermediate frequency of physical activity might decrease the risk of GERD among obese individuals, while no influence of physical activity on GERD was found in non-obese people. | Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren | 2012 | World Journal of Gastroenterology2012，18，28： | 8 |
| 10 | 云南省4个地区780名孕产妇预防HIV/AIDS母婴垂直传播知识态度调查显示文摘目的 了解云南省艾滋病病毒 (HIV)不同流行地区孕妇时艾滋病 (AIDS)的知识、态度及行为 ,为开展宣传教育、阻断母婴垂直传播自愿咨询、检测提供依据。方法 选择省、地区、县不同地理分布 ,孕妇HIV感染率高、中、低的 4个地区孕产妇为调查对象 ,用问卷调查表收集关于AIDS ,特别是母婴垂直传播有关的知识、态度及行为方面资料。结果 4个地区共调查 780名孕产妇 ,其中 6 41人听说过AIDS ,占 82 2 %,有关三种传播途径的正确回答率为 5 5 0 %~ 83 7%,但 73%的孕产妇认为日常生活中共餐、接吻、握手或入厕等会传播 ,37 2 %的人对婚前性行为的观念表示接受 ,77 2 %~ 81 8%的孕产妇认为婚检及产前检查中应加入HIV检测 ,91 4%的孕产妇愿意医生为其提供有关HIV知识宣传 ;83 6 %~ 84 5 %孕产妇愿意接受人工流产术、剖腹产及降低垂直传播的药物治疗。6 2 1%的孕产妇认识到安全套可预防AIDS传播。结论 孕产妇对AIDS的认识比较低 ,但愿意积极参与降低HIV垂直传播的工作。应加强预防AIDS宣传教育 ,特别是尽快在重点地区探索开展降低孕妇HIV垂直传播的工作 ,以预防AIDS的母婴垂直传播。 | 朵林 李洪 毛辉 安启贤 李勤 李慧英 康有然 杨光远 杨文跃 马丽萍 支国华 Therese Hesketh | 2003 | 中国艾滋病性病2003，9，2： | 7 |
| 11 | 细胞色素C电化学反应的静电作用模型显示文摘首次发现,简单的阴离子Ⅰ^-是细胞色素c电化学反应的良好促进剂。在碘离子修饰的金电极上能观察到细胞色素c的准可逆电化学反应。根据细胞色素c的结构特点和碘离子的吸附特性,提出了一个以静电作用为基础的细胞色素c的电化学反应的模型。 | 陆天虹 周成立 叶淑玉 于秀娟 董绍俊 Therese M.Cotton | 1992 | 分析测试通报1992，11，5： | 5 |
| 12 | Bone mineral density in lifelong trained male football players compared with young and elderly untrained men显示文摘Purpose: The purpose of the present controlled cross-sectional study was to investigate proximal femur and whole-body bone mineral density(BMD), as well as bone turnover profile, in lifelong trained elderly male football players and young elite football players compared with untrained age-matched men.Methods: One hundred and forty healthy, non-smoking men participated in the study, including lifelong trained football players(FTE, n = 35)aged 65—80 years, elite football players(FTY, n = 35) aged 18—30 years, as well as untrained age-matched elderly(UE, n = 35) and young(UY,n = 35) men. All participants underwent a regional dual-energy X-ray Absorptiometry(DXA) scan of the proximal femur and a whole-body DXA scan to determine BMD. From a resting blood sample, the bone turnover markers(BTMs) osteocalcin, carboxy-terminal type-1 collagen crosslinks(CTX-1), procollagen type-1 amino-terminal propeptide(P1NP), and sclerostin were measured.Results: FTE had 7.3%—12.9% higher(p < 0.05) BMD of the femoral neck, wards, shaft, and total proximal femur in both legs compared to UE,and 9.3%—9.7% higher(p < 0.05) BMD in femoral trochanter in both legs compared to UY. FTY had 24.3%—37.4% higher(p < 0.001) BMD in all femoral regions and total proximal femur in both legs compared to UY. The whole-body DXA scan confirmed these results, with FTE showing similar whole-body BMD and 7.9% higher(p < 0.05) leg BMD compared to UY, and with FTY having 9.6% higher(p < 0.001) wholebody BMD and 18.2% higher(p < 0.001) leg BMD compared to UY. The plasma concentration of osteocalcin, CTX-1, and P1NP were 29%,53%, and 52% higher(p < 0.01), respectively, in FTY compared to UY.Conclusion: BMD of the proximal femur and whole-body BMD are markedly higher in lifelong trained male football players aged 65—80 years and young elite football players aged 18—30 years compared to age-matched untrained men. Elderly football players even show higher BMD in femoral trochanter and leg BMD than untrained young despite an age difference of 47 years. | Marie Hagman Eva Wulff Helge Therese Hornstrup Bjorn Fristrup Jens Jung Nielsen Niklas Rye Jorgensen Jesper Lovind Andersen Jorn Wulff Helge Peter Krustrup | 2018 | Journal of Sport and Health Science2018，7，2： | 5 |
| 13 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 14 | 细胞色素c在咔唑修饰的金电极上的直接电化学显示文摘在生物体内,细胞色素c是一种电子载体,它能进行可逆的氧化还原反应,但在金属电极上的电化学反应却不可逆。1977年,Hill研究组发现,在4,4′-联吡啶存在时,细胞色素c在金电极上能进行准可逆的电化学反应。4,4′-联吡啶在细胞色素c电化学反应的过程中不起氧化还原反应而被称为促进剂。Hill等对50多种有机化合物的促进作用进行评价后提出,能加速细胞色素c电化学反应速率的促进剂分子至少应具有两个功能团。 | 周成立 曲晓刚 陆天虹 董绍俊 Therese M.Cotton | 1993 | 应用化学1993，10，4： | 5 |
| 15 | Hospital Volume and Late Survival After Cancer Surgery显示文摘 | John D. Birkmeyer Yating Sun Sandra L. Wong Therese A. Stukel | 2007 | Annals of Surgery2007，，5： | 4 |
| 16 | 大鼠高架十字迷宫中的行为表现及海马GluR1蛋白水平的性别差异显示文摘目的:探讨雌雄性SD大鼠在高架十字迷宫中各臂的探索时间及其海马内的GluR1蛋白水平是否存在性别差异。方法:将11只雄性和10只雌性SD大鼠放在高架十字迷宫中测试5min,30min后快速取出测试大鼠的两侧海马,在-80℃冰箱保存,然后提取蛋白质,用Western印迹方法检测海马内GluR1的蛋白水平。结果:与雄性大鼠相比,雌性大鼠在高架十字迷宫中表现出较轻的焦虑(P<0.05)。雌性大鼠海马总的GluR1水平及左侧海马GluR1水平比雄性大鼠低(P<0.05)。结论:SD大鼠在高架十字迷宫中的行为学表现以及海马内GluR1蛋白水平存在性别差异。 | 向小军 郝伟 Therese A.Kosten | 2011 | 中南大学学报(医学版)2011，36，8： | 4 |
| 17 | Does ethnicity and education influence preoperative disability and expectations in patients undergoing total knee arthroplasty?显示文摘AIM To investigate whether minority ethnicity and the duration of education influence preoperative disability and expectations in patients undergoing total knee arthroplasty.METHODS We prospectively included 829 patients undergoing primary unilateral total knee arthroplasty(TKA) from April 2013 to December 2014 at a single centre. Patients filled in pre-operative questionnaires with information regarding place of birth, duration of education, expectations for outcome of surgery and baseline characteristics. Patients were stratified based on ethnicity. Majority ethnicity was defined as born inthe study country and minority ethnicity was defined as born in any other country. Similarly, patients were stratified based on duration of education in groups defined as < 9 years, 9-12 years and > 12 years, respectively.RESULTS We found that 92.2% of patients were of majority ethnicity. We found that 24.5%, 44.8% and 30.8% of patients had an education of < 9 years, 9-12 years and > 12 years, respectively. The mean preoperative(preOP) oxford knee score(OKS) in the total population was 23.6. Patients of minority ethnicity had lower mean pre-OP OKS(18.6 vs 23.9, P < 0.001), higher pain levels(VAS 73.0 vs 58.7, P < 0.001), expected higher levels of post-OP pain(VAS 14.1 vs 6.1, P = 0.02) and of overall symptoms(VAS 16.6 vs 6.4, P = 0.006). Patients with > 12 years education had lower mean pre-OP OKS(21.5 vs 23.8 and 24.6, P < 0.001) and higher pre-OP VAS pain(65.4 vs 59.2 and 56.4, P < 0.001) compared to groups with shorter education. One year post-operative(post-OP) patients of minority ethnicity had lower mean OKS, higher pain and lower QoL. One year post-OP patients with > 12 years education reported higher pain compared to patients with shorter educations. However, the response-rate was low(44.6%), and therefore post-OP results were not considered to be significant.CONCLUSION Minority ethnicity and the duration of education influ-ence preoperative disability and expectation in patients undergoing TKA. This should be taken into account when patients are advised pre-operatively. | Madeline Therese Kudibal Thomas Kallemose Anders Troelsen Henrik Husted Kirill Gromov | 2018 | World Journal of Orthopedics2018，9，10： | 3 |
| 18 | Comparing corneal outcome between femtosecond laser-assisted cataract surgery and conventional phaco surgery in Fuchs’endothelial dystrophy patients:a randomized pilot study with 6mo follow up显示文摘AIM:To compare the corneal outcome in Fuchs’endothelial dystrophy(FED)patients between femtosecond laser-assisted cataract surgery(FLACS)and conventional phaco surgery(CPS).METHODS:This was a randomized controlled study comparing one eye surgery by FLACS and the contralateral eye operated by CPS(stop and chop technique)in FED patients.Central corneal thickness,corneal light backscatter,corneal densitometry,and central corneal endothelial cell count and hexagonality(noncontact endothelial cell microscope),and corrected distance visual acuity(CDVA)were assessed preoperatively and at day 1,40,and 180 postoperatively.RESULTS:Totally 31 patients(16 women)were included.At day 40 postoperatively,the mean endothelial cell loss(ECL)was 23.67%by FLACS and 17.30%by CPS(P=0.53).At day 180 postoperatively,ECL was 25.58%in FLACS and 21.32%in CPS(P=0.69).Densitometry data in all layers and all annuli from anterior layer to posterior layer in annuli 0-2,2-6,6-10 and 10-12,total densitometry with all layers and all annuli was performed.A significant difference was found in 6-10(posterior layer)at day 1 with-1.42 grayscale units(GSU;95%CI:-2.66 to-0.19,P=0.02).In 10-12(anterior layer,central layer and all layers)at day 40 were significant different with 7.7(95%CI:1.89 to 13.50,P=0.009),3.97(95%CI:0.23 to 7.71,P=0.03),4.73 GSU(95%CI:0.71 to 8.75,P=0.02),respectively.In the remaining parameters we found no difference between the two groups(P>0.05).Three CPS eyes suffered from corneal decompensation.CONCLUSION:There is no significant difference in corneal outcome between FLACS and CPS.Endothelial cell density and pentacam corneal outcome may be inadequate as outcome parameters in FED patients. | Therese Krarup Kathrine Rose Aurore Marie-Laurence AkpeMensah Morten la Cour Lars Morten Holm | 2021 | International Journal of Ophthalmology(English edition)2021，14，5： | 3 |
| 19 | 细胞色素c突变体F82H的表面增强拉曼和电化学研究显示文摘应用表面增强拉曼光谱和循环伏安法研究了细胞色素c及其突变体F82H的氧化还原性质 .结果表明苯丙氨酸对组氨酸的取代使得蛋白质结构更为稳定 .相对于原体蛋白质 ,突变体的氧化还原电位向负电位方向移动 ,这被归因于由氧化还原过程中伴随有配体转换反应影响所致 . | 郑军伟 顾仁敖 陆天虹 George Chumanov Therese Cotton | 2001 | 电化学2001，7，1： | 2 |
| 20 | Effect of Six-Food Elimination Diet on Clinical and Histologic Outcomes in Eosinophilic Esophagitis显示文摘 | Amir F. Kagalwalla Timothy A. Sentongo Sally Ritz Therese Hess Suzanne P. Nelson Karan M. Emerick Hector Melin–Aldana B.U.K. Li | 2006 | Clinical Gastroenterology and Hepatology2006，，： | 2 |
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