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| 1 | Minimally invasive treatment of pancreatic necrosis显示文摘AIM: To systematically review these minimally invasive approaches to infected pancreatic necrosis. METHODS: We used the MEDLINE database to investigate studies between 1996 and 2010 with greater than 10 patients that examined these techniques. Using a combination of Boolean operators, reports were retrieved addressing percutaneous therapy (341 studies), endoscopic necrosectomy (574 studies), laparoscopic necrosectomy via a transperitoneal approach (148 studies), and retroperitoneal necrosectomy (194 studies). Only cohorts with at least 10 or more patients were included. Non-English papers, letters, animal studies, duplicate series and reviews without original data were excluded, leaving a total of 27 studies for analysis. RESULTS: Twenty-seven studies with 947 patients total were examined (eight studies on percutaneous approach; ten studies on endoscopic necrosectomy; two studies on laparoscopic necrosectomy via a transperitoneal approach; five studies on retroperitoneal necrosectomy; and two studies on a combined percutaneous-retroperitoneal approach). Success rate, complications, mortality, and number of procedures were outcomes that were included in the review. We found that most published reports were retrospective in nature, and thus, susceptible to selection and publication bias. Few reports examined these techniques in a comparative, prospective manner. CONCLUSION: Each minimally invasive approach though was found to be safe and feasible in multiple reports. With these new techniques, treatment of infected pancreatic necrosis remains a challenge. We advocate a multidisciplinary approach to this complex problem with treatment individualized to each patient. | Brian Bello Jeffrey B Matthews | 2012 | World Journal of Gastroenterology2012，18，46： | 17 |
| 2 | Sedimentology and Chronology of Paleogene Coarse Clastic Rocks in East-Central Tibet and Their Relationship to Early Tectonic Uplift显示文摘系统的 sedimentological 和在东方中央的西藏的典型 Paleogenebasins 的按年代先后的学习建议 depositional 特征广泛地 床developedhuge ,在地区性的推进的一个构造背景形成的略呈紫色红的粗糙的碎屑岩并且滑倒罢工代表在泥石流和扇子表面在近似、快速积累的沉积身体形成的典型干燥、热的地面上的冲积扇环境编织的河。从盆地,硫充满序列的联合结果, seq 床widespreadmassive 的粗糙的碎屑岩,褶层在东方中央的西藏的早第三纪盆推进和走向滑倒,弄短的戳,和火的活动显示那早 diachronous 构造高举可能从对始新世的中间发生在西藏的高原渐新世,与印度、亚洲的盘子的碰撞的原始期有关。 | ZHOU Jiangyu WANG Jianghai K. H. BRIAN A. YIN M. S. MATTHEW | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 6 |
| 3 | SKOSCore:简约知识组织网络表述语言显示文摘简约知识组织表述语言(SKOS Core)以资源描述框架(RDF)为基础,是一种表述规范词表中的基本结构和概念表内容的格式语言。所谓概念表(Concept Scheme)是指某领域里所有概念及概念之间的语义关系的集合。SKOS Core由网络联盟(W3C)语义网(Semantic Web)下的最佳实践和应用工作小组(Best Practice andDeployment Working Group)出版并维护。本文的主要目的是为SKOS Core在都柏林元数据中结合使用提供一些基本的诠释。通过给出各种规范词表用SKOS Core表达的例子,该文介绍了SKOS Core的管理政策、SKOS Core与都柏林元数据、资源描述框架结构语言(RDF Schema)以及网络实用分类系统语言(Web Ontology Language,OWL)之间的关系。SKOS Core的发展仍处在初级阶段,本文的介绍希望能够起到一个抛砖引玉的作用,同时也能促进下一步的发展,与都柏林元数据词汇的使用结合起来。 | Alistair Miles Brian Matthews Michael Wilson Dan Brickley | 2006 | 现代图书情报技术2006，，1： | 5 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | Random forest machine learning models for interpretable X-ray absorption near-edge structure spectrum-property relationships显示文摘X-ray absorption spectroscopy(XAS)produces a wealth of information about the local structure of materials,but interpretation of spectra often relies on easily accessible trends and prior assumptions about the structure.Recently,researchers have demonstrated that machine learning models can automate this process to predict the coordinating environments of absorbing atoms from their XAS spectra.However,machine learning models are often difficult to interpret,making it challenging to determine when they are valid and whether they are consistent with physical theories.In this work,we present three main advances to the data-driven analysis of XAS spectra:we demonstrate the efficacy of random forests in solving two new property determination tasks(predicting Bader charge and mean nearest neighbor distance),we address how choices in data representation affect model interpretability and accuracy,and we show that multiscale featurization can elucidate the regions and trends in spectra that encode various local properties. | Steven B.Torrisi Matthew R.Carbone Brian A.Rohr Joseph H.Montoya Yang Ha Junko Yano Santosh K.Suram Linda Hung | 2020 | npj Computational Materials2020，，1： | 3 |
| 6 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 7 | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion显示文摘Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely understood.Here,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)fragments.Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses.Moreover,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model.The FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein expression.Moreover,targeting the MNK1/2 pathway diminished arthritic bone erosion.These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min | 2021 | Bone Research2021，9，4： | 2 |
| 8 | Bortezomib Provides Effective Therapy for Antibody- and Cell-Mediated Acute Rejection显示文摘 | Matthew J. Everly Jason J. Everly Brian Susskind Paul Brailey Lois J. Arend Rita R. Alloway Prabir Roy-Chaudhury Amit Govil Gautham Mogilishetty Adele H. Rike Michael Cardi George Wadih Amit Tevar E Steve Woodle | 2008 | Transplantation2008，，12： | 2 |
| 9 | Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis显示文摘 | Matthew Rutter Brian Saunders Kay Wilkinson Steve Rumbles Gillian Schofield Michael Kamm Christopher Williams Ashley Price Ian Talbot Alastair Forbes | 2004 | Gastroenterology2004，，： | 2 |
| 10 | Thirty-Year Analysis of a Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis显示文摘 | Matthew D. Rutter Brian P. Saunders Kay H. Wilkinson Steve Rumbles Gillian Schofield Michael A. Kamm Christopher B. Williams Ashley B. Price Ian C. Talbot Alastair Forbes | 2006 | Gastroenterology2006，，： | 2 |
| 11 | Acute exercise facilitates brain function and cognition in children who need it most: An ERP study of individual differences in inhibitory control capacity显示文摘 | Eric S. Drollette Mark R. Scudder Lauren B. Raine R. Davis Moore Brian J. Saliba Matthew B. Pontifex Charles H. Hillman | 2014 | Developmental Cognitive Neuroscience2014，，： | 1 |
| 12 | Paracrine activation of hepatic stellate cells in platelet‐derived growth factor C transgenic mice: Evidence for stromal induction of hepatocellular carcinoma显示文摘 | Jocelyn H. Wright Melissa M. Johnson Masami Shimizu‐Albergine Renay L. Bauer Brian J. Hayes James Surapisitchat Kelly L. Hudkins Kimberly J. Riehle Simon C. Johnson Matthew M. Yeh Theodor K. Bammler Richard P. Beyer Debra G. Gilbertson Charles E. Alpers N | 2014 | Int. J. Cancer2014，，4： | 1 |
| 13 | Exercise Improves Behavioral, Neurocognitive, and Scholastic Performance in Children with Attention-Deficit/Hyperactivity Disorder显示文摘 | Matthew B. Pontifex Brian J. Saliba Lauren B. Raine Daniel L. Picchietti Charles H. Hillman | 2012 | The Journal of Pediatrics2012，，： | 1 |
| 14 | Matrix and fiber influences on the cryogenic microcracking of carbon fiber/epoxy composites显示文摘 | John F Timmerman Matthew S Tillman Brian S Hayes et at | 2002 | Composites2002，33，： | 1 |
| 15 | Seedling establishment shapes the distribution of shade-adapted forest herbs across a topo- graphical moisture gradient显示文摘 | Matthew A Brian C | 2009 | Journal of Ecology2009，97，5： | 1 |
| 16 | Most dysplasia in ulcerative colitis is visible at colonoscopy显示文摘 | Matthew D. Rutter Brian P. Saunders Kay H. Wilkinson Michael A. Kamm Christopher B. Williams Alastair Forbes | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 17 | Molecular mechanism of cAMP modulation of HCN pacemaker channels 显示文摘 | Brian J Matthew D Bina S | 2001 | Nature2001，411，6839： | 1 |
| 18 | Morphological and meehanical properties of eaudal vertebrae in the SAMP6 mouse model of senile osteoporosis 显示文摘 | MATTHEW J S MICHAEL D B BRIAN A | 2004 | Bone2004，35，7： | 1 |
| 19 | Percutaneous Fixation of Proximal Humerus Fractures显示文摘 | Brian Magovern Matthew L. Ramsey | 2008 | Orthopedic Clinics of North America2008，，4： | 1 |
| 20 | Vasospasm After Aneurysmal Subarachnoid Hemorrhage: Review of Randomized Controlled Trials and Meta-Analyses in the Literature显示文摘 | Gregory J. Velat Matthew M. Kimball J.D. Mocco Brian L. Hoh | 2011 | World Neurosurgery2011，，： | 1 |
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