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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | Bouchier-Hayes,Taurine attenuates LPS-induced and rolling and adhesion in rat microcirculation显示文摘 | Bridget M Egan Gang Chen Cathal J | 2001 | Journal of Surgical Research2001，95，： | 1 |
| 3 | Kinases SPAK and OSRI are up regulated by estradiol and activate NKCC1 in the developing hypothalamus 显示文摘 | Bridget M Nugent Carla V Valenzuela Timothy J Simons | 2012 | J Neurosci2012，32，2： | 1 |
| 4 | Impact of Donor Age and Year of Transplantation on Graft and Patient Survival Following Liver Transplantation for Hepatitis C Virus显示文摘 | David J. Mutimer Bridget Gunson John Chen J Berenguer Peter Neuhaus D Castaing J C. Garcia-Valdecasas M Salizzoni Gonzalez E. Moreno Darius Mirza | 2006 | Transplantation2006，，1： | 1 |
| 5 | The conditional probability of survival of patients with primary malignant brain tumors:surveillance, epidemiolgy, and end results(SEER) data显示文摘 | Faith G D Bridget J M Sally F | 1999 | Cancer1999，85，2： | 1 |
| 6 | Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa显示文摘Multiple endocrine neoplasia 2B(MEN2B) is a rare syndrome caused by an activating mutation of the RET gene, leading to enteric gangliomatosis. This child presented with constipation at 1-mo old, was diagnosed with MEN2 B by rectal biopsy at 4 mo, had thyroidectomy at 9 mo and a colectomy at 4 years. We studied the extent of neuronal and nerve fibre proliferation and which classes of enteric nerves are affected by examining the colon with multiple neuronal antibodies. Resected transverse colon was fixed, frozen, sectioned and processed for fluorescence immunohistochemistry labelling with antibodies against TUJ1, Hu, ChAT, NOS, VIP, SP and CGRP and cKit. Control transverse colon was from the normal margin of Hirschsprung(HSCR) colon(4-year-old) and a child with familial adenomatous polyposis(FAP, 12 year). Myenteric ganglia were increased in size to as wide as the circular muscle. There was a large increase in nerve cells and nerve fibres. ChAT-, NOS-, VIP-and SP-immunoreactive nerve fibres all increased in the myenteric ganglia. NOS-IR nerves preferentially increased in the muscle, while VIP and SP increased in submucosal ganglia and mucosal nerve fibres. The density of ICC was normal. RET overactivation in MEN2B lead to a large increase in intrinsic nerve fibres in the myenteric and submucosal ganglia, with a relative increase in NOS-IR nerve fibres in the circular muscle and VIP and SP in the submucosal ganglia and mucosa. The changes were associated with severe constipation resulting in colectomy at 4 years. | John M Hutson Pam J Farmer Cristal J Peck Chung W Chow Bridget R Southwell | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 1 |
| 7 | Can fabric sensors monitor breast motion? 显示文摘 | CAMPBELL T E BRIDGET J M | 2007 | Journal of Biomechanics2007，40，： | 1 |
| 8 | Leader - Member Exchange and Organization- al Communication Satisfaction in Multiple Contexts 显示文摘 | BRIDGET H M LEE J | 2002 | The Journal of Business Communication2002，2，39： | 1 |
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