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| 1 | Second-line treatments for advanced gastric cancer: Interpreting outcomes by network meta-analysis显示文摘AIM: To study the effectiveness of second-linetreatments for advancer gastric cancer by application of Bayesian network meta-analysis.METHODS: Our search covered the literature up to February 2015. The following 6 treatments were evaluated:(1) irinotecan(camptothecins);(2) paclitaxel(taxanes class);(3) docetaxel(taxanes);(4) everolimus(mammalian target of rapamycin inhibitors);(5) ramucirumab(vascular endothelial growth factor receptor 2 inhibitors);(6) ramucirumab + paclitaxel. Our methodology was based on standard models of Bayesian network meta-analysis. The reference treatment was best supportive care(BSC). The endpoint was overall survival. Median survival was the outcome measure along with 95% credible intervals. RESULTS: Our search identified a total of 7 randomized controlled trials. These trials included 2298 patients(in 15 treatment arms) in whom a total of 6 active treatments were evaluated as well as BSC. There were 21 head-to-head comparisons(6 direct, 15 indirect). The difference in survival between each of two active treatments(paclitaxel and ramucirumab + paclitaxel) vs BSC was statistically significant, while the other 4 showed no statistical difference. In the 6 head-to-head comparisons between active treatments, no significant survival difference was demonstrated. CONCLUSION: Our results indicate that both paclitaxel monotherapy and ramucirumab + paclitaxel determine a significant prolongation in survival as compared with BSC. | Brigitta Badiani Dario Maratea Andrea Messori | 2015 | World Journal of Clinical Oncology2015，6，4： | 6 |
| 2 | 青藏高原纳木错湖阶沉积的发生特征及环境指示意义显示文摘选取的21个湖相沉积物样品分别采自纳木错湖西岸塔吉古日(剖面NamCo1)和纳木错湖东北岸的干玛弄附近(剖面NamCo2)。按照其发生特征分别将剖面从顶部到底部划分为12个和9个层次,通过分析各个层次沉积物的粒径分布特征、质地组成特点、总有机碳(TOC)、总无机碳(TIC)、总碳(TC)的百分含量、酸度值(pH)、电导率(EC)、含水量等若干环境指示因子。结果显示:无论在比较两个剖面的发生特征,还是环境指示因子特征,剖面NamCo1发育程度较剖面NamCo2更加发育;通过对测年数据结果分析,两个剖面均形成于晚更新世,并且通过比较各自剖面在垂直方向上的各项环境指示因子的变化趋势,可知纳木错湖流域在晚更新世(约40kaBP)阶段发生过3次相对明显的冷暖交替过程. | 王利强 易朝路 Brigitta Schutt 董国成 | 2009 | 沉积学报2009，27，3： | 5 |
| 3 | Different cava reconstruction techniques in liver transplantation:piggyback versus cava resection显示文摘BACKGROUND: Originally, cava reconstruction(CR) in liver transplantation meant complete resection and reinsertion of the donor cava. Alternatively, preservation of the recipients inferior vena cava(IVC) with side-to-side anastomosis(known as 'piggyback') can be performed. Here, partial clamping maintains blood flow of the IVC, which may improve cardiovascular stability, reduce blood loss and stabilize kidney function. The aim of this study was to compare both techniques with particular focus on kidney function.METHODS: A series of 414 patients who had had adult liver transplantations(2006-2009) were included. Among them,176(42.5%) patients had piggyback and 238 had classical CR operation, 112(27.1%) of the patients underwent CR accompanied with veno-venous bypass(CR-B) and 126(30.4%)without a bypass. The choice of either technique was based on the surgeons' individual preference. Kidney function [serum creatinine, calculated glomerular filtration rate(GFR), RIFLE stages] was assessed over 14 days.RESULTS: Lab-MELD scores were significantly higher in CR-B(22.5±11.0) than in CR(17.3±9.0) and piggyback(18.8±10.0)(P=0.008). Unexpectedly, the incidences of arterial stenoses(P=0.045) and biliary leaks(P=0.042) were significantly increased in piggyback. Preoperative serum creatinine levels were the highest in CR-B [1.45±1.17 vs 1.25±0.85(piggyback)and 1.13±0.60 mg/dL(CR); P=0.033]. Although a worsening of postoperative kidney function was observed among all groups,this was most pronounced in CR-B [creatinine day 14: 1.67±1.40 vs 1.35±0.96(piggyback) and 1.45±1.03 mg/dL(CR); P=0.102].Accordingly, the proportion of patients displaying RIFLE stages≥2 was the highest in CR/CR-B(26%/19%) when compared to piggyback(18%).CONCLUSIONS: Piggyback revealed a shorter warm ischemic time, a reduced blood loss, and a decreased risk of acute kidney failure. Thus, piggyback is a useful technique, which should be applied in standard procedures. When piggyback is unfeasible,cava replacement, which displayed a lower incidence of vascular and biliary complications in our study, remains as a safe alternative. | Volker Schmitz Wenzel Schoening Ines Jelkmann Brigitta Globke Andreas Pascher Marcus Bahra Peter Neuhaus Gero Puhl | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 5 |
| 4 | Phytochemical overview and medicinal importance of Coffea species from the past until now显示文摘Coffea(coffee) species are grown in almost all countries along the Equator. Many members of the genus have a large production history and an important role both in the global market and researches. Seeds(Coffeae semen) are successfully used in food, cosmetic, and pharmaceutical industries due to its caffeine and high polyphenol content. Nowadays, the three best-known coffee species are Arabic(Coffea arabica L.), Robusta(Coffea robusta L. Linden), and Liberian coffees(Coffea liberica Hier.). Even though, many records are available on coffee in scientific literature, wild coffee species like Bengal coffee(Coffea benghalensis Roxb. Ex Schult.) could offer many new opportunities and challenges for phytochemical and medical studies. In this comprehensive summary, we focused on the ethnomedicinal, phytochemical, and medical significance of coffee species up to the present. | éva Brigitta Patay Tímea Bencsik Nóra Papp | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 4 |
| 5 | Antioxidant potential,tannin and polyphenol contents of seed and pericarp of three Coffea species显示文摘Objective:To investigate the antioxidant activity,total phenolic and total tannin content of the pericarp and the seed of Coffea benghalensis(C.benghalensis) and Coffea liberica compared to Coffea arabica(C.arabica).Methods:The antioxidant potential,total tannin and polyphenol contents of the immature and mature seed and pericarp of C.benghalensis and Coffea liberica were quantified and compared to C.arabica.Enhanced chemiluminescence(ECL).2,2-diphenyl-1-picrylhydruzyl(DPPH).oxygen radical absorbance capacity,Folin-Ciocaltcau method and total tannin content assays were used.Results:Trolox equivalent(TE/g plant material) values obtained by ECL and DPPH methods showed loose correlation(r^2=0.587)while those measured by oxygen radical absorbance capacity assay were higher without correlation in each plant.A closer correlation was detected between the ECL method and the percentage antioxidant activity of the DPPH technique(r^2=0.610 7) in each species,however the immature pericarp of C.benghalensis showed much higher DPPH scavenging potential than was seen in the ECL assay.The immature pericarp of C.benghalensis expressed the highest tannin and polyphenol content,and a high polyphenol level was also detected in the immature seed of C.arabica.The immature pericarp of Bengal and Liberian coffees showed the largest amount of phenolic contents.Conclusions:The obtained data highlight the potential role of C.benghalensis as a new source of natural antioxidants and polyphenols compared to C.arabica. | va Brigitta Patay Nikolett Sali Tams Kszegi Rita Csepregi Viktória Lilla Blaz Tibor Sebastian Németh Tibor Németh Nóra Papp | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 3 |
| 6 | Soil Properties in Two Soil Profiles from Terraces of the Nam Co Lake in Tibet,China显示文摘This article investigates the soil properties in two soil profiles from the terraces of the Nam Co Lake in Tibet,China. Profile 1,with a slope aspect to east,is 37 m,and profile 2,to southwest,is 32 m above the lake level. Twelve and nine layers were identified in profile 1 and profile 2,respectively,based on the color,texture,structure,moisture content,presence of carbonate,and root density. Grain sizes and measurements of water content,total organic carbon,total inorganic carbon,total carbon,pH value and electrical conductivity were all analyzed for each sample. The results show that soil is poorly developed because of sparse vegetation coverage and weak chemical weathering in the cold and arid area. The results also indicate that the soil properties are different between the two profiles and suggest that soil is better developed in profile 1 than in profile 2. These differences are ascribed to the dissimilarity of landform,vegetation and timing. Profile 1 faces to east as compared with profile 2 facing to southwest and gets less insolation and therefore less evaporation. Thus,vegetation grows better in profile 1 than in profile 2. Radiocarbon dating and OSL dating show that profile 1 underwent a longer soil forming process than profile 2,which is helpful for the soil development in profile 1. | WANG Liqiang YI Chaolu Brigitta Sehiitt LIU Kexin ZHOU Liping | 2009 | Journal of Mountain Science2009，6，4： | 2 |
| 7 | Prophylactic transcatheter arterial embolization reduces rebleeding in non-variceal upper gastrointestinal bleeding: A meta-analysis显示文摘BACKGROUND Despite the improvement in the endoscopic hemostasis of non-variceal upper gastrointestinal bleeding(NVUGIB),rebleeding remains a major concern.AIM To assess the role of prophylactic transcatheter arterial embolization(PTAE)added to successful hemostatic treatment among NVUGIB patients.METHODS We searched three databases from inception through October 19th,2020.Randomized controlled trials(RCTs)and observational cohort studies were eligible.Studies compared patients with NVUGIB receiving PTAE to those who did not get PTAE.Investigated outcomes were rebleeding,mortality,reintervention,need for surgery and transfusion,length of hospital(LOH),and intensive care unit(ICU)stay.In the quantitative synthesis,odds ratios(ORs)and weighted mean differences(WMDs)were calculated with the random-effects model and interpreted with 95%confidence intervals(CIs).RESULTS We included a total of 3 RCTs and 9 observational studies with a total of 1329 patients,with 486 in the intervention group.PTAE was associated with lower odds of rebleeding(OR=0.48,95%CI:0.29–0.78).There was no difference in the 30-d mortality rates(OR=0.82,95%CI:0.39–1.72)between the PTAE and control groups.Patients who underwent PTAE treatment had a lower chance for reintervention(OR=0.48,95%CI:0.31–0.76)or rescue surgery(OR=0.35,95%CI:0.14–0.92).The LOH and ICU stay was shorter in the PTAE group,but the difference was non-significant[WMD=-3.77,95%CI:(-8.00)–0.45;WMD=-1.33,95%CI:(-2.84)–0.18,respectively].CONCLUSION PTAE is associated with lower odds of rebleeding and any reintervention in NVUGIB.However,further RCTs are needed to have a higher level of evidence. | Eszter Boros Zoltán Sipos Péter Hegyi Brigitta Teutsch Levente Frim Szilárd Váncsa Szabolcs Kiss FanniDembrovszky Eduard Oštarijaš Andrew Shawyer Bálint Erőss | 2021 | World Journal of Gastroenterology2021，27，40： | 2 |
| 8 | Differentiation and function of Th17 T cells显示文摘 | Brigitta Stockinger Marc Veldhoen | 2007 | Current Opinion in Immunology2007，，3： | 2 |
| 9 | Noncompliance in organ transplant recipients: a literature review显示文摘 | Kurt LH Brigitta B | 2000 | General Hospital Psychiatry2000，22，： | 1 |
| 10 | An Update on Immunodiagnosis of Cystic Echinococcosis显示文摘 | Elena Ortona Rachele Rigano Brigitta Buttari | 2003 | Acta Tropica2003，85，： | 1 |
| 11 | Combining algorithms for automatic detection of optic disc and macula in fundus images显示文摘 | Rashid Jalal Qureshi Laszlo Kovacs Balazs Harangi Brigitta Nagy Tunde Peto Andras Hajdu | 2011 | Computer Vision and Image Understanding2011，，1： | 1 |
| 12 | Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats显示文摘 | Andreas Kleine MD Stefan Kluge Prof. Dr. Brigitta M. Peskar MD | 1993 | Digestive Diseases and Sciences1993，，8： | 1 |
| 13 | Heavy metal accumulation and tolerance of energy grass ( Elymus elongatus subsp. ponticus cv. Szarvasi-1) grown in hydroponic culture显示文摘 | Gyula Sipos ádám Solti Viktória Czech Ildikó Vashegyi Brigitta Tóth Edit Cseh Ferenc Fodor | 2013 | Plant Physiology and Biochemistry2013，，： | 1 |
| 14 | Selective cyclo‐oxygenase‐2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach显示文摘 | BrittaGretzer KarlheinzEhrlich NenadMaricic NilsLambrecht MichaelRespondek Brigitta M.Peskar | 2009 | British Journal of Pharmacology2009，，5： | 1 |
| 15 | Clinical device‐related article surface characterization of explanted endovascular stents: Evidence of in vivo corrosion显示文摘 | Dina O.Halwani Peter G.Anderson Brigitta C.Brott Andreas S.Anayiotos Jack E.Lemons | 2010 | J Biomed Mater Res2010，，1： | 1 |
| 16 | Parental information, motivation, and adherence behaviors among children with sickle cell disease显示文摘 | Jean L. Raphael Ashley M. Butler Tiffany L. Rattler Marc A. Kowalkowski Brigitta U. Mueller Thomas P. Giordano | 2013 | Blood Cancer2013，，7： | 1 |
| 17 | Interferon gamma boosts the nucleotide oligomerization domain 2-mediated signaling pathway in human dendritic cells in an X-linked inhibitor of apoptosis protein and mammalian target of rapamycin-dependent manner显示文摘细胞质的核苷酸 oligomerization 领域 2 (NOD2 ) 受体认出细菌的房间墙部件 muramyl dipeptide (MDP ) 。NOD2 结扎开始原子因素 kappa B 和激活 mitogen 的蛋白质 kinase 串联。然而,独自管理 MDP 是不够的在各种各样的有免疫力的房间得到强壮的 cytokine 回答,包括树枝状的房间(DC ) 。因为在煽动的纸巾的各种各样的微生物引起的产品和 cytokines 的同时的存在调制 DC 功能,我们开始了这研究检验怎么干扰素 gamma (IFN ) ,发炎的一个中央调节的人,在人的常规 DC (cDCs ) 影响调停 NOD2 的发信号小径。有 MDP 和 IFN 的 DC 的 Synergistic 刺激增加了 CD40, CD80, CD83, CD86,和人的白血球抗原 DQ 的表示蛋白质并且显著地提高了支持 inflammatory cytokines IL-1, IL-6, IL-12,和瘤坏死的生产因素(TNF ) ,以及反煽动性的 cytokine IL-10。而且, MDP 和 IFN 的同时的存在对减少 IkB 蛋白质层次必要。由调查,各种各样的机制在调停 MDP 、调停 IFN 的发信号的小径含有,我们表明支持 inflammatory cytokines 的增加的生产高度依赖于 apoptosis 蛋白质(XIAP ) 的 X 连接禁止者然而并非在细胞的 IAP1 和 IAP2 上。我们也发现表明小径的 NOD2 被 rapamycin (mTOR ) 的哺乳动物的目标调整,但是没被 phosphatidylinositol-3 kinase 或信号变换器和抄写 1 抑制的使活跃之物影响。第一次,我们的结果证明 IFN 断然影响在人的 cDCs 的调停 NOD2 的发信号,以更加依赖于 XIAP 并且部分的一种方式依赖于 mTOR。 | Tunde Fekete Gabor Koncz Brigitta Szabo Andrea Gregus Eva Rajnavolgyi | 2017 | Cellular & Molecular Immunology2017，14，4： | 1 |
| 18 | Wnt3a deficiency irreversibly impairs hematopoietie stem cell self-renewal andleads to defects in progenitor cell differentiation 显示文摘 | Tiago CL Floor W Brigitta A | 2009 | Blood2009，113，3： | 1 |
| 19 | Radiation treatment planning with an integrated position emission and computer tomography (PET/CT):a feasibility study显示文摘 | Frank Ciernik Elena Dizendorf Brigitta G | 2003 | Int J Radiat Phys2003，51，3： | 1 |
| 20 | Variation in endogenous cytokinin contentduring adventitious root formation in Pea cuttings显示文摘 | BOLLMARK M BRIGITTA K LENNART E | 1988 | J Plant Physiol1988，132，： | 1 |
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