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19篇 您的检索式：作者名="Bronner A"

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		题名	作者	年代	出处	被引量
	1	Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer显示文摘AIM:To characterize tumor necrosis factor receptorassociated protein 1(TRAP1)expression in the progression of ulcerative colitis(UC)-associated colorectal cancer.METHODS:Chronic UC is an inflammatory bowel disease that predisposes to colorectal cancer.Immunohistochemical analysis was used to evaluate TRAP1expression on tissue microarrays containing colonic tissues from 42 UC progressors(patients with cancer or dysplasia)and 38 non-progressors(dysplasia/cancer free patients).Statistical analyses of the TRAP1immunohistochemistry staining were performed using Graph Pad Prism.Differences in the TRAP1 level between non-progressors and progressors were tested for statistical significance using the Mann-Whitney test.Receiver operating characteristic curve method was used to quantify marker performance in distinguishing diseased cases from controls.RESULTS:TRAP1 was up-regulated in the colon tissues from UC progressors,but not in the colon tissues from UC non-progressors.Moreover,up-regulation of TRAP1 preceded the neoplastic changes:it was present in both the dysplastic and non-dysplastic tissues of UC progressors.When TRAP1 staining in rectal tissue was used as a diagnostic marker,it could distinguish progressors from non-progressors with 59%sensitivity and 80%specificity.Our study further showed that the increase of TRAP1 expression positively correlated with the degree of inflammation in the colorectal cancer tissues,which could be related to the increased oxidation present in the colonic mucosa from UC progressors.We then investigated the cellular proteome changes underlying oxidative stress,and found that oxidative stress could induce up-regulation of TRAP1 along with several other negative modulators of apoptosis.CONCLUSION:These results suggest that oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1,which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer.	Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall	2014	World Journal of Gastroenterology2014，20，45：	9
	2	Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants显示文摘	Hinney A Nguyen T T Scherag A Friedel S Bronner G Muller T D Grallert H Illig T Wichmann H E Rief W Schafer H and Hebebrand J		0，，12：	1
	3	Ambipolar charge carrier transport in mixed organic layers of phthalocyanine and fullerene显示文摘	OPITZ A BRONNER M BRUTTlNG W	2007	J Appl Phys2007，101，06：	1
	4	Parietal and temporal activity during a multimodal dance video game:An fNIRS study显示文摘	TACHIBANA A NOAH J A BRONNER S		0，，02：	1
	5	Sipl mediates an E-cadherin- to-N-cadherin switch during cranial neural crest EMT 显示文摘	Rogers CD Saxena A Bronner ME	2013	J Cell Bid2013，203，5：	1
	6	Chromosomal instability in ulcerative colitis is related to telomere shortening 显示文摘	O' Sullivan J N Bronner M P Brentnall T A	2002	Nat Genet2002，32，2：	1
	7	Comparative abilities of Microsoft Kinect and Vicon 3D motion capture for gait analysis 显示文摘	Pfister A West A M Bronner S	2014	Journal of Medical Engineering & Technology2014，38，5：	1
	8	Magmatic break- up as an explanation for magnetic anomalies at magma poor rifted margins显示文摘	Bronner A Sauter D Manatschal G	2011	Nature Geoscience2011，4，8：	1
	9	Swedish traveller with Plasmodium knowlesi malaria after visiting Malaysian Borneo显示文摘	Bronner U Divis PC Farnert A	2009	Malar J2009，8，：	1
	10	Activation of dorsolat- eral prefrontal cortex in a dual neuropsychological screening test: An fMRI approach显示文摘	Tachibana A Noah JA Bronner S	2012	Behav Brain Funct2012，8，：	1
	11	Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: an fM- RI approach 显示文摘	Tachibana A Noah JA Bronner S	2012	Behav Brain Funct2012，28，：	1
	12	Challenges and future direction for the scaling of Dynamic random-access memory (DRAM)显示文摘	MANDELELMAN J A DENNARD R H BRONNER G B	2002	IBM J Res Dev2002，46，23：	1
	13	Magmatic break- up as an explanation for magnetic anomalies at magma-poor rifted margins显示文摘	Bronner A Sauter D Manatschal G	2011	Nature Geoscienee2011，4，8：	1
	14	Highly recommended: The content characteristics and per- ceived usefulness of online consumer reviews显示文摘	Willemsen L M Neijens P C Bronner F and De Ridder J A	2011	Journal of Computer Mediated Communication2011，17，1：	1
	15	Postmenopausal estrogen therapy selectively stimulates hepatic enlargement in women with autosomal dominant polycystic kidney disease.显示文摘	R Sherstha C McKinley P Russ A Scherzinger T Bronner R Showalter GT Everson	1997	Hepatology1997，，5：	1
	16	TCR pathway involves ICBP90 gene down-regulation via E2F binding sites显示文摘	ABBADY A BRONNER C BATHAMI K	2005	Biochem Pharmacol2005，70，4：	1
	17	A pilot study on peritraumatic dissociation and coping styles as risk factors for posttraumatic stress, anxiety and depression in t parents after their child s unexpected admission to a Pediat ric Intensive Care Unit显示文摘	Bronner M B Kayser A M Knoester H	2009	Child Adolesc Psychiatry Ment Heahh2009，3，1：	1
	18	Activation of platelet transforming growth factor -1 in the absence of thrombospondin-1显示文摘	Abdelouahed M Ludlow A Bronner G	2000	J Biol Chem2000，275，17：	1
	19	Predietion of ovarian hyperstimulation syndrome of baseline ovarian volume Prior tostimulation显示文摘	Danninger B Bronner M Obruea A	1996	Hum Reprod1996，11，：	1

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