|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | 受虐妇女综合症专家证据在澳大利亚司法实践中的运用显示文摘在涉及家庭暴力的刑事案件中,如何处理以暴制暴杀夫的女性,保证她们获得公正的处遇,是法官面临的难题,受虐妇女综合症专家证据的运用,为破解此难题,提供了一种有效途径。本文立足澳大利亚若干个案,分析了受虐妇女综合症的含义及其在刑事审判中的运用原则、类型与效果,并阐述了受虐妇女综合症专家证据对刑事审判带来的挑战。这对于中国司法官员在刑事审判中如何导入受虐妇女综合症专家证据,具有很强的借鉴意义。 | Bronwyn Barta 黄晓文 叶衍艳 | 2005 | 法学杂志2005，26，6： | 6 |
| 3 | MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice显示文摘 | Callis Thomas E Pandya Kumar Seok Hee Young Tang Ru-Hang Tatsuguchi Mariko Huang Zhan-Peng Chen Jian-Fu Deng Zhongliang Gunn Bronwyn Shumate Janelle Willis Monte S Selzman Craig H Wang Da-Zhi | 2009 | Journal of Clinical Investigation2009，，9： | 3 |
| 4 | Comparative effectiveness of Biobrane^(■),RECELL^(■)Autologous skin Cell suspension and Silver dressings in partial thickness paediatric burns:BRACS randomised trial protocol显示文摘Background:Mixed partial thickness burns are the most common depth of burn injury managed at a large Australian paediatric hospital specialty burns unit.Prolonged time until re-epithelialisation is associated with increased burn depth and scar formation.Whilst current wound management approaches have benefits such as anti-microbial cover,these are not without inherent limitations including multiple dressing changes.The Biobrane^(■)RECELL^(■)Autologous skin Cell suspension and Silver dressings(BRACS)trial aims to identify the most effective wound management approach for mixed partial thickness injuries in children.Methods:All children presenting with an acute burn injury to the study site will be screened for eligibility.This is a single-centre,three-arm,parallel group,randomised trial.Children younger than 16 years,with burns≥5%total body surface area involving any anatomical location,up to 48 h after the burn injury,and of a superficial partial to mid-dermal depth,will be included.A sample size of 84 participants will be randomised to standard silver dressing or a Regenerative Epithelial Suspension(RES^(TM))with Biobrane^(■)or Biobrane^(■)alone.The first dressing will be applied under general anaesthesia and subsequent dressings will be changed every 3 to 5 days until the wound is≥95%re-epithelialised,with re-epithelialisation time the primary outcome.Secondary outcomes of acute pain,acute itch,scar severity,health-related quality of life,treatment satisfaction,dressing application ease and healthcare resource use will be assessed at each dressing change and 3,6 and 12 months post-burn injury.Discussion:The findings of this study can potentially change the wound management approach for superficial partial to mid-dermal burns in children locally and worldwide.Trial registration:The Australian New Zealand Clinical Trials Registry(ACTRN12618000245291)approved prospective registration on 15 February 2018.Registration details can be viewed at http://gffzzf8a84f62798d4facs666uofk6wc0q6kpc.ffgz.tsg.suse.edu.cn/Trial/Registration/TrialReview.aspx?id=374272&isReview=true. | Anjana Bairagi Bronwyn Griffin Zephanie Tyack Dimitrios Vagenas Steven M.McPhail Roy Kimble | 2019 | Burns & Trauma2019，7，1： | 3 |
| 5 | Pregnancy and neonatal outcomes in Indigenous Australians with diabetes in pregnancy显示文摘AIM: To perform a systematic review of reported neonatal and pregnancy outcomes of Indigenous Australians with diabetes in pregnancy(DIP).METHODS: Electronic searches of Pub Med and Web of Science were carried out. Articles were selected if they contained original data on DIP outcomes in Indigenous Australians. There were no specific exclusion criteria.RESULTS: A total of eight articles, predominantly from Queensland and Western Australia were identified once inclusion criteria were applied. Birth data from midwifery registries or paper charts encompassing years 1985-2008 were used. A total of 465591 pregnant women with and without DIP were included in the eight studies, with 1363 being Indigenous women with DIP. Indigenous Australians experienced increased rates of many known adverse outcomes of DIP including: macrosomia, caesarean section, congenital deformities, low birth weight, hypoglycaemia, and neonatal trauma. There were regional differences among Indigenous Australians, particularly regional/remote vs metropolitan populations where the regional/remote data showed worse outcomes. Two of the articles did not note a difference between Aboriginals and Caucasians in the rates of measured adverse outcome. Studies varied significantly in size, measured outcomes, and subsequent analysis.CONCLUSION: The health disparities between Indigenous Australians and non-Indigenous Australians are further evidenced by poorer outcomes in DIP. This has broader implications for Indigenous health in general. | Victor Duong Bronwyn Davis Henrik Falhammar | 2015 | World Journal of Diabetes2015，6，6： | 2 |
| 6 | Enhancement of Hematopoietic Stem Cell Repopulating Capacity and Self-Renewal in the Absence of the Transcription Factor C/EBPα显示文摘 | Pu Zhang Junko Iwasaki-Arai Hiromi Iwasaki Maris L. Fenyus Tajhal Dayaram Bronwyn M. Owens Hirokazu Shigematsu Elena Levantini Claudia S. Huettner Julie A. Lekstrom-Himes Koichi Akashi Daniel G. Tenen | 2004 | Immunity2004，，6： | 2 |
| 7 | Assessment of transgenic maize events produced by particle bombardment or Agrobacterium -mediated transformation显示文摘 | Huixia Shou Bronwyn R. Frame Steven A. Whitham Kan Wang | 2004 | Molecular Breeding2004，，2： | 2 |
| 8 | How effective are fiscal incentives for R&D? A review of the evidence显示文摘 | Bronwyn Hall John Van Reenen | 2000 | Research Policy2000，，4： | 2 |
| 9 | Does the autonomic nervous system contribute to the initiation and progression of prostate cancer?显示文摘 | Sabatino Ventura Bronwyn A Evans | 2013 | Asian Journal of Andrology2013，15，6： | 2 |
| 10 | Exploring the relationship between R&D; and productivity in French manufacturing firms显示文摘 | Bronwyn H. Hall Jacques Mairesse | 1995 | Journal of Econometrics1995，，1： | 2 |
| 11 | Tailoring specific properties of polymer-based composites by using graphene and its associated compounds显示文摘Graphene and its associated compounds have been identified as extraordinary structural nano-fillers that can tailor the properties of new polymer-based composites with specific functionalities.Graphene possesses perfect 2D atomic architecture and has a large surface area that enhances the bonding,with tailored functional groups on its surface with polymer chains to form high strength composites.Recently,a lot of research has focused on developing composites with high specific strength,high electrical and thermal conductivities,high impact resistance,excellent energy storage capability and ability to maintain their strength at low-temperature environments by using graphene,graphene oxide(GO),reduced graphene oxide(rGO)or carbon nanotube/graphene.Ultimate goals are to design composites that can meet specific requirements for different engineering applications.In this paper,the discussion on all aspects in relation to the use of graphene and its associated compounds for advanced composites will be given in detail.The potentiality of using these materials for high-tech applications will be explored.Up to date,it has been proved that the use of graphene-based nanofillers does improve the mechanical,interfacial bonding,electrical,thermal and electromagnetic interference shield properties of polymer-based materials.Appropriately adding a small amount of these nanofillers do make a big difference to the properties of host materials. | Pui-yan Hung Kin Tak Lau Qiaoshi Guo Baohua Jia Bronwyn Fox | 2020 | International Journal of Smart and Nano Materials2020，11，2： | 2 |
| 12 | SREBP transcription factors: master regulators of lipid homeostasis显示文摘 | Delphine Eberlé Bronwyn Hegarty Pascale Bossard Pascal Ferré Fabienne Foufelle | 2004 | Biochimie2004，，11： | 2 |
| 13 | Large artery stiffness predicts ischemic threshold in patients with coronary artery disease显示文摘 | Bronwyn A Kingwell Tamara K Waddell Tanya L Medley James D Cameron Anthony M Dart | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 14 | Is public R&D a complement or substitute for private R&D? A review of the econometric evidence显示文摘 | Paul A. David Bronwyn H. Hall Andrew A. Toole | 2000 | Research Policy2000，，4： | 2 |
| 15 | Trends in adolescentalcohol and other drug use:findings from three sen- tinel sites in South Africa( 1997-2001 )显示文摘 | Charles D H P Bronwyn M Neo K M | 2004 | J A dolesc2004，27，4： | 1 |
| 16 | Interactive effects of temperature and salinity on otolithchemistry:challenges for determining environmental histories of fish显示文摘 | Elsdon Travis S Gillanders Bronwyn M | 2002 | Canadian Journal of Fish-eries and Aquatic Sciences2002，59，： | 1 |
| 17 | DNA barcoding Australia's fish species显示文摘 | Robert D W Tyler S Z Bronwyn H I | 2005 | Philosophical Transactions of the Royal Socity B2005，360，1462： | 1 |
| 18 | The Financing of Research and Development 显示文摘 | Hall Bronwyn H | 2002 | Oxford Review of Economic Policy2002，18，1： | 1 |
| 19 | Risk factor for antenatal depression,Postnatal depression and Parenting stress显示文摘 | Bronwyn Leigh Jeamiette Milgrom | | 0，，： | 1 |
| 20 | How effective are fiscal incentives for R&D? A new review of the evidence 显示文摘 | Hall Bronwyn H John Van Reenen | 1996 | Research Policy1996，9，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员