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| 1 | Effect of thrombectomy on oedema progression and clinical outcome in patients with a poor collateral profile显示文摘Background and purpose The impact of the cerebral collateral circulation on lesion progression and clinical outcome in ischaemic stroke is well established.Moreover,collateral status modifies the effect of endovascular treatment and was therefore used to select patients for therapy in prior trials.The purpose of this study was to quantify the effect of vessel recanalisation on lesion pathophysiology and clinical outcome in patients with a poor collateral profile.Materials and methods 129 patients who had an ischaemic stroke with large vessel occlusion in the anterior circulation and a collateral score(CS)of 0-2 were included.Collateral profile was defined using an established 5-point scoring system in CT angiography.Lesion progression was determined using quantitative lesion water uptake measurements on admission and follow-up CT(FCT),and clinical outcome was assessed using modified Rankin Scale(mRS)scores after 90 days.Results Oedema formation in FCT was significantly lower in patients with vessel recanalisation compared with patients with persistent vessel occlusion(mean 19.5%,95%CI:17%to 22%vs mean 27%,95%CI:25%to 29%;p<0.0001).In a multivariable linear regression analysis,vessel recanalisation was significantly associated with oedema formation in FCT(ß=−7.31,SD=0.015,p<0.0001),adjusted for CS,age and Alberta Stroke Program Early CT Score(ASPECTS).Functional outcome was significantly better in patients following successful recanalisation(mRS at day 90:4.5,IQR:2-6 vs 5,IQR:5-6,p<0.001).Conclusion Although poor collaterals are known to be associated with poor outcome,endovascular recanalisation was still associated with significant oedema reduction and comparably better outcome in this patient group.Patients with poor collaterals should not generally be excluded from thrombectomy. | Gabriel Broocks Andre Kemmling Tobias Faizy Rosalie McDonough Noel Van Horn Matthias Bechstein Lukas Meyer Gerhard Schon Jawed Nawabi Jens Fiehler Helge Kniep Uta Hanning | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 2 | Influence of mercury chloride on adenosine deaminase activity and gene expression in zebrafish ( Danio rerio ) brain显示文摘 | Mario Roberto Senger Denis Broock Rosemberg Kelly Juliana Seibt Renato Dutra Dias Maurício Reis Bogo Carla Denise Bonan | 2010 | Neurotoxicology2010，，3： | 1 |
| 3 | Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia显示文摘 | Backhaus J Junghanns K Broocks A | 2002 | J Psychosom Res2002，53，3： | 1 |
| 4 | Test–retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia显示文摘 | Backhaus J Junghanns K Broocks A Riemann D Hohagen F | 2002 | J Psychosom Res2002，53，： | 1 |
| 5 | Comparison of aerobic exercise, clomipramine, and placebo in the treatment of panic disorder显示文摘 | Broocks A Bandelow B Pekrun G | 1998 | Am J Psychiatry1998，155，5： | 1 |
| 6 | Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia显示文摘 | BACKHAUS J JUNGHANNS K BROOCKS A | 2002 | J Psychosom Res2002，53，3： | 1 |
| 7 | Screening and typing of Patagonian wine yeasts for glycosidase activities显示文摘 | RODR GUEZ M LOPES C BROOCK M | 2004 | J Appl Mierobiol2004，96，1： | 1 |
| 8 | Salivary total plasma and plasma free cortisol in panic disorder显示文摘 | Bandelow B Broocks A | 2000 | J Neural Transm2000，107，： | 1 |
| 9 | Comparison of aerobic ex- ercise, clomipramine, and placebo in the treatment of panic disorder 显示文摘 | Broocks A Bandelow B Pekrnn G | 1998 | Am J Psychiatry1998，155，5： | 1 |
| 10 | Search for atypical lymphocytes in schizophrenia 显示文摘 | Rudolf S Schlenke P Broocks A | 2004 | World J Biol Psychiatry2004，5，1： | 1 |
| 11 | Clinical outcome in patients with obsessive-compulsive disorder after discontinuation of SRI treatment: results from a two-year follow-up 显示文摘 | Kordon A Kahl KG Broocks A | 2005 | Eur Arch Psychiatry Clin Neurosci2005，255，1： | 1 |
| 12 | A Test for Independence Based on the Correlation Dimension显示文摘 | W A Broock J A Scheinkman W D Dechert B LeBaron | 1996 | Econometric Reviews1996，15，3： | 1 |
| 13 | Sporidiobolus longiusculus sp nov and sporobo-lomyces patagonicua sp nov novelye&sts of the sporidiobolales isolated from aquatic environmants in Patagonia Argentina显示文摘 | LIBKIND D GADANHO M BROOCK M V | 2005 | International Journal of Systematic and Evolutionary Microbiology2005，55，： | 1 |
| 14 | Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia显示文摘 | Backhaus J Junghanns K Broocks A | 2002 | J Psychosom Res2002，53，： | 1 |
| 15 | Test- retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia 显示文摘 | Backhaus J Junghanns K Broocks A | 2002 | J Psychosom Res2002，53，3： | 1 |
| 16 | Comparison of aerobic exercise, clomipramine, and placebo in the treatment of panic disorder显示文摘 | Broocks A Bandelow B Pekrun G | 1998 | American Journal of Psychiatry1998，155，60： | 1 |
| 17 | Test-retest re-liability and validity of the Pittsburgh Sleep Quality Index in primary insomnia显示文摘 | Backhaus J Junghanns K Broocks A | | 0，，3： | 1 |
| 18 | Early traumatic life events, parental rearing styles, family history of mental disorders, and birth risk factors in patients with social anxiety disorder显示文摘 | Prof. Dr. B. Bandelow A. Charimo Torrente Dr. D. Wedekind Prof. Dr. A. Broocks Prof. Dr. G. Hajak Prof. Dr. E. Rüther | 2004 | European Archives of Psychiatry and Clinical Neuroscience2004，，6： | 1 |
| 19 | Saccharomyces cerevisiae wine yeast populations in a cold region in Argentinean Patagonia: a study at different fermentation scales显示文摘 | Lopes CA Van Broock M Querol A | 2002 | Journal of Applied Microbiology2002，93，4： | 1 |
| 20 | Test - retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia显示文摘 | Backhaus J Junghanns K Broocks A | 2002 | J Psychosom Res2002，53，3： | 1 |
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