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| 1 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | Photo- synthetic responses to light in seedlings of selected Amazonian and Australian rainforest tree species显示文摘 | LANGENHEIM J H OSMOND C B BROOKS A | 1984 | Oecologia1984，63，： | 1 |
| 4 | Properties of porous media affecting fluid flow 显示文摘 | Brooks R H Corey A T | 1966 | Journal of Irrigation DrainageDivision1966，72，2： | 1 |
| 5 | Insecticide resistancein the malarial mosquito Anopheles arabiensis and associationwith the kdr mutation显示文摘 | Matambo TS Abdalla H Brooke BD | 2007 | Med Vet Entomol2007，21，1： | 1 |
| 6 | Ecoregion-based local volume equations for Appalachian hardwoods显示文摘 | Brooks J R Wiant H V | 2008 | Northern Journal of Applied Forestry2008，25，2： | 1 |
| 7 | Muscle fiber types: how many and what kind 显示文摘 | Brooke M H Kaiser K K | 1970 | Archives of Neurology1970，23，： | 1 |
| 8 | Performance of a rapid phage -based test, Fastplaque TB, to diagnose puhnotlary tuberculosis from sputum specimens in South Africa显示文摘 | Albert H Heydenrych N Brookes R | 2002 | Int J Tubere Lung Dis2002，6，6： | 1 |
| 9 | Site-specific insertion of genes into integrons: role of the 59-base element and determination of the recombination cross over point 显示文摘 | Hall R M Brookes D E Stokes H W | 1991 | Journal of Molecular Microbiology and Biotechnology1991，5，8： | 1 |
| 10 | Global burden of respiratory infections due to seasonal influenza in Young Children:a systematic review and meta-analysis显示文摘 | Nair H Brooks WA Katz W | 2011 | Lancet2011，378，9807： | 1 |
| 11 | Muscle fiber types: How many and what kind显示文摘 | Brooke M H Kaiser K K | 1970 | Arch Neurol1970，23，4： | 1 |
| 12 | Whole rock aminostratigraphy of the Coorong Coastal Plain, South Australia towards a 1 million year record of sea-level high- stands显示文摘 | Murray-Wallace C V Brooke B P Cann J H | 2001 | Journal of the Geological Society of London2001，158，： | 1 |
| 13 | Cell saver use in obstetrics显示文摘 | Malik S Brooks H Singhal T | 2010 | J Obstet Gynaecol2010，30，8： | 1 |
| 14 | IL-21 is required to control chronic viral infection显示文摘 | Elsaesser H Sauer K Brooks DG | 2009 | Science2009，324，5934： | 1 |
| 15 | Effect of Al and Ca addition on the copper catalysed formation of silanes from Si and CH3 CI 显示文摘 | BROOKES K H SIDDIQUIM R H RONG H M | 2001 | Appl Catal A: Gen2001，206，2： | 1 |
| 16 | Colloidal particle exchange between stream and stream bed in a laboratory flume 显示文摘 | Packman A I Brooks N H | 1995 | Marine andFreshwater Research1995，46，1： | 1 |
| 17 | Highly bioactive silver and silver/titania composite films grown by chemical vapour deposition显示文摘 | Brook L A Evans P Foster H A Pemble M E | 2007 | Journal of Photochemistry and Photobiology A:Chemistry2007，187，1： | 1 |
| 18 | Insecticide resistance in the malarial mosquito Anopheles arabiensis and association with the kdr mutation显示文摘 | Matambo TS Abdalla H Brooke BD | 2007 | Med Vet Entomo12007，21，1： | 1 |
| 19 | The formation of graphiti- zing carbons from the liquid phase显示文摘 | Brooks J D Taylor G H | 1965 | Carbon1965，4，1： | 1 |
| 20 | Studies on uptake of heavy metals by the Scandinavian 'kisplanten' Lychnis alpina and Silene dioica显示文摘 | Brooks R R Crooks H M | 1980 | Plant and Soil1980，54，： | 1 |
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