维普中文期刊产品整合服务

Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up

查看全文 作　　者：Ahmed Z [1]Elmaadawi;Peter S [2]Jensen;L Eugene [3]Arnold;Brooke SG [4]Molina;Lily [5]Hechtman;Howard B [6]Abikoff;Stephen P [7]Hinshaw;Jeffrey H [8]Newcorn;Laurence Lee [9]Greenhill;James M [10]Swanson;Cathryn A [11]Galanter 高影响力作者 机构地区：[1]Department of Psychiatry, Indiana University School of Medicine-South Bend Campus;[2]REACH Institute;[3]Department of Psychiatry, Ohio State University;[4]Department of Psychiatry, University of Pittsburgh;[5]Department of Psychiatry and Pediatrics, McGill University Health Center;[6]Department of Child and Adolescent Psychiatry, The Child Study Center at NYU Langone Medical Center;[7]Department of Psychology, University of California;[8]Department of Psychiatry and Pediatrics, Icahn School of Medicine at Mount Sinai;[9]Department of Clinical Child and Adolescent Psychiatry, New York Psychiatric Institute;[10]Department of Pediatrics and Epidemiology, Child Development Center, University of California;[11]Department of Psychiatry, State University of New York Downstate Medical Center and Kings County Hospital Center高影响力机构 出　　处：《World Journal of Psychiatry》索引2015年第5卷第4期,共13页高影响力期刊 摘　　要：AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. 关 键 词：Multimodal treatment study of ATTENTION DEFICIT HYPERACTIVITY DISORDER IRRITABILITY ATTENTION DEFICIT HYPERACTIVITY DISORDER Diagnostic interview schedule for CHILDREN Bipolar DISORDER
相关文献

参考文献(46)

引证文献(3)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费