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| 1 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 2 | How does a real-world child psychiatric clinic diagnose and treat attention deficit hyperactivity disorder?显示文摘AIM: To investigate child and adolescent psychiatrists'(CAPs) attention deficit hyperactivity disorder(ADHD) and oppositional defiant disorder(ODD) diagnoses and treatments in real-world clinical practice. METHODS: The medical records of 69 ADHD children(mean age = 9.5 years), newly referred to the ADHD clinic, were reviewed for their scores of parent- and teacher-reported Vanderbilt ADHD Diagnostic Rating Scales(VADRSs), CAPs' diagnoses of ADHD and ODD, and CAPs' treatment recommendations. Among 63 ADHD subjects who completed both parent and teacher VADRSs, we examined the agreement of the parent and teacher VADRSs. We also examined the concurrent validity of CAPs' ODD diagnoses against the results from the VADRSs. In addition, we compared CAPs' treatment recommendations against established ADHD and ODD guidelines.RESULTS: Among 63 ADHD subjects, the majority of the subjects(92%) met full ADHD diagnostic criteria at least in one setting(parent or teacher) on the VADRSs. Nearly half of the patients met full ADHD diagnostic criteria in two settings(parent and teacher). Relatively low agreement between the parent and teacher VADRSs were found(95%CI:-0.33 to 0.14). For 29 children who scored positive for ODD on the rating scales, CAPs confirmed the ODD diagnosis in only 12 of these casepositives, which is considered as a fair agreement between CAPs and VADRSs(95%CI: 0.10-0.53). For 27 children with no ODD diagnosis made by either CAP or VADRS, more than half of them were recommended for medication only. In contrast, where CAPs made the diagnosis of ODD, or where the parent or teacher VADRS was positive for ODD, almost all of the patients received recommendations for medication and behavior therapy.CONCLUSION: CAPs' ADHD diagnoses have strong concurrent validity against valid rating scales, but ADHD's most common comorbid condition- ODD- may be underrecognized. | Kumi Yuki Jyoti Bhagia David Mrazek Peter S Jensen | 2016 | World Journal of Psychiatry2016，6，1： | 2 |
| 3 | Application of the health risk assessment of acetochlor in the development of water quality criteria显示文摘Acetochlor is a widely used herbicide in agricultural production. Studies have shown that acetochlor has obvious environmental hormone effects, and long-term exposure may pose a threat to human health. To quantify the hazards of acetochlor in drinking water, a health risk assessment of acetochlor was conducted in major cities of China based on the data of acetochlor residue concentrations in drinking water. The approach of the Species Sensitivity Distributions(SSD) method is used to extrapolate from animal testing data to reflect worst case human toxicity. Results show that hazard quotients related to acetochlor residues in drinking water for different age groups range from 1.94 × 10-4 to 6.13 × 10-4, so, there are no indication of human risk. Compared to the total estimated hazard quotient from oral intake of acetochlor, the chronic exposure imputed to acetochlor residues in drinking water in China accounts for 0.4%. This paper recommends 0.02 mg/L to be the maximum acetochlor residue concentration level in drinking water and source water criteria. | Wei An Chenhui Sang Kristian Marienlund Jensen Peter Borgen Sørensen Bin Zhang Min Yang | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 4 | Phthalates and Perfluorooctanesulfonic Acid in Human Amniotic Fluid: Temporal Trends and Timing of Amniocentesis in Pregnancy显示文摘 | Jensen Morten S?ndergaard N?rgaard-Pedersen Bent Toft Gunnar Hougaard David M Bonde Jens Peter Cohen Arieh Thulstrup Ane Marie Ivell Richard Anand-Ivell Ravinder Lindh Christian H J?nsson Bo A G | 2012 | EN2012，，6： | 1 |
| 5 | Descending Inhibitory Pain Modulation Is Impaired in Patients With Chronic Pancreatitis显示文摘 | S?ren Schou Olesen Christina Brock Anne Lund Krarup Peter Funch–Jensen Lars Arendt–Nielsen Oliver H. Wilder–Smith Asbj?rn Mohr Drewes | 2010 | Clinical Gastroenterology and Hepatology2010，，8： | 1 |
| 6 | Mutated Desmoglein‐2 Proteins are Incorporated into Desmosomes and Exhibit Dominant‐Negative Effects in Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | Torsten B. Rasmussen Johan Palmfeldt Peter H. Nissen Raffaela Magnoni S?ren Dalager Uffe B. Jensen Won Y. Kim Lene Heickendorff Henning M?lgaard Henrik K. Jensen Ulrik T. Baandrup Peter Bross Jens Mogensen | 2013 | Human Mutation2013，，5： | 1 |
| 7 | An Adaptive Extended Kalman Filter for Target Image Tracking显示文摘 | Maybeck Robert L Jensen | 1981 | IEEE Transactions on Aerospace and Electronic Systems1981，17，2： | 1 |
| 8 | Oxy-fuel combustion of millimeter-sized coal char: Particle temperatures and NO formation显示文摘 | Jacob Brix Leyre Gómez Navascués Joachim Bachmann Nielsen Peter L?vengreen Bonnek Henning Engelbrecht Larsen S?nnik Clausen Peter Glarborg Anker Degn Jensen | 2013 | Fuel2013，，： | 1 |
| 9 | Descending Inhibitory Pain Modulation Is Impaired in Patients With Chronic Pancreatitis显示文摘 | S?ren Schou Olesen Christina Brock Anne Lund Krarup Peter Funch–Jensen Lars Arendt–Nielsen Oliver H. Wilder–Smith Asbj?rn Mohr Drewes | 2010 | Clinical Gastroenterology and Hepatology2010，，8： | 1 |
| 10 | Descending Inhibitory Pain Modulation Is Impaired in Patients With Chronic Pancreatitis显示文摘 | S?ren Schou Olesen Christina Brock Anne Lund Krarup Peter Funch–Jensen Lars Arendt–Nielsen Oliver H. Wilder–Smith Asbj?rn Mohr Drewes | 2010 | Clinical Gastroenterology and Hepatology2010，，8： | 1 |
| 11 | Descending Inhibitory Pain Modulation Is Impaired in Patients With Chronic Pancreatitis显示文摘 | S?ren Schou Olesen Christina Brock Anne Lund Krarup Peter Funch–Jensen Lars Arendt–Nielsen Oliver H. Wilder–Smith Asbj?rn Mohr Drewes | 2010 | Clinical Gastroenterology and Hepatology2010，，8： | 1 |
| 12 | 低成本电弧喷涂替代堆焊案例分析研究显示文摘堆焊是一种常规的涂层制备方法,并且制备的涂层可以满足各种性能要求的需要。堆焊在工业中普遍应用,然而,他们有一个共同点,由于涂层制备速度的限制,导致成本相对较高。本文主要关注采用电弧喷涂替代MAG堆焊用于农业装备制造生产线的可行性,例如,耕作设备。与堆焊相比,采用电弧喷涂可以优化五种以上的生产工艺,减少多项生产工艺流程。本文主要目标是应用电弧喷涂工艺获得一个类似或更好的涂层质量。本文中制备的涂层材料重点是降低成本,提高生产效率,其目标是实现耕作设备在复杂耕作条件下具备更高的耐磨性。将涂覆有耐磨涂层的犁头在田间的测试是主要的评定方法。此外,该涂层将采用金相光学显微镜(LOM)和扫描电子显微镜(SEM)观察来解释和支持的现场试验研究结果。 | Peter Tommy Nielsen Carsten Jensen FORCE Technology Denmark Paul Br?sel M?lbro A/S 崔云涛 | 2014 | 热喷涂技术2014，0，4： | 0 |
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