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| 1 | Dual Resistance of Melon to Fusarium oxysporum Races 0 and 2 and to Papaya ring-spot virus is Controlled by a Pair of Head-to-Head-Oriented NB-LRR Genes of Unusual Architecture显示文摘Dear Editor, Potyviruses such as Papaya ring-spot virus (PRSV) cause important yield losses in cucurbits.Two distinct resistant alleles were identified in the Cucumis melo germplasm.Accession PI 414723 (Supplemental Table 1) possesses monogenic resistance,controlled by the Prv2 allele,and reacts to PRSV by systemic necrotic lesions;plants with the Prv1 allele,described in cultivar WMR-29,remain symptomless (Pitrat and Lecoq,1983).Fusarium oxysporum f.sp.melonis (FUS)exclusively attacks melon,causing severe wilt.Monogenic dominant resistance was described against races 0,1,and 2.The Fom-2 gene,controlling resistance to races 0 and 1,was cloned by Joobeur et al.(2004),and encodes a nucleotide binding domain (NB)-leucine rich repeat (LRR) protein.Our study focused on the Fom-1 gene,which confers resistance to races 0 and 2 (Risser et al.,1976),and on the Prv gene;the two are tightly linked on melon linkage group iX.Molecular markers were developed for the Fom-1/Prv locus,but no study has provided the resolution required for positional cloning. | Yariv Brotman Michael Normantovich Zachi Goldenberg Zvi Zvirin Irina Kovalski Nastacia Stovbun Tirza Doniger Anthony M. Bolqer Christelle Troadec Abdelhafid Bendahman~ RoniCohen Nurit Katzir Michel Pitrat Catherine Dogimont Rafael PerI-Treves | 2013 | Molecular Plant2013，6，1： | 9 |
| 2 | The LysM Receptor-Like Kinase LysM RLK1 Is Required to Activate Defense and Abiotic-Stress Responses Induced by Overexpression of Fungal Chitinases in Arabidopsis Plants显示文摘到 Arabidopsis 幼苗的螃蟹壳几丁质或 pentamer 几丁质 oligosaccharide 的申请增加了忍耐到咸度在野类型然而并非在 LysM 像受体的 Kinase1 (CERK1/LysM RLK1 ) 的猛烈异种基因,知道在表明外长的几丁质导致的防卫回答起一个关键作用。从真菌 Trichoderma asperelleoides T203 的 endochitinase chit36 和 hexoaminidase excy1 基因显示出的 Arabidopsis 植物 overexpressing 增加了忍耐到咸度,重金属的压力,和 Botrytis cinerea 感染。抵抗的线, overexpressing 在不同层次的真菌的 chitinases,是到 lysm rlk1 异种的 outcrossed。独立同型结合的混血儿失去了抵抗到关於生命、不能生活的压力,尽管有提高的 chitinase 活动。 270 压力相关的基因的表示分析包括反应的氧种类( ROS )和几丁质导致的那些,揭示经常的起来规定(至少双重) 10 ,在 chitinase-overexpressing 的基因排队并且一另外其表情没在怀有变化的 lysm rlk1 大美人异种或混血儿被提高的 76 导致盐的基因。这些调查结果阐明那个导致几丁质的发信号由 LysM RLK1 调停了受体没被限制到关於生命的压力反应而且包含不能生活压力的发信号和罐头被 chitinases 的宫外的表示在植物传送。 | Yariv Brotman Udi Landau Smadar Pnini Jan Lisec Salma Balazadeh Bernd Mueller-Roeber Aviah Zilberstein Lothar Willmitzer Ilan Chet Ada Viterbo | 2012 | Molecular Plant2012，5，5： | 5 |
| 3 | Mapping theArabidopsis Metabolic Landscape by Untargeted Metabolomics at Different Environmental Conditions显示文摘新陈代谢的染色体宽的协会研究(mGWAS ) ,因此,代谢物层次被认为是特点,帮助能解开新陈代谢的网络的基因基础。309 Arabidopsis 就职的一个总数在二个独立环境条件(控制和应力) 下面被种并且使遭到到介绍的 untargeted LC-MS-based metabolomic;获得的吸水的代谢物的层次在 GWAS 被使用。我们为超过 3000 半极的代谢物的 two-condition-based GWAS 导致了 123 高度解决的代谢物的察觉量的特点 loci ?(p 1.0E-08 ) 。有趣地,不同地,从在 Arabidopsis 主要代谢物,趋于被很多小效果的 loci 控制,的自然变化,我们在发现几个学生大效果的 loci 控制第二等的代谢物的变化的小效果的 loci 的一个广阔数字。two-condition-based GWAS 被集成用一个时间功课压力实验与导出网络的代谢物抄本关联跟随。通过这条综合途径,我们选择了在结构的基因和代谢物之间的 70 个关键候选人协会,并且试验性地验证了八个新奇协会,他们中的二个在二环境的出现微分基因规定学习了。我们表明联合有 time-course-derived 网络的基于 metabolomics 的 GWAS 两个都为识别代谢物基因协会在不同不能生活的环境下面执行了的大规模 untargeted 的力量,提供进 Arabidopsis 的新陈代谢的风景的新奇全球卓见。 | Si Wu Takayuki Tohge Alvaro Cuadros-lnostroza Hao Tong Hezi Tenenboim Rik Kooke Michael Meret Joost B. Keurentjes Zoran Nikoloski Alisdair R. Fernie Lothar Willmitzer Yariv Brotman | 2018 | Molecular Plant2018，11，1： | 3 |
| 4 | Lipidomic and transcriptomic analysis reveals reallocation of carbon flux from cuticular wax into plastid membrane lipids in a glossy“Newhall”navel orange mutant显示文摘Both cuticle and membrane lipids play essential roles in quality maintenance and disease resistance in fresh fruits.Many reports have indicated the modification of alternative branch pathways in epicuticular wax mutants;however,the specific alterations concerning lipids have not been clarified thus far.Here,we conducted a comprehensive,timeresolved lipidomic,and transcriptomic analysis on the“Newhall”navel orange(WT)and its glossy mutant(MT)“Gannan No.1”.The results revealed severely suppressed wax formation accompanied by significantly elevated production of 36-carbon plastid lipids with increasing fruit maturation in MT.Transcriptomics analysis further identified a series of key functional enzymes and transcription factors putatively involved in the biosynthesis pathways of wax and membrane lipids.Moreover,the high accumulation of jasmonic acid(JA)in MT was possibly due to the need to maintain plastid lipid homeostasis,as the expression levels of two significantly upregulated lipases(CsDAD1 and CsDALL2)were positively correlated with plastid lipids and characterized to hydrolyze plastid lipids to increase the JA content.Our results will provide new insights into the molecular mechanisms underlying the natural variation of plant lipids to lay a foundation for the quality improvement of citrus fruit. | Haoliang Wan Hongbo Liu Jingyu Zhang Yi Lyu Zhuoran Li Yizhong He Xiaoliang Zhang Xiuxin Deng Yariv Brotman Alisdair RFernie Yunjiang Cheng Weiwei Wen | 2020 | Horticulture Research2020，7，1： | 2 |
| 5 | Quantitative Trait Loci Analysis Identifies a Prominent Gene Involved in the Production of Fatty Acid-Derived Flavor Volatiles in Tomato显示文摘到进在西红柿的类脂化合物新陈代谢的基因规定的获得卓见,我们进行了跟随水果果皮和茄属 pennellii 基因渗入的叶织物介绍的 lipidomic 的分析衬里的新陈代谢的特点 loci (mQTL )(IL ) 。提高为选择水果特定的 mQTL 印射分辨率,我们在独立地导出的 S 的一个子集介绍了类脂化合物。pennellii 回交生来的线,以及在 near-isogenic sub-IL ? 人口。我们识别了控制班 III 脂肪分解酵素家庭, LIP1 和 LIP2 的几类脂化合物,和二个成员的层次的通常认为的 lecithin:cholesterol acyltransferase,那与 diacylglycerols (DAG ) 和 triacylglycerols (标签) 的减少的层次被联系。这个班的脂肪分解酵素从 acylglycerols 的甘油脊梁劈开丰满的酸。释放的丰满的酸用作风味 volatiles 的先锋。我们证明那 LIP1 表情与丰满的导出酸的不稳定的层次相关。我们进一步用转基因的植物在标签和 DAG 故障和不稳定的合成证实 LIP1 的功能。一起拿,我们的学习广泛地在西红柿描绘了脂性的混合物的基因建筑学并且在分子的水平证明从甘油脊梁的免费的丰满的酸的版本能在下游地不稳定的合成上有主要影响。 | Karolina Garbowicz Zhongyuan Liu Saleh Alseekh Denise Tieman Mark Taylor Anastasiya Kuhalskaya Itai Ofner Dani Zamir Harry J. Klee Alisdair R. Fernie Yariv Brotman | 2018 | Molecular Plant2018，11，9： | 2 |
| 6 | Personal Hygienic Behaviors and Bacterial Vaginosis显示文摘 | Mark A. Klebanoff Tonja R. Nansel Rebecca M. Brotman Jun Zhang Kai-Fun Yu Jane R. Schwebke William W. Andrews | 2010 | Sexually Transmitted Diseases2010，，2： | 1 |
| 7 | The cardiovascular toll of stress显示文摘 | BROTMAN D J GOLDEN S H WITTSTEIN I S | 2007 | Lancet2007，370，： | 1 |
| 8 | Why do women douche? A longitudinal study with two analytic approaches 显示文摘 | Brotman RM Klebanoff MA Nansel T | 2008 | Ann Epidemiol2008，18，1： | 1 |
| 9 | Trial of fluoxtine addrd to neuroleptics for treatment-resistant schizophrenic patients显示文摘 | Golf D C Brotman A W Waitrs M | 1990 | Am J Psychiatry1990，147，4： | 1 |
| 10 | Should patients on warfarin for 3 months for idiopathic proximal deep venous thrombosis receive bridging therapy precolonscopy(with expected biopsy)? 显示文摘 | Brotman D J Kaatz S | 2003 | Med Clin North Am2003，87，6： | 1 |
| 11 | Linkage map of Cucumis melo including phenotypic traits and sequence-character- ized genes显示文摘 | SILBERSTEIN L KOVALSKI I BROTMAN Y | 2003 | Genome2003，46，： | 1 |
| 12 | Low-molecular-weight-heparins as periprocedural anticoagulation for patients on long-term warfarin therapy:a standardized bridging therapy protocol显示文摘 | Jaffer AK Ahmed M Brotman DJ | 2005 | J Thromb Thrombolysis2005，20，1： | 1 |
| 13 | Infectivity of blood from PCR-positive,HBsAg-negative,anti-HBs-positive cases of resovled hepatitis B infection显示文摘 | Prince AM Lee D-H Brotman B | 2001 | Transfusion2001，41，6： | 1 |
| 14 | Breast conservation:safe for early breast cancer 显示文摘 | Bar-Sella G Fried G Brotman Z | 1999 | Harefuah1999，137，78： | 1 |
| 15 | Significance of the anti-E2 response in self-limited and chronic hepatitis C virus infectious in chimpanzees and in humans显示文摘 | Prince A M Brotman B Lee D H Ren L Moore B S Scheffel J W | | 0，，04： | 1 |
| 16 | Hospital-acquired gastrointestinal Bleeding outside the critical care unit显示文摘 | Qadeer MA Richter JE Brotman DJ | | 0，，01： | 1 |
| 17 | Perioperative statins:more than lipid-lowering显示文摘 | Feldman LS Brotman DJ | | 0，，： | 1 |
| 18 | Involvement of the Hexose Transporter Gene LeHT1 and of Sugars in Resistance of Tomato to Tomato Yellow Leaf Curl Virus显示文摘Dear Editor, Tomato yellow leaf curl virus (TYLCV) is a whitefly-transmitted geminivirus infecting tomato crops (Czosnek,2007).TYLCV-resistant (R) and susceptible (S) lines with the same genetic background have been bred using Solanum habrochaites as the resistance source.The gene(s) conferring resistance are unknown.Previously,we demonstrated that the hexose transpcrter gene LeHT1 is up-regulated upon infection in R plants and its silencing in R plants (RH) leads to the collapse of resistance (Eybishtz et al.,2010).To uncover the role of LeHT1 in resistance,we (1) analyzed the transcriptome reprogramming in leaves of S,R,and RH plants using a homedesigned microarray,before and 7 d after TYLCV inoculation (0,7 dpi),and (2) measured the concentration of sugars and their derivatives in S,R,and RH leaves at 1 and 7 dpi because LeHTI is transporting both glucose and fructose (McCurdy et al.,2010). | Dagan Sade Yariv Brotman Assa f Eybishtz Alvaro Cuadros-lnostroza Alisdair R. Fernie Lothar Willmitzer Henry Czosnek | 2013 | Molecular Plant2013，6，5： | 1 |
| 19 | Molecular markers linked to papaya ring spot virus resistance and Fuasrium race 2 resistance in melon显示文摘 | BROTMAN Y KOVALSKI I DOGIMONT C | 2005 | Theoretical and Applied Genetics2005，110，2： | 1 |
| 20 | Heart rate variability predicts ESRD and CKD-related hospitalization显示文摘 | Brotman DJ Bash LD Qayyum R | 2010 | J Am Soc Nephrol2010，21，9： | 1 |
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