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| 1 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 2 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 3 | Al_3Zr和Al_3Nb作为铝合金晶粒细化剂的晶体学研究(英文)显示文摘利用edge-to-edge matching模型从晶体学角度研究Al3Zr和Al3Nb两种金属间化合物作为铝合金晶粒细化剂的有效性。结果表明,Al3Zr和Al3Nb两种金属间化合物和铝之间的原子间距错配和面间距错配值都很小。此外,模型预测Al3Zr和Al3Nb两种金属间化合物与铝之间存在良好的晶粒取向关系。根据模型理论可以从晶体学角度证明这两种金属间化合物对铝合金是有效的晶粒异质形核细化剂。本晶体学研究为包晶铝合金Al-Zr和Al-Nb中出现的明显晶粒细化现象提供了合理解释,同时为理解晶粒细化机理提供了新方法。 | 汪锋 邱冬 刘峙麟 John TAYLOR Mark EASTON 张明星 | 2014 | Transactions of Nonferrous Metals Society of China2014，24，7： | 4 |
| 4 | Catabolism of Branched Chain Amino Acids Supports Respiration but Not Volatile Synthesis in Tomato Fruits显示文摘分支链氨基酸 transaminases (BCAT ) 在分支链氨基酸白氨酸,异白氨酸,和缬氨酸的新陈代谢有一个关键角色。这些酶催化合成的最后步和这些氨基酸的降级的起始的步。尽管在植物的分叉的链氨基酸的 biosynthetic 小径广泛地被调查了,很多基因被描绘了,他们在植物的分解代谢完全还没被理解。我们以前在西红柿描绘了分叉的链氨基酸 transaminase 基因家庭,揭示 subcellular 本地化和六基因编码的酶的运动性质。这里,我们在水果开发期间检验了酶的可能的功能。我们进一步描绘了在分叉的链氨基酸 transaminases 的表示不同的转基因的植物 1 和 3,在线 overexpressing 任何一个 BCAT1 或 BCAT3 在在 BCAT1 和 volatiles 的层次缺乏的水果评估呼吸的率。我们测试的份量上经由喂实验的先锋和同位素,在水果 volatiles 的形成的分叉的链氨基酸和他们的相应 keto 酸的重要性。我们的结果不仅第一次在水果呼吸表明分叉的链氨基酸的重要性,而且揭示那 keto 酸,而非氨基酸,是为分叉的链风味 volatiles 的可能的先锋。 | Andrej Kochevenko Wagner L. Araujo Gregory S. Maloney Denise M. Tieman Phuc Thi Do Mark G. Taylor Harry J. Klee Alisdair R. Fernie | 2012 | Molecular Plant2012，5，2： | 4 |
| 5 | Quantitative Trait Loci Analysis Identifies a Prominent Gene Involved in the Production of Fatty Acid-Derived Flavor Volatiles in Tomato显示文摘到进在西红柿的类脂化合物新陈代谢的基因规定的获得卓见,我们进行了跟随水果果皮和茄属 pennellii 基因渗入的叶织物介绍的 lipidomic 的分析衬里的新陈代谢的特点 loci (mQTL )(IL ) 。提高为选择水果特定的 mQTL 印射分辨率,我们在独立地导出的 S 的一个子集介绍了类脂化合物。pennellii 回交生来的线,以及在 near-isogenic sub-IL ? 人口。我们识别了控制班 III 脂肪分解酵素家庭, LIP1 和 LIP2 的几类脂化合物,和二个成员的层次的通常认为的 lecithin:cholesterol acyltransferase,那与 diacylglycerols (DAG ) 和 triacylglycerols (标签) 的减少的层次被联系。这个班的脂肪分解酵素从 acylglycerols 的甘油脊梁劈开丰满的酸。释放的丰满的酸用作风味 volatiles 的先锋。我们证明那 LIP1 表情与丰满的导出酸的不稳定的层次相关。我们进一步用转基因的植物在标签和 DAG 故障和不稳定的合成证实 LIP1 的功能。一起拿,我们的学习广泛地在西红柿描绘了脂性的混合物的基因建筑学并且在分子的水平证明从甘油脊梁的免费的丰满的酸的版本能在下游地不稳定的合成上有主要影响。 | Karolina Garbowicz Zhongyuan Liu Saleh Alseekh Denise Tieman Mark Taylor Anastasiya Kuhalskaya Itai Ofner Dani Zamir Harry J. Klee Alisdair R. Fernie Yariv Brotman | 2018 | Molecular Plant2018，11，9： | 2 |
| 6 | Revisiting the role of peritectics in grain refinement of Al alloys显示文摘 | Feng Wang Zhilin Liu Dong Qiu John A. Taylor Mark A. Easton Ming-Xing Zhang | 2013 | Acta Materialia2013，，1： | 2 |
| 7 | Six Hundred Fifty Consecutive Pancreaticoduodenectomies in the 1990s: Pathology, Complications, and Outcomes显示文摘 | Charles J. Yeo John L. Cameron Taylor A. Sohn Keith D. Lillemoe Henry A. Pitt Mark A. Talamini Ralph H. Hruban Sarah E. Ord Patricia K. Sauter JoAnn Coleman Marianna L. Zahurak Louise B. Grochow Ross A. Abrams | 1997 | Annals of Surgery1997，，3： | 2 |
| 8 | Myocardial endothelin-1 release and indices of inflammation during angioplasty for acute myocardial infarction and stable coronary artery disease显示文摘 | Andrew J. Taylor Alex Bobik Mark Richards David Kaye Geoffrey Raines Paul Gould Garry Jennings | 2004 | American Heart Journal2004，，2： | 2 |
| 9 | The CNS phenotype of X-linked Charcot-Marie-Tooth disease-More than a peripheral problem显示文摘 | Simon EM Marks HE | 2003 | Neurology2003，61，： | 1 |
| 10 | Metabolic engineering of carotenoid biosynthesis in plants显示文摘 | Giovanni Giuliano Raffaela Tavazza Gianfranco Diretto Peter Beyer Mark A. Taylor | 2008 | Trends in Biotechnology2008，，3： | 1 |
| 11 | Deep brain stimulation for refractory obsessive-compulsive disorder显示文摘 | James L. Abelson George C. Curtis Oren Sagher Ronald C. Albucher Mark Harrigan Stephan F. Taylor Brian Martis Bruno Giordani | 2005 | Biological Psychiatry2005，，5： | 1 |
| 12 | Pharmacokinetics of an Oral Drug(Acetaminophen) Administered at Various Times in Relation to Subcutaneous Injection of Exenatide (Exendin-4) in Healthy Subjects显示文摘 | Erich Blase Kristin Taylor Hong-ye Gao Matthew Wintle Mark Fineman | 2005 | The Journal Of Clinical Pharmacology2005，，5： | 1 |
| 13 | Clinical use of a rapid collagen binding assay for yon Willebrand factor cleaaaving protease in patients with thromboeytopenic purpura显示文摘 | Margaret E Rick Stephan Moll Mark A Taylor | 2002 | ThrombHaemost2002，88，： | 1 |
| 14 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 15 | Effects of composition and granulometry on thermal conductivity of anode cover materials显示文摘 | Hasini Wijayaratne Margaret Hyland Mark Taylor | | 0，，： | 1 |
| 16 | ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography显示文摘 | Allen J. Taylor Manuel Cerqueira John McB. Hodgson Daniel Mark James Min Patrick O’Gara Geoffrey D. Rubin | 2010 | Journal of the American College of Cardiology2010，，22： | 1 |
| 17 | Licenced to pollute but not to poison: The ineffectiveness of regulatory authorities at protecting public health from atmospheric arsenic, lead and other contaminants resulting from mining and smelting operations显示文摘 | Mark Patrick Taylor Peter J. Davies Louise Jane Kristensen Janae Lynn Csavina | 2014 | Aeolian Research2014，，： | 1 |
| 18 | Gastric cancer and H pylori 显示文摘 | Dawsey SM Mark SD Taylor PR | 2002 | Gut2002，51，3： | 1 |
| 19 | ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Sur显示文摘 | Alan T. Hirsch Ziv J. Haskal Norman R. Hertzer Curtis W. Bakal Mark A. Creager Jonathan L. Halperin Loren F. Hiratzka William R.C. Murphy Jeffrey W. Olin Jules B. Puschett Kenneth A. Rosenfield David Sacks James C. Stanley Lloyd M. Taylor Christopher J. W | 2006 | Circulation2006，，11： | 1 |
| 20 | Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients显示文摘 | Judith Jacobi Nicholas Bircher James Krinsley Michael Agus Susan S. Braithwaite Clifford Deutschman Amado X. Freire Douglas Geehan Benjamin Kohl Stanley A. Nasraway Mark Rigby Karen Sands Lynn Schallom Beth Taylor Guillermo Umpierrez John Mazuski Holger S | 2012 | Critical Care Medicine2012，，12： | 1 |
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