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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Analysis of feline calicivirus capsid protein genes:identification of varia ble antigenic determinant regions of the protein显示文摘 | Bruce S S Julia F R William L M | 1993 | J Gen Virol1993，74，： | 1 |
| 3 | Economic incentives for agricultural nonpoint source pollution control显示文摘 | Bruce A L Marc R | 1994 | Water Resources Bulletin1994，30，3： | 1 |
| 4 | The Profession:Public Intrests andCommom Good显示文摘 | Bruce J Callahan D Wolf S M | 1987 | Hasting Center Report1987，，： | 1 |
| 5 | Hot-cor- rosion Resistance of Ni-Cr-A1-Y and Ni-18 % Si SI- loys in Sulfate Eutectic and Sulfate Plus Vanadate Melts at 973 K 显示文摘 | BRUCE M W FRED S P GERALD H M | 2002 | Oxidation of Metals2002，58，56： | 1 |
| 6 | FromSARS to 2009 H1N1 influenza:the evolution ofa public health incident management systemat CDC显示文摘 | Papagiotas SS Frank M Bruce S | 2012 | Public Health Reports2012，127，3： | 1 |
| 7 | Methodology for Thermal Evaluation of Multichip Modules 显示文摘 | Lall Balwant S Guenin Bruce M Molnar Ronald J | 1995 | IEEE Trans Comp Packg Manufa Technol Part A1995，18，4： | 1 |
| 8 | Automated detection of subpixel hyperspectral targets with continuous and discrete wavelet 显示文摘 | Bruce L M Morgan C Larsen S | 2001 | IEEE Transaction on Geoscience and Remote Sensing2001，39，10： | 1 |
| 9 | Spontaneous gallbladder perforation in a neonate显示文摘 | Gull S Singh M Bruce J | 2005 | Pediatr Surg Int2005，21，8： | 1 |
| 10 | Bioabatement to remove inhibitors from biomass-derived sugar hydrolysates 显示文摘 | Nichols Nancy N Dienr Bruce S Guis aoo Gema M | 2005 | Apphed Biochemistry and Biotechnology2005，，： | 1 |
| 11 | Purification and primary structural charaeterization of prophenoloxidases from Aedes aegypti larvae显示文摘 | Junsuo S L Seong R K Bruce M C | 2005 | Insect Biochem Mol Biol2005，35，： | 1 |
| 12 | PPARγ: A nuclear regulator of metabolism, differentiation, and cell growth显示文摘 | Evan D R Bruce M S | 2001 | J Biol Chem2001，276，37： | 1 |
| 13 | Radio{re- quency ablation (coblation): a promising new tech- nique {or laryngeal papillomata显示文摘 | TIMMS M S BRUCE I A PATEL N K | 2007 | J Laryngol Otol2007，121，： | 1 |
| 14 | Propofol and methohexital have no significant effect on mucus secretion or clearance in the anesthetized dog显示文摘 | RPREET S BRUCE K RUBIN M | 2001 | Crit Care Med2001，29，5： | 1 |
| 15 | Calcium nephrolithiasis; effect of water hardness on urinary electrolytes 显示文摘 | Schwartz B F Schenkman N S Bruce J E Leslie S W Stoller M L | 2002 | Urology2002，60，： | 1 |
| 16 | Increased myocardial perfusion and sympathoadrenal activation during mild core hypothermia in awake humans显示文摘 | Frank S M Satitpunwaycha P Bruce S R | 2003 | Clinical Science2003，104，5： | 1 |
| 17 | The role of accounting conservatism in mitigating bondholdershareholder conflicts over dividends policy and in reducing debt costs显示文摘 | Ahmed A S Bruce K B Morton R M | 2002 | The Accounting Review2002，77，4： | 1 |
| 18 | Regulation of crustacean molting:A multi-hormonal system显示文摘 | Chang E S Bruce M J Tamone S L | 1993 | Am Zool1993，33，3： | 1 |
| 19 | Emerging chemicals of concern: Pharmaceuticals and personal care products (PPCPs) in Asia, with particular reference to Southern China 显示文摘 | Bruce J R Paul K S L Michael M | 2005 | Marine Pollution Bulletin2005，0，： | 1 |
| 20 | Assessing damages for non-performance of a travel professional--a suggest-ed use of'SERVQUAL'显示文摘 | Richard M Howey | 2001 | Tourism Management2001，22，： | 1 |
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