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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 3 | Locking versus nonlocking T-plates for dorsally and volar fixation of dorsally comminuted distal radius fractures: a biomechanical study 显示文摘 | Correy T Terence M Bruce T | 2005 | The Journal of Hand Surgery2005，30，4： | 1 |
| 4 | Learning subjective language 显示文摘 | Wiebe J Wilson T Bruce R Bell M Martin M | 2004 | Computational linguistics2004，30，3： | 1 |
| 5 | Insect host location : a volatile situation 显示文摘 | Bruce T J A Wadhams L J Woodcock C M | 2005 | Trends in Plant Science2005，10，6： | 1 |
| 6 | Improving bleachability of radiata pine kraft pulps following treatment with hemicellulolytic enzymes显示文摘 | Clark T A Steward D Bruce M E | 1991 | Appita1991，44，6： | 1 |
| 7 | Insect host location:A volatile situation 显示文摘 | Bruce T J A Wadhams L J Woodcock C M | 2005 | Trends in Plant Sciences2005，10，： | 1 |
| 8 | Rainbow trout rearing performance, intestinal morphology, and immune response after long-term feeding of high levels of fermented soybean meal显示文摘 | Barnes M E Brown M L Bruce T | 2014 | Aquacuhure2014，76，4： | 1 |
| 9 | Heat transfer enhancement in Ferro fluids subjected to steady magnetic fields显示文摘 | CHITINI T BRUCE A F JOHN M | | 0，，201： | 1 |
| 10 | Food scares and trust:a european study显示文摘 | MARIO M ALEXANDRA L BRUCE T W | 2008 | Journal of Agricultural Eco-nomics2008，59，1： | 1 |
| 11 | Response of economi-cally important aphids to components of Hemizygia petiolataesse-ntial oil显示文摘 | Bruce T J Birkett M A Blande J | 2005 | Pest Management Science2005，61，： | 1 |
| 12 | Behavioural responses of the maize weevil,Sitophilus zeama/s,to host (maize grain) and non-host plant volatiles显示文摘 | Ukeh D A Birkett M A Bruce T J A et a/ | 2010 | Pest Management Science2010，66，1： | 1 |
| 13 | Improving bleachability of radiata pine kraft pulps foilowing treatment with hemicellulolytic enzymes显示文摘 | Clark T A Steward D Bruce M E | 1991 | Appita J1991，44，6： | 1 |
| 14 | Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation显示文摘 | Dinger M E Amaral P P Mercer T R Pang K C Bruce S J Gardiner B B | 2008 | Genome Res2008，18，： | 1 |
| 15 | The impact of depressive symptomatology on physical disability:MacArthur Studies of Successful Aging 显示文摘 | BRUCE M L SEEMAN T E MERRILL S S | 1994 | Am J Public Health1994，84，： | 1 |
| 16 | Improved bleachability of radiata pine kraft pulps following treatment with hemicelluloytic enzymes显示文摘 | Clark T A Steward D Bruce M E | 1991 | Appita1991，44，6： | 1 |
| 17 | Development of a pheromone trap monitoring system for orange wheat blossom midge, Sitodiplosis mosellana, in the UK显示文摘 | Bruce T Hooper A M Ireland L | 2007 | Pest Management Science2007，63，： | 1 |
| 18 | Behavioural responses of the maize weevil, Sitoptn'lus zearnais to host (stored-grain) and non- host plant volatiles显示文摘 | Ukeh D A Birkett M A Bruce T J | 2010 | Pest Management Science2010，66，1： | 1 |
| 19 | Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade;implication for Alzheimer's disease intervention显示文摘 | Zhao LX Bruce T Takashi M | 2004 | J Neurosci2004，24，11： | 1 |
| 20 | Progressive deformation partitioning and deformation history: Evidence from millipede structures显示文摘 | Bell T H M D Bruce | 2007 | Journal of Structural Geology2007，25，1： | 1 |
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