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| 1 | Environmental responsibilities of livestock feeding using trace mineral supplements显示文摘Trace elements are essential dietary components for livestock species. However, they also exhibit a strong toxic potential. Therefore, their fluxes through the animal organism are tightly regulated by a complex molecular machinery that controls the rate of absorption from the gut lumen as well as the amount of excretion via faeces, urine and products(e.g., milk) in order to maintain an internal equilibrium. When supplemented in doses above the gross requirement trace elements accumulate in urine and faeces and, hence, manure. Thereby, trace element emissions represent a potential threat to the environment. This fact is of particular importance in regard to the widely distributed feeding practice of pharmacological zinc and copper doses for the purpose of performance enhancement. Adverse environmental effects have been described, like impairment of plant production, accumulation in edible animal products and the water supply chain as well as the correlation between increased trace element loads and antimicrobial resistance. In the light of discussions about reducing the allowed upper limits for trace element loads in feed and manure from livestock production in the European Union excessive dosing needs to be critically reconsidered. Moreover, the precision in trace element feeding has to be increased in order to avoid unnecessary supplementation and, thereby, heavy metal emissions from livestock production. | Daniel Brugger Wilhelm M. Windisch | 2015 | Animal Nutrition2015，，3： | 7 |
| 2 | 一种基于厚膜工艺的高集成度FAIMS迁移管的研制显示文摘基于厚膜工艺,研制了一种集成有进样接口、气路接口、温控元件和离子源固定装置等外围功能模块的高集成度FAIMS迁移管,阐述了其结构特征和制作方法。为验证其性能,搭建了相应的FAIMS外围检测平台,以丙酮和甲苯为样品进行实验,得到了它们的FAIMS谱图,并与基于MEMS工艺的非集成FAIMS迁移管所测得的丙酮和甲苯的谱图比较,证明了高集成度迁移管在功耗、漏电流、气密性、灵敏度、分辨率和稳定性等方面的优异性能,说明高集成度迁移管适合作为小型化FAIMS独立检测系统的核心器件。 | 赵聪 陈池来 陈然 王焕钦 王电令 刘友江 高钧 尤晖 孔德义 Juergen Brugger | 2012 | 分析仪器2012，，2： | 6 |
| 3 | 高场不对称波形离子迁移谱关键测控模块研究显示文摘研究了高场不对称波形离子迁移谱(high-field asymmetric waveform ion mobility spectrometer,FAIMS)两个关键测控模块:波形不对称高压产生模块和微弱电流检测模块的设计。通过采用反激升压原理,设计了一种电压幅度在线可调的波形不对称高压产生电路模块,其输出电压峰峰值达1 800 V,频率达1 MHz;微弱电流检测采用超高电阻反馈式I-V转换电路,并对失调电压进行补偿,同时结合PCB割板处理及包裹屏蔽等抗干扰措施,使得微弱电流模块的检测下限优于0.1 pA。最后,通过对比实验研究了不同波形不对称高压与分离效果关系,并以苯为样品对系统的检测下限进行了研究,结果表明采用上述测控模块的FAIMS检测下限达1×10-9。 | 刘友江 王焕钦 陈然 孔德义 陈池来 Juergen Brugger | 2012 | 仪器仪表学报2012，33，9： | 4 |
| 4 | 基于FAIMS谱图峰位置的离子迁移率非线性函数解析显示文摘离子迁移率的非线性函数反映了物质本身的微观碰撞特性,是FAIMS技术实现离子分离检测的基础。现有的离子迁移率非线性函数求解方法多是近似求解,存在较大误差。该工作提出了一种基于半正弦分离电压和FAIMS谱图峰位置下的严格求解方法,推导出严格的二阶、四阶系数求解方程。利用自制的高场不对称波形离子迁移谱仪分别对乙醇、间二甲苯和正丁醇三种典型的醇和苯类物质进行检测,获取了三种物质的FAIMS谱图,通过谱图峰位置获得了不同分离电压值下的补偿电压,利用最小二乘法求出三种离子非线性函数二阶、四阶系数。拟合后的均方误差表明FAIMS非线性函数严格求解的方法,明显优于现有的求解方法。有助于提高FAIMS检测分辨率,进而有助于建立更加准确的FAIMS图谱,实现FAIMS对检测物质的精准识别。 | 王电令 陈池来 赵聪 高钧 孔德义 尤晖 Juergen Brugger | 2012 | 光谱学与光谱分析2012，32，8： | 4 |
| 5 | Strategies and challenges to increase the precision in feeding zinc to monogastric livestock显示文摘Practical diets for monogastric livestock must be supplemented with zinc(Zn) due to their high contents of antagonistic substances like phytates. Current feeding recommendations include quite generous safety margins because of uncertainties regarding the gross Zn requirements under varying rearing conditions.Furthermore, the use of pharmacological Zn doses to stabilise animal performance and wellbeing is widespread. Taken together, modern diets for pigs and poultry contain considerably more Zn than necessary to meet animal requirements, which is associated with concerns related to the environment as well as animal and consumer safety. Therefore, European authorities most recently reduced the allowed upper limits for Zn in complete feed. To maintain animal productivity and wellbeing while reducing the Zn load in complete feed, all measures that stabilize feed Zn bioavailability must be applied. Most importantly, reliable information on the gross Zn requirement under practical conditions must be provided, considering the bioavailability of native or supplemented feed Zn, antagonisms with dietary factors as well as the physiological status of the animal. | Daniel Brugger Wilhelm M.Windisch | 2017 | Animal Nutrition2017，，2： | 2 |
| 6 | Inhomogeneous distribution of REE in scheelite and dynamics of Archaean hydrothermal systems (Mt. Charlotte and Drysdale gold deposits, Western Australia)显示文摘 | Jo?l Brugger Yann Lahaye Sylvie Costa David Lambert Roger Bateman | 2000 | Contributions to Mineralogy and Petrology2000，，3： | 2 |
| 7 | Mechanism and kinetics of hydrothermal replacement of magnetite by hematite显示文摘The replacement of magnetite by hematite was studied through a series of experiments under mild hydrothermal conditions(140 -220℃, vapour saturated pressures) to quantify the kinetics of the transformation and the relative effects of redox and non-redox processes on the transformation. The results indicate that oxygen is not an essential factor in the replacement reaction of magnetite by hematite, but the addition of excess oxidant does trigger the oxidation reaction, and increases the kinetics of the transformation. However, even under high O_2(aq) environments, some of the replacement still occurred via Fe^(2+) leaching from magnetite. The kinetics of the replacement reaction depends upon temperature and solution parameters such as pH and the concentrations of ligands, all of which are factors that control the solubility of magnetite and affect the transport of Fe^(2+) (and the oxidant) to and from the reaction front. Reaction rates are fast at ~200℃, and in nature transport properties of Fe and,in the case of the redox-controlled replacement, the oxidant will be the rate-limiting control on the reaction progress. Using an Avrami treatment of the kinetic data and the Arrhenius equation, the activation energy for the transformation under non-redox conditions was calculated to be 26 ± 6 kJ mol^(-1).This value is in agreement with the reported activation energy for the dissolution of magnetite, which is the rate-limiting process for the transformation under non-redox conditions. | Jing Zhao Joel Brugger Allan Pring | 2019 | Geoscience Frontiers2019，10，1： | 2 |
| 8 | Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model显示文摘Early weaning induces intestinal injury,leading to a series of long-term symptoms such as inflammation,malabsorption and diarrhea.In this study,we hypothesized that microbes and theirmetabolitesmodulate the host's inflammatory response to early weaning stress in a goatmodel.A total of 18 female Tibetan goat kids(n?9)wereweaned fromtheirmothers at 28 d(D28)and 60 d(D60)postpartum.D60 and D28 groupswere fed the same solid diet ad libitum fromweaning to 75 d of age.The colonic epithelium was subject to RNAsequencing,the caecal digesta metabolomics were assessed by liquid chromatographyetandem mass spectrometry(LC-MS/MS),and the caecal microbiota composition was analysed by 16S ribosomal RNA gene sequencing.We foundthatearlyweaningsubstantially increased the colonic pro-apoptotic gene expressionof B-cell lymphoma associated X(Bax),caspase-9,and caspase-3,and decreased the expression of zonula occludens-1(ZO-1)and claudin-1(P<0.01).In addition,a significant Bacteroides acidifaciens enrichmentwas observed in the hindgut of early-weaned goats(P<0.01),which negatively correlated with lysophosphatidylcholine products.Similarly,the chemokine signaling,IL-17 signaling,and peroxisome proliferatorsactivated receptor(PPAR)signaling pathways were upregulated in the colonic mucosa of the early-weaned goats.By applying caecal microbiota transplantation from goats to defaunated C57/6J mice,we confirmed that caecalmicrobiota of D28 goat kids increased the relative abundance of B.acidifaciens and significantly upregulated the genes of Bax,G proteinecoupled receptor(GPR)109A,GPR 43,fatty acid binding protein 6,nuclear receptor subfamily 1 group H member 3,angiotensin converting enzyme 2,and IL-6 expression(P<0.05),and decreased ZO-1,and claudin-1 protein expression in the mice jejunum and colon(P<0.001).These results proposed that the hindgut microbiota andmetabolites mediate the barrier functionweakening duringearlyweaning,and the relative abundance of B.acidifacienswas negatively correlatedwiththe hindgut barrier gene expression.This studydemonstrateshowweaningstress canaffectkeyhostemicrobe interaction regulators in the hindgut,in a lysophosphatidylcholine dependent and independent manner.Furthermore,based on our mice data,these results are transferable to other mammal species. | Ke Zhang Yangbin Xu Yuxin Yang Mengmeng Guo Ting Zhang Bo Zong Shuhong Huang Langda Suo Baohua Ma Xiaolong Wang Yujiang Wu Daniel Brugger Yulin Chen | 2022 | Animal Nutrition2022，，3： | 2 |
| 9 | 紫硫镍矿交代镍黄铁矿的水热反应机理及动力学显示文摘本工作首次在实验室条件下对浅生区紫硫镍矿(Ni,Fe)3S4交代镍黄铁矿(Ni,Fe)9S8水热反应的机理及动力学进行了研究。起始反应矿物采用高纯自然镍黄铁矿,合成纯镍黄铁矿或合成镍黄铁矿-磁黄铁矿集合体。反应pH值采用0.2M醋酸-醋酸纳缓冲溶液控制在3~5的范围内。反应进程由X-射线衍射物相定量分析及扫描电镜观察进行跟踪。结果表明,当反应温度恒定在80℃时,交代20(4)%的镍黄铁矿需792h。相同条件下加入少量H2S可将反应速率提高一倍。当反应在125℃饱和蒸汽压水热环境下进行时,完全交代纯镍黄铁矿需约168h。此过程由于磁黄铁矿的存在而被催化,交代集合体中的镍黄铁矿仅需68h,进一步反应磁黄铁矿被交代成白铁矿。磁黄铁矿的催化作用可能源于溶解产生的微裂纹加速了流体的传质过程。当反应温度升高至145℃时,速率反而下降,不遵循Arrhenius经验规律。动力学分析得80℃速率常数介于5.8×10-8~3.0×10-7/s之间,125℃及145℃速率常数分别介于2.8×10-6~2.08×10-5/s及1×10-6~5.1×10-6/s之间,远高于同温度下固相扩散反应的速率常数,表明该反应在地质时标上为一快速反应。此外,用背散射电子显微技术对矿物表面形貌进行了分析,发现交代产物紫硫镍矿具有颗粒细小及存在微裂纹等特征,与自然界浅生矿床中的紫硫镍矿非常相似;电镜实验还表明该交代作用是一个典型的耦合溶解-再沉淀反应。其耦合机制的驱动力可能与反应界面处微空隙对流体饱和度的控制有关。 | 夏方 陈国荣 Allan PRING Joёl BRUGGER Yung NGOTHAI Brain O'NEILL Chris COLBY Christophe TENAILLEAU 王海鹏 杨云霞 | 2007 | 地质学报2007，81，10： | 2 |
| 10 | EGFR-TKI resistant non-small cell lung cancer ( NSCLC ) : new developments and implications for future treatment 显示文摘 | Brugger Wolfram Michael T | 2012 | Lung Cancer2012，77，1： | 1 |
| 11 | Prenatal ultrasound and fetal MRI: The comparative value of each modality in prenatal diagnosis显示文摘 | Denise Pugash Peter C. Brugger Dieter Bettelheim Daniela Prayer | 2008 | European Journal of Radiology2008，，2： | 1 |
| 12 | Boron neutron capture therapy of brain tumors:Past history,current status,and future potential显示文摘 | BARTH R F SOLOWAY A H BRUGGER R M | 1996 | Cancer Invest1996，14，6： | 1 |
| 13 | Felal MRI of the urina ry system显示文摘 | Hormann M Brugger PC Balassy C | 2006 | Eur J Radiol2006，57，2： | 1 |
| 14 | Pattern and severity of injury in avalanche victims 显示文摘 | Hohlrieder M Brugger H Schubert H M | 2007 | High Alt Med Biol2007，，1： | 1 |
| 15 | Diffusion-weighted MR imaging of the normal fetal lung显示文摘 | Balassy C Kasprian G Brugger P C | 2008 | Eur Radiol2008，18，4： | 1 |
| 16 | Development of gastroschisis as seen by magnetic resonance imaging 显示文摘 | Brugger PC & Prayer D | 2011 | Ultrasound Obstet Gynecol2011，37，： | 1 |
| 17 | In utero tractography of fetal white matter development 显示文摘 | Kasprian G Brugger PC Weber M | 2008 | Neuroimage2008，43，2： | 1 |
| 18 | Proton magnetic reso- nance spectroscopy and illness stage in sehizophrenia--a systematic review and meta-analysis 显示文摘 | Brugger S Davis JM Leucht S | 2011 | Biol Psychiatry2011，69，5： | 1 |
| 19 | High-resolution 1D moire s as counterfeit security features显示文摘A moireis an interference pattern that appears when two different periodic structures are overlaid.The image created is extremely sensitive to small variations in the original layers and is thus very interesting for anti-counterfeit protection.We present a microfabricated 1D moire enabling complex high-resolution patterns as a significantly improved security feature that cannot be reproduced using standard printing methods.Furthermore,we demonstrate,theoretically and experimentally,that a microscopic deviation from the original design results in a macroscopic variation in the moire that is clearly visible to the naked eye.The record resolution achieved in the elements fabricated and the increased design freedom,make these high-resolution moires excellent candidates for a variety of visually appealing security applications. | Victor J Cadarso Sylvain Chosson Katrin Sidler Roger D Hersch Jurgen Brugger | 2013 | Light(Science & Applications)2013，2，1： | 1 |
| 20 | An experimental studyof copper(I) -chloride and copper(I) -acetate eomplexing in hydrothermal solutions between 50℃ and 250 ℃ and vapor-saturated pressure 显示文摘 | Liu W McPhail D C Brugger J | 2001 | Geochim Cosmochim Acta2001，65，： | 1 |
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