|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Nonlinear flow and heat transfer dynamics of impinging jets onto slightly-curved surfaces显示文摘 | Haydar E Bulent Y Nevin C | 2007 | Applied Thermal Engineering2007，27，1415： | 1 |
| 3 | Effects of nitrogen fertilizer on yield quality and nutrient content in broccoli显示文摘 | Funda Y Safak C Bulent Y | 2008 | Journal of Plant Nutrition2008，31，7： | 1 |
| 4 | A new saving-based ant algorithm for the vehicle routing prohlem with Simultaneous pickup and delivery 显示文摘 | BULENT C | 2010 | Expert Systems with Applications2010，37，10： | 1 |
| 5 | Drying of seeds in a superheated steam vacuum fluidized bed显示文摘 | BULENT K ADAN C V JORGE W C | 2006 | Journal of Food Engineering2006，75，： | 1 |
| 6 | Photoelastic stress analysis of various retention mechanisms on 3-implant-retained mandibular overdentures显示文摘 | Gozde C Bulent U | 2007 | J Prosthet Dent2007，97，4： | 1 |
| 7 | Photoelastic stress analysis of various retention mechanisms on 3 - implant -retained mandibular overdentures 显示文摘 | Gozde C Bulent U | 2007 | J Prosthet Dent2007，97，4： | 1 |
| 8 | Revisiting firm characteristics,strategy,and export performance relationship:a survey of the literature and an investigation of New Zealand small manufacturing firms显示文摘 | DAVID L D BULENT M MYERS C P | 2000 | Industrial Marketing Management2000，29，： | 1 |
| 9 | Landfill leachate management in Istaabul: applications and alternatives 显示文摘 | BARIS C BULENT M BULENT I | 2005 | Chemo- sphere2005，59，： | 1 |
| 10 | Effect of nasal continuous positive airway pressure in uncontrolled nocturnal asthmatic patients with obstructive sleep apnea syndrome显示文摘 | Tansu UC Bulent C Selma FG | 2005 | Respir Med2005，99，5： | 1 |
| 11 | Neuroprotective effects of uridine in a rat model of neonatal hypoxic–ischemic encephalopathy显示文摘 | Mehmet C Zehra M Bulent G | 2013 | Neurosci Lett2013，542，10： | 1 |
| 12 | Spatio-temporal transform based video hashing显示文摘 | C Baris S Bulent N Memon | 2006 | IEEE Transactions on Multimedia2006，8，6： | 1 |
| 13 | Effects of high free ammonia concentrations on the performances of anaerobic bioreactors显示文摘 | Baris C Bulent M Bulent I | 2005 | Process Biochemistry2005，40，34： | 1 |
| 14 | Urinary IL-18: a marker of contrast-induced nephropathy following percutaneous coronary intervention 显示文摘 | BULENT GUL C B GULLULU M ORAL B | 2009 | Clin Biochem2009，41，7： | 1 |
| 15 | The effect of repeated firings on the color of an all-ceramic system with two different veneering porcelain shades显示文摘 | Gozde C Bulent U Aslihan U | 2008 | J Prosthet Dent2008，99，3： | 1 |
| 16 | The implications of sociali- zation and integration in supply chain management 显示文摘 | Paul D C Bulent M | 2006 | Journal of Operations Manage- ment2006，24，5： | 1 |
| 17 | Loading and distribution ol a model small molecule drugin poly(N-isopropylacrylamide) brushes: A neutron reflectometry and AFM study显示文摘 | Lindsay C C E Ben X J Bulent A | 2013 | Langmuir2013，29，10： | 1 |
| 18 | Photoelastic stress analysis of various retention mechanisms on 3-implant-retained mandibular overdentures显示文摘 | Gozde C Bulent U | | 0，，04： | 1 |
| 19 | Prevention of etomidate-related myoclonus in anesthetic induction by pretreatment with magnesium显示文摘 | Bulent U Dilek C Birgul Y | 2011 | J Res Med Sci2011，16，11： | 1 |
| 20 | Strategic Level Three -stage Production Distribution Planning 显示文摘 | Y Pinar C Bulent | 2005 | Computers and Industrial Engineering2005，48，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员