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| 1 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | The reactions between Ca-based solids and gases representative of those found in a fluidized-bed incinerator显示文摘 | LAWRENCE A D BU J | 2000 | Chemical Engineering Science2000，55，24： | 2 |
| 4 | Vehicle axle loads identification using finite element method 显示文摘 | Law S S Bu J Q Zhu X Q Chan S L | 2004 | Journal of Engineering Structures2004，26，： | 1 |
| 5 | Raman shifts in Si nanocrystals显示文摘 | ZI J BU SCHER H FALTER C | 1996 | Applied Physics Letters1996，69，2： | 1 |
| 6 | CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy 显示文摘 | Passini MA Bu J Roskelley EM | 2010 | J Clin Invest2010，120，4： | 1 |
| 7 | CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscu- lar atrophy显示文摘 | Passini MA Bu J Roskelley EM | 2010 | J Clin Invest2010，120，4： | 1 |
| 8 | Synergism in binary mixtures of surfactants(Ⅳ):Effectiveness of surface tension reduction显示文摘 | BU Yao-zhu ROSEN M J | 1984 | J Colloid Interface Sci1984，99，2： | 1 |
| 9 | Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4 显示文摘 | Yang G R Yuan S Y Fu H J Wan G Zhu L X Bu X L | 2010 | Diabetes Care2010，33，： | 1 |
| 10 | Pancreaticojejunal bridge-anastomosis:a novel option for surgeon to preserve pancreatic body and tail in urgent reoperation for intra-abdominal massive hemorrhage after pancreaticoduodenectomy显示文摘 | Xu J Dai X Bu X | | 0，，10： | 1 |
| 11 | Opinion word expansion and target extraction through double propagation显示文摘 | G Qiu B Liu J Bu C Chen | 2011 | Computational Linguistics2011，37，1： | 1 |
| 12 | A note on computational formulas for the Drazin inverse of certain block matrices 显示文摘 | Bu C J Feng C C Dong P F | 2012 | Appl Math Comput2012，38，1： | 1 |
| 13 | Correction of simple contrast loss in color images 显示文摘 | Oakley J P Bu H | 2007 | IEEE Transactions on Image Processing2007，16，2： | 1 |
| 14 | Thedirect release of nitric oxide by Gypenoside derived from theHerb Gynostemma pentaphyllum显示文摘 | Miles A Tanner Xin Bu J Alan Steimle P R Myers | 1999 | Biology and Chemis-try1999，3，5： | 1 |
| 15 | Co-delivery of IL-2 or liposomes augment the responses of mice to a DNA vaccine for pseudorabies virus IE180显示文摘 | J Bu Y Song G Rompato D.J Burgess A.E Garmendia | 2002 | Comparative Immunology Microbiology and Infectious Diseases2002，，3： | 1 |
| 16 | In vitro culture and characterization of a mammary epithelial cell line from Chinese Holstein dairy cow显示文摘 | Hu H Wang J Bu D | 2009 | PLOS ONE2009，4，11： | 1 |
| 17 | Representations for the Drazin inverses of the sum of two matrices and some block matrices显示文摘 | Bu C J Feng C C Bai S Y | 2012 | Appl Math Comput2012，218，10： | 1 |
| 18 | Age-related changes in cal- bindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortex 显示文摘 | Bu J Sathyendra V Nagykery N | 2003 | Exp Neurol2003，182，： | 1 |
| 19 | Distributed access control with priva-cy support in wireless sensor networks 显示文摘 | HE D BU J ZHU S | 2011 | IEEE Transactions onWireless Communications2011，10，10： | 1 |
| 20 | Emodin potentiates the antitu- mor effects of gemcitabine in PANC-1 pancreatic cancer xeno- graft model in vivo via inhibition of inhibitors of apoptosis显示文摘 | GUO HC BU HQ LUO J | 2012 | Int J Oncol2012，40，： | 1 |
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