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| 1 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 2 | POLAR project: a numerical study to optimize the target design显示文摘 | C Busschaert é Falize B Loupias C Michaut A Ravasio A Pelka R Yurchak M Koenig | 2013 | New Journal of Physics2013，，3： | 1 |
| 3 | Prevalence and challenge tests of Listeria monocytogenes in Belgian produced and retailed mayonnaise-based deli-salads,cooked meat products and smoked fish between2005and2007显示文摘 | UYTTENDAELE M BUSSCHAERT P VALERO A | 2009 | International Journal of Food Microbiology2009，133，12： | 1 |
| 4 | Hormonal responses in athletes:the use of a two bout exercise protocol to detect subtle differences in (over)training status显示文摘 | MEEUSEN R PIACENTINI M F BUSSCHAERT B | 2004 | Eur J Appl Physiol2004，91，2： | 1 |
| 5 | Estimating distributions out of qualitative and(semi)quantitative microbiological contamination data for use in risk assessment显示文摘 | Busschaert P Geeraerd A H Uyttendaele M | | 0，，03： | 1 |
| 6 | Anion receptor chemistry: highlights from 2011 and2012 显示文摘 | GALE P A BUSSCHAERT N HAYNES C J | 2014 | ChemSocRev2014，43，： | 1 |
| 7 | Estimating distributions out of qualitative and (semi) quantitative microbiological contamination data for use in risk assessment显示文摘 | BUSSCHAERT P GEERAERD A UYTTENDAELE M | 2010 | International Journal of Food Microbiology2010，138，3： | 1 |
| 8 | Hormonal responses in athletes:the use of a two bout exercise protocol to detect subtle differences in (over) training status显示文摘 | Meeusen R Piacentini MF Busschaert B | 2004 | Ear J Appl Physiol2004，91，23： | 1 |
| 9 | Bacterial communitydynamics during cold storage of minced meat packaged undermodified atmosphere and supplemented with different preservatives显示文摘 | STOOPS J RUYTERS S BUSSCHAERT P | 2015 | Food Microbiology2015，48，： | 1 |
| 10 | Applications of supramolecular anion recognition显示文摘 | BUSSCHAERT N CALTAGIRONE C VAN ROSSOM W | 2015 | Chem Rev2015，115，： | 1 |
| 11 | Hormonal responses in athletes: the use of a two bout exercise protocol to detect subtle differences in (over)training status显示文摘 | R. Meeusen M. F. Piacentini B. Busschaert L. Buyse G. Schutter J. Stray-Gundersen | 2004 | European Journal of Applied Physiology (-)2004，，2： | 1 |
| 12 | Squaramides as potent transmembrane anion transporters显示文摘 | Busschaert N Kirby I L Young S | 2012 | Angewandte Chemic International Edition2012，51，18： | 1 |
| 13 | Gross N transforma-tion rates and net N mineralisation rates related to the C and N contents ofsoil organic matter fractions in grassland soils of different age显示文摘 | ACCOE F?BOECKX P?BUSSCHAERT J | 2004 | Soil Kologyand Hochemistry?2004，36，12： | 1 |
| 14 | Anion receptor chemistry, Highlights from 2011 and 2012 显示文摘 | GALE P A BUSSCHAERT N HAYNES C J | 2014 | Chern Soc Rev2014，43，： | 1 |
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