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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | Cells Expressing the NG2 Antigen Contact Nodes of Ranvier in Adult CNS White Matter 显示文摘 | BUTT AM DUNCAN A HORNBY MF | 1999 | Gila(S0894-4191)1999，26，1： | 1 |
| 3 | Solid pseudopapillary tumors of the pancreas:clinical features,surgical outcomes,and long-term survival in 45 consecutive patients from a single center显示文摘 | Butte JM Brennan MF Gonen M | | 0，，： | 1 |
| 4 | Epidemiology of spinal cord injuries in the 2005 Pakistan earthquake 显示文摘 | RATHORE MF RASHID P BUTT AW | 2007 | Spinal Cord2007，45，10： | 1 |
| 5 | Management of unstable thoracolumbar spinal injuries by posterior short segment spinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，2： | 1 |
| 6 | Management of unstablethoracolum-bar spinal injuries by posterior short segmentspinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，2： | 1 |
| 7 | Management of unstable thoracolum-bar spinal injuries by posterior short segment spinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | IntOrthop2007，31，2： | 1 |
| 8 | In situ instrumented posterolateral fusion without decompression in symptomatic low-grade isthmic spondylolisthesis in adults显示文摘 | Butt MF Dhar SA Hakeem I | 2008 | Int Orthop2008，32，5： | 1 |
| 9 | Management of unsta- ble thoracolumbar spinal injuries by posterior short seg- ment spinal fixation 显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，2： | 1 |
| 10 | Management of un- stable thoracolumbar spinal injuries by posterior short segment spinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，2： | 1 |
| 11 | Management of unsta- blethoraeolumbar spinal injuries by posterior short segment spinal fixation显示文摘 | Butt MF Farooq M Mir B | 2007 | IntOrthop2007，31，2： | 1 |
| 12 | Management of unstable thoracolum- bar spinal injuries by posterior short segment spinal fixation 显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Or- thop2007，31，2： | 1 |
| 13 | Management of unstable thoracolunbar spinal injuries by posterior short segment spinal fixation 显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，2： | 1 |
| 14 | Delayed fixation of displaced femoral neck fractures in younger adults 显示文摘 | Butt MF Dhar SA Gani NU | 2008 | Injury2008，39，2： | 1 |
| 15 | Management of unstable thoracolum- bar spinal injuries by posterior short segment spinal fixation 显示文摘 | Butt MF Farooq M Mir B | 2007 | Int Orthop2007，31，： | 1 |
| 16 | Management of unstable thoracolumbar spinal injuries by posterior short segment spinal ifxation显示文摘 | Butt MF Farooq M Mir B | | 0，，： | 1 |
| 17 | Clinical features,surgical outcomes,and long-term survival in 45 consecutive patients from a single center显示文摘 | Butte JM Brennan MF Gonen M | 2011 | Journal of Gastrointestinal Surgery2011，15，2： | 1 |
| 18 | Failure of methotrexate and internal iliac balloon catheterization to manage placenta percreta显示文摘 | Butt K Gagnon A Delisle MF | 2002 | Obstetrics & Gynecology2002，99，6： | 1 |
| 19 | Lateral invagina- ting peg(LIP) osteomy for the correction of post-trau- matic eubitus varus deformity显示文摘 | Butt MF Dhar SA Farooq M | 2009 | J Pediatr Orthop B2009，18，5： | 1 |
| 20 | Management of nustable tho- racolumbar spinal injuries by posterior short segment spinal fixation显示文摘 | Butt MF Farooq M Mir B et d | 2007 | Int Orthop2007，31，2： | 1 |
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