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| 1 | Role of frailty and sarcopenia in predicting outcomes among patients undergoing gastrointestinal surgery显示文摘According to the United States census bureau 20% of Americans will be older than 65 years in 2030 and half of them will need an operation- equating to about 36 million older surgical patients. Older adults are prone to complications during gastrointestinal cancer treatment and therefore may need to undergo special pretreatment assessments that incorporate frailty and sarcopenia assessments. A focused, structured literature review on Pub Med and Google Scholar was performed to identify primary research articles, review articles, as well as practice guidelines on frailty and sarcopenia among patients undergoing gastrointestinal surgery. The initial search identified 450 articles; after eliminating duplicates, reports that did not include surgical patients, case series, as well as case reports, 42 publications on the impact of frailty and/or sarcopenia on outcome of patients undergoing gastrointestinal surgery were included. Frailty is defined as a clinically recognizable state of increased vulnerability to physiologic stressors resulting from aging. Frailty is associated with a decline in physiologic reserve and function across multiple physiologic systems. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Unlike cachexia, which is typically associated with weight loss due to chemotherapy or a general malignancy-related cachexia syndrome, sarcopenia relates to muscle mass rather than simply weight. As such, while weight reflects nutritional status, sarcopenia- the loss of muscle mass- is a more accurate and quantitative global marker of frailty. While chronologic age is an important element in assessing a patient's peri-operative risk, physiologic age is a more important determinant of outcomes. Geriatric assessment tools are important components of the preoperative work-up and can help identify patients who suffer from frailty. Such data are important, as frailty and sarcopenia have repeatedly been demonstrated among the strongest predictors of both short- and longterm outcome following complicated surgical procedures such as esophageal, gastric, colorectal, and hepatopancreatico-biliary resections. | doris wagner mara mcadams demarco neda amini stefan buttner dorry segev faiz gani timothy m pawlik | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 8 |
| 2 | orf virus encodes a functional dUTPase gene显示文摘 | Cottone R Buttner M McInnes C | 2002 | J Gener Virol2002，83，5： | 1 |
| 3 | AFLP markers tightly linked to the sex locus in Asparagus officinalisL显示文摘 | Reamon Buttner S M Schondelmaier J Jung C | 1998 | Molecular Breeding1998，4，2： | 1 |
| 4 | Secretion of biologically active interferon tau by in vitro-derived bovine trophoblastic tissue显示文摘 | Stojkovic M Wolf E Buttner M | 1995 | Biol Reprod1995，53，： | 1 |
| 5 | Secretion of interferon-tau by bovine embryos in long-term culture: comparison of in vivo derived, in vitro produced, nuclear transfer and demi-embryos 显示文摘 | Stojkovic M Buttner M Zakhartchenko V | 1999 | Anim Reprod Sci1999，55，： | 1 |
| 6 | Monosaccharide transporters in plants: structure, function and physiology显示文摘 | Buttner M Sauer N | 2000 | Biochimica et Biophysica Acta2000，1465，1： | 1 |
| 7 | The monosaccharide transporter (-like) gene family in Arabidopsis显示文摘 | Buttner M | 2007 | Febs Letters2007，581，12： | 1 |
| 8 | High-speed rotational atherectomy before paclitaxel-eluting stent implantation in complex calcified coronary lesions: the randomized ROTAXUS (Rotational Athereetomy Prior to Taxus Stent Treatment for Complex Native Coronary Artery Disease) trial 显示文摘 | Abdel-Wahab M Richardt G Joachim Buttner H | 2013 | JACC Cardiovasc lnterv2013，6，1： | 1 |
| 9 | Mutations abrogating the Rnase activity in glycoprotein E(rns) of the pestivirus classical swine fever virus显示文摘 | Saalmuller A Buttner M | 1999 | J Virol1999，73，10： | 1 |
| 10 | GLUT-1mRNA and protein expression in ovarian borderline tumors and cancer显示文摘 | Rudlowski C Moser M Becker AJ Rath W Buttner R Schroder W | 2004 | Oncology2004，66，5： | 1 |
| 11 | Identification and functional expression of the Arabidopsis thaliana vacuolar glucose transporter 1 and its role in seed germination and flowering 显示文摘 | Aluri S Buttner M | 2007 | PNAS2007，104，7： | 1 |
| 12 | Myosin heavy chain protein and gone expression in the masseter muscle of adult patients with distal or mesial malocclusion显示文摘 | Gedrange T Buttner C Schneider M | 2005 | J Appl Genet2005，46，2： | 1 |
| 13 | Serum levels of neuron-specific enolase and s-100 protein after single tonicclonic seizures 显示文摘 | Buttner T Lack B Jager M | 1999 | J Neurol1999，246，6： | 1 |
| 14 | Arabidopsis thaliana ethylene-responsive element binding protein (AtEBP), an ethylene-inducible, GCC box DNA-binding protein interacts with an ocs dement binding protein 显示文摘 | Buttner M Singh K B | 1997 | Proc Natl Acad Sci USA1997，94，11： | 1 |
| 15 | Bilateral loss of eighth nerve function as the only clinical sign of vertebrobasilar dolichoectasia显示文摘 | BUTTNER U OTT M HELMCHEN C | 1995 | J Vestibular Res:Equilibrium Orientation1995，5，： | 1 |
| 16 | Serum levels of neuronspecific enolase and s-100 protein after single tonic-clonic seizures 显示文摘 | Buttner T Lack B Jager M | 1999 | Neurol1999，246，6： | 1 |
| 17 | Change of mRNA amount of myosin heavy chain in masseter muscle after orthognathic surgery of patients with malocclusion显示文摘 | Gedrange T Buttner C Schneider M | 2006 | J Craniomaxillofac Surg2006，34，2： | 1 |
| 18 | Secretion of interferon-τ by bovine embryos in long-term culture:comparison of in vivo derived,in vitro produced,nuclear transfer and demi-embryos显示文摘 | Stojkovic M Buttner M Zakhartchenko K | 1999 | Anim Reprod Sci1999，55，34： | 1 |
| 19 | Identification of a calicivirus isolate of unknown origin显示文摘 | Oehmig A Buttner M Weiland F | 2003 | J Gen Virol2003，84，： | 1 |
| 20 | Myosin heavy chain protein and gene expression in the masseter muscle of adult patients with distal or mesial malocclusion显示文摘 | Gedrange T Buttner C Schneider M | 2005 | J Appl Genet2005，46，2： | 1 |
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