| 2 | 按需服用20mg泮托拉唑可作为轻度胃食管反流病患者的长期治疗手段:ORION试验显示文摘Aims: To compare safety and efficacy of on- demand pantoprazole 20 mg/40 mg versus placebo in the long- term management of patients with mild gastroesophageal reflux disease (GERD) after heartburn relief. Methods: A total of 634 patients with endoscopically confirmed GERD grade 0/I and heartburn were included. During the acute phase, patients were treated with pantoprazole 20 mg once daily for 4 weeks. Those patients relieved from heartburn entered the long- term phase, and were randomly assigned to either treatment group pantoprazole 20 mg, 40 mg or placebo. Over 6 months, patients took study medication on demand (antacids as rescue medication) and discontinued the drug once symptoms abated. Results: After 4 weeks a total of 87.1% /90.0% of patients were free of heartburn (ITT/PP), and entered the subsequent long- term phase. The perceived average daily symptom load (placebo: 3.93, pantoprazole 20 mg: 2.91, pantoprazole 40 mg: 2.71, ITT) and the number of antacid tablets taken (average number, placebo: 0.68, pantoprazole 20 mg: 0.45, pantoprazole 40 mg: 0.33, ITT) were significantly higher in the placebo than in both pantoprazole groups (p < 0.0001), with no statistically significant difference between the two pantoprazole groups. The discontinuation rate due to insufficient control of heartburn was significantly lower in both pantoprazole groups compared to placebo (placebo: 10.9, pantoprazole 20 mg: 2.8, pantoprazole 40 mg: 0.9, ITT). Conclusions: Our findings favor on- demand treatment with pantoprazole 20 mg for the long- term management of heartburn in patients with uncomplicated GERD (grade 0/I) with superiority to placebo. | Scholten T. Dekkers C.P.M. Schü tze K. 尹勇 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，2： | 0 |
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