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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | Influence of a fine glass powder on the durability characteristics of concrete and its comparison to fly ash显示文摘 | SCHWARZ N CAM H NEITHALATH N | 2008 | Cement & Concrete Composites2008，，30： | 1 |
| 3 | KITS acts in cis to promote RNA interference - mediated transcriptional and post - transcriptional silencing 显示文摘 | Noma K Sugiyama T Cam H | 2004 | Nat Genet2004，36，11： | 1 |
| 4 | Intracranial hemorrhage due to vitamin K deficiency after the newborn period显示文摘 | Demiroren K Yavuz H Cam L | 2004 | Pediatr Hematol Oncol2004，21，7： | 1 |
| 5 | Diffusion bonding of γ- TiA1 sheets显示文摘 | Cam G Clemens H Gerling R | 1999 | Intermetallics1999，，7： | 1 |
| 6 | E2F integrates cell cycle progression with DNA repair, replication, and G2/M check2 points显示文摘 | Ren B Cam H Takahashi Y | 2002 | Genes Dev2002，16，2： | 1 |
| 7 | Classification of eight pomegranate juices based on antioxidant capacity measured by four methods显示文摘 | Mustafa Cam Yasar H|s|l Gkhan Durmaz | 2009 | Food Chemistry2009，112，3： | 1 |
| 8 | Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?显示文摘 | Cam M C Brownsey R W McNeil] J H | 2000 | Can J Physiol Pharmacol2000，78，： | 1 |
| 9 | Partial preservation of pancreatic β-cells by vanadium: Evidence for long-term amelioration of diabetes显示文摘 | Cam M C LiW M Mcneill J H | 1997 | Metabolism1997，46，7： | 1 |
| 10 | Postpartum sexual func-tion of women and the effects of early pelvic floor muscleexercises显示文摘 | Citak N Cam C Arslan H | 2010 | Acta Obstet Gynecol Scand2010，89，6： | 1 |
| 11 | Influence of a fine glass powder on the durabihty characteristics of concrete and its comparison to fly ash显示文摘 | Schwarz N Cam H Neithalath N | 2008 | Cement and Concrete Composite2008，30，： | 1 |
| 12 | Emerging roles for E2F:beyond? the G1/S transition and DNA replication 显示文摘 | Cam H Dynlacht B D | 2003 | CancerCell2003，3，4： | 1 |
| 13 | Emerging roles for E2F: beyond the G1/S transition and DNA replication显示文摘 | Cam H Dynlacht BD | 2003 | Cancer Cell2003，3，4： | 1 |
| 14 | What is the Role of Diffusion Weigh Magnetic Resonance Imaging in Evaluation of Thyroid Nodules显示文摘 | Cam O H Tekin M Acar G O | 2014 | Indian J Otolaryngol Head Neck Surg2014，66，3： | 1 |
| 15 | Postpartum sexual function of women and the effects of early pelvic floor musele exercises 显示文摘 | Citak N Cam C Arslan H | 2010 | Acta Obstet Gynecol Scand2010，89，6： | 1 |
| 16 | Mild hypoglycaemic at acks induced by sulphonylureas related to CYP2C9,CYP2C19 and CYP2C8 polymorphisms in routine clinical set ing显示文摘 | Gokalp O Gunes A Cam H | | 0，，12： | 1 |
| 17 | Postpartum sexual function of women and the effects of early pelvic floor muscle exercises显示文摘 | Citak N Cam C Arslan H | 2010 | Acta Obstet Gynecol Scand2010，89，6： | 1 |
| 18 | Postpartum sexual function of women and the effects of early pelvic floor muscle exercises显示文摘 | Citak N Cam C Arslan H | 2010 | Acta Obstet Gynecol Scand2010，89，6： | 1 |
| 19 | E2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints显示文摘 | Cam H Takahashi Y | 2002 | Genes Dev2002，16，2： | 1 |
| 20 | Influence of a fine glass powder on the durability characteristics of concrete and its comparison to fly ash 显示文摘 | Schwarz N Cam H Neithalath N | 2008 | Cem Concr Compos2008，30，48： | 1 |
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