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| 1 | Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine显示文摘Erysiphe necator is the causal agent of powdery mildew(PM),one of the most destructive diseases of grapevine.PM is controlled by sulfur-based and synthetic fungicides,which every year are dispersed into the environment.This is why PM-resistant varieties should become a priority for sustainable grapevine and wine production.PM resistance can be achieved in other crops by knocking out susceptibility S-genes,such as those residing at genetic loci known as MLO(Mildew Locus O).All MLO S-genes of dicots belong to the phylogenetic clade V,including grapevine genes VvMLO7,11 and 13,which are upregulated during PM infection,and VvMLO6,which is not upregulated.Before adopting a gene-editing approach to knockout candidate S-genes,the evidence that loss of function of MLO genes can reduce PM susceptibility is necessary.This paper reports the knockdown through RNA interference of VvMLO6,7,11 and 13.The knockdown of VvMLO6,11 and 13 did not decrease PM severity,whereas the knockdown of VvMLO7 in combination with VvMLO6 and VvMLO11 reduced PM severity up to 77%.The knockdown of VvMLO7 and VvMLO6 seemed to be important for PM resistance,whereas a role for VvMLO11 does not seem likely.Cell wall appositions(papillae)were present in both resistant and susceptible lines in response to PM attack.Thirteen genes involved in defense were less upregulated in infected mlo plants,highlighting the early mlo-dependent disruption of PM invasion. | Stefano Pessina Luisa Lenzi Michele Perazzolli Manuela Campa Lorenza Dalla Costa Simona Urso Giampiero Valè Francesco Salamini Riccardo Velasco Mickael Malnoy | 2016 | Horticulture Research2016，3，1： | 7 |
| 2 | A new interaction between Abi-1 and βPIX involved in PDGF-activated actin cytoskeleton reorganisation显示文摘Members of the Rho family of GTPases are key regulators of the actin cytoskeleton.In particular,activated Rac 1stimulates membrane dorsal ruffle formation in response to platelet-derived growth factor (PDGF).Abl-interactor (Abi)-1 and βPIX,a guanine nucleotide exchange factor for Rac 1,localise at these Rac1-induced actin structures and playimportant roles in the induction of membrane dorsal ruffling in response to PDGF in fibroblasts.Here,we demonstratea novel interaction between Abi-1 and βPIX using the yeast two-hybrid system,in vitro pull-down assays,and in vivoco-immunoprecipitation experiments.In vitro,the C-terminal fragment of ]3PIX interacted with Abi-1,while in vivo theN-terminal fragment of βPIX interacted with Abi-1.The biological function of this interaction was investigated in mousefibroblasts in response to PDGF stimulation.Abi-1 and βPIX co-localised in the cytoplasm and to membrane dorsalruffles after PDGF treatment.We show that the co-expression of Abi-1 and truncated forms of βPIX in mouse fibroblastsblocked PDGF-induced membrane dorsal ruffles.Together,these results show that the interaction between Abi-1 andβPIX is involved in the formation of growth factor-induced membrane dorsal ruffles. | Fanny Campa NikolausMachuy AlexanderKlein ThomasRudel | 2006 | Cell Research2006，16，9： | 3 |
| 3 | Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer显示文摘 | Brandon A. Howard Zhong Zheng Michael J. Campa Michael Z. Wang Anupama Sharma Eric Haura James E. Herndon Michael C. Fitzgerald Gerold Bepler Edward F. Patz | 2004 | Lung Cancer2004，，： | 2 |
| 4 | First Pre‐Functionalised Polymeric Aromatic Framework from Mononitrotetrakis(iodophenyl)methane and its Applications显示文摘 | Ester Verde‐Sesto Mercedes Pintado‐Sierra Avelino Corma Eva M. Maya Jose G. de la Campa Marta Iglesias Felix Sánchez | 2014 | Chem. Eur. J2014，，17： | 2 |
| 5 | Source origin of trace elements in PM from regional background, urban and industrial sites of Spain显示文摘 | X. Querol M. Viana A. Alastuey F. Amato T. Moreno S. Castillo J. Pey J. de la Rosa A. Sánchez de la Campa B. Artí?ano P. Salvador S. García Dos Santos R. Fernández-Patier S. Moreno-Grau L. Negral M.C. Minguillón E. Monfort J.I. Gil A. Inza L.A. Ortega J.M | 2007 | Atmospheric Environment2007，，34： | 2 |
| 6 | PM_(2.5) chemical composition and health risks by inhalation near a chemical complex显示文摘Particulate matter(PM_(2.5))samples were collected in the vicinity of an industrial chemical pole and analysed for organic and elemental carbon(OC and EC),47 trace elements and around 150 organic constituents.On average,OC and EC accounted for 25.2% and 11.4% of the PM_(2.5) mass,respectively.Organic compounds comprised polycyclic aromatic hydrocarbons(PAHs),alkylated PAHs,anhydrosugars,phenolics,aromatic ketones,glycerol derivatives,aliphatic alcohols,sterols,and carboxyl groups,including aromatic,carboxylic and dicarboxylic acids.Enrichment factors>100 were obtained for Pb,Cd,Zn,Cu,Sn,B,Se,Bi,Sb and Mo,showing the contribution of industrial emissions and nearby major roads.Principal component analysis revealed that vehicle,industrial and biomass burning emissions accounted for 66%,11% and 9%,respectively,of the total PM_(2.5)-bound PAHs.Some of the detected organic constituents are likely associated with plasticiser ingredients and thermal stabilisers used in the manufacture of PVC and other plastics in the industrial complex.Photooxidation products of both anthropogenic(e.g.,toluene)and biogenic(e.g.,isoprene and pinenes)precursors were also observed.It was estimated that biomass burning accounted for 13.8%of the PM_(2.5) concentrations and that secondary OC represented 37.6% of the total OC.The lifetime cancer risk from inhalation exposure to PM_(2.5)-bound PAHs was found to be negligible,but it exceeded the threshold of 10−6 for metal(loi)s,mainly due to Cr and As. | Celia Alves Margarita Evtyugina Estela Vicente Ana Vicente Ismael Casotti Rienda Ana Sanchez de la Campa Mario Tome Iola Duarte | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 7 | Exchange Rate Pass - Through into Import Prices显示文摘 | Campa J M Goldberg L S | 2005 | The Review of Economics and Statistics2005，87，： | 1 |
| 8 | Polymorphisms of DNA repair genes and risk of non-small cell lung cancer 显示文摘 | Zienolddiny S Campa D Lind H | 2006 | Carcinogenesis2006，27，： | 1 |
| 9 | Notch activates cell cycle reentry and progres- sion in quiescent cardiomyocytes 显示文摘 | CAMPA V M GUTIERREZ-LANZA R CERIGNOLI F | 2008 | J Cell Biol2008，183，： | 1 |
| 10 | Association of ABCB1/MDRI and OPRM1 gene polymorphisms with morphine pain relief 显示文摘 | Campa D Gioia A Tomei A | 2008 | Clin Pharmacol Ther2008，83，4： | 1 |
| 11 | The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression显示文摘 | Jim6nez-S6nchez L Campa L Auberson YP | 2014 | Neuropsychopharmacology2014，39，11： | 1 |
| 12 | Mortality risk in selenium-deficient HIV-positive children 显示文摘 | Campa A Shor-Posner G Indacochea F | 1999 | J Acquir Immune Defic Syndr Hum Retrovirol1999，20，5： | 1 |
| 13 | Entry by foreign firms in the United States under exchange rate uncertainty显示文摘 | Campa J M | 1993 | Review of Economics and Statistics1993，，75： | 1 |
| 14 | Advances and analytical applications in chemiluminescence coupled to capillary electrophoresis显示文摘 | Francisco J.Lara Ana M.García‐Campa?a Aurelia Ibá?ezVelasco | 2010 | ELECTROPHORESIS2010，，12： | 1 |
| 15 | Early multifocal electroretinogram findings during intravitreal ranibizumab treatment for neovascular age-related macular degeneration显示文摘 | Campa C Hagan R Sahni J N | 2011 | Invest Ophthalmol Vis Sci2011，52，6： | 1 |
| 16 | Design and flight testing evaluation of formation control laws显示文摘 | GU Y SEANOR B CAMPA G | 2006 | IEEE Transactions on Control Systems Technology2006，14，6： | 1 |
| 17 | Structure of the oligomers obtained by enzymatic hydrolysis of the glucomannan produced by the plant Amorphophallus konjac显示文摘 | CESCUTTI P CAMPA C DELBEN F | 2002 | Carbohydrate Research2002，337，： | 1 |
| 18 | Structure of the oligomers obtained by enzymatic hydrolysis of the glucomannan produced by the plant Amorphophallus konjac显示文摘 | Cescutti Paola Campa Cristiana Delben Franco | 2002 | Carbohydrate Research2002，337，24： | 1 |
| 19 | The management of intractable bone pain: a clinician's perspective显示文摘 | Campa JA 3rd Payne R | 1992 | Semin Nucl Med1992，22，1： | 1 |
| 20 | Differentiating agents low-dose chemotherapy in the management of old/poor prognosis patients with acute myeloid leukemia or myelodysplastic syndrome显示文摘 | Ferrero D Campa E Dellacasa C | 2004 | Haematologica2004，89，5： | 1 |
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