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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 3 | Optimization of Conditions for Anthocyanin Hydrolysis from Red Wine Using Response Surface Methodology(RSM)显示文摘 | Carina P Armindo M Catarina M | 2011 | Agric Food Chem2011，59，12： | 1 |
| 4 | Characterization of JP-7 jet fuel degradation by the bacterium nocardioides luteus strain BAFB显示文摘 | CARINA M J CHRIS B | 2002 | J Basic Microbiol2002，42，2： | 1 |
| 5 | Ecological Footprint Analysis as a Tool to Assess Tourism Sustainability显示文摘 | Stefan Go¨ssling Carina Borgstro¨m Hansson Oliver Ho¨rstmeier | 2002 | Ecological Economics2002，，43： | 1 |
| 6 | Water hyacinths as a resource in agriculture and energy production:A literature review显示文摘 | Carina C G Cecilia M P | 2007 | Waste Management2007，27，： | 1 |
| 7 | Insulin--like growth factor-- 1 is a potent neuronal rescue agent after hypoxic -- ischemic injury in fetallambs显示文摘 | Barbara M Johnston E Carina M | 1996 | Clin Invest1996，97，2： | 1 |
| 8 | Exploring the two-gene ratio in breast cancer—independent roles for HOXB13 and IL17BR in prediction of clinical outcome显示文摘 | Piiha-Lotta Jerevall Sara Brommesson Carina Strand Sofia Gruvberger-Saal Per Malmstr?m Bo Nordenskj?ld Sten Wingren Peter S?derkvist M?rten Fern? Olle St?l | 2007 | Breast Cancer Research and Treatment2007，，2： | 1 |
| 9 | Reactive dyes remotion by porous TiO2-chitosan materials显示文摘 | CAROLINA E Z PAULA V M CARINA L | 2008 | Journal of Hazardous materials2008，152，： | 1 |
| 10 | Signaling by CD95 and TNF receptor: not only life and death显示文摘 | David LV | 1999 | Immunology and Cell Bio11999，77，： | 1 |
| 11 | Insulin - like growth factor- 1 is a potent neuronal rescue abent after hypoxic - ischemic injury in fetal lambs显示文摘 | Barbara M Johnston E Carina Mallard Chris Williams | 1996 | J Clin Invest1996，29，7： | 1 |
| 12 | Clinical Phase I study with an Insulin-like Growth Factor-1 Receptor Inhibitor: Experiences in patients with squamous non-small cell lung carcinoma显示文摘 | Simon Ekman Jan-Erik Fr? din Johan Harmenberg Antonina Bergman ? sa Hedlund Pia Dahg Carina Alvfors Birgitta St? hl Stefan Bergstr? m Michael Bergqvist | 2011 | Acta Oncologica2011，，3： | 1 |
| 13 | The recent evolution of pentachlorophenol(PCP) -4-monooxygenaso (PcpB) and associated pathways for bacterial degradation of PCP显示文摘 | Carina M J Janice L S | 2007 | Biodegradation2007，18，： | 1 |
| 14 | Temporal variability of 210pb fluxes and bioturbation in shelf sediments beneath the high primary production area off Concepcion, central-southern Chile(36°S) 显示文摘 | PRAXEDES M JAVIER S CARINA L | 2007 | Progress in Oceanography2007，75，： | 1 |
| 15 | Extracellular NAD + induces a rise in [Ca 2+ ] i in activated human monocytes via engagement of P2Y 1 and P2Y 11 receptors显示文摘 | Carina Klein Anja Grahnert Aliaa Abdelrahman Christa E. Müller Sunna Hauschildt | 2009 | Cell Calcium2009，，4： | 1 |
| 16 | Models of white matter injury: comparison of infections, hypoxic-ischemic, and excitotoxic insults 显示文摘 | Henrik H Donald P Carina M | 2002 | Mental Ret2002，8，： | 1 |
| 17 | Influ- ence of microwave and steam heating on lipase activity andmicrostructure of rapeseed ( Brazsica napus ) 显示文摘 | CARINA T P ANNA C M LEOPOLD M M T | 1996 | J Agric Food Chem1996，44，： | 1 |
| 18 | Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy显示文摘 | Mark A Wallet Carina A Rodriguez Li Yin Sara Saporta Sasawan Chinratanapisit Wei Hou John W Sleasman Maureen M Goodenow | 2010 | AIDS2010，，： | 1 |
| 19 | Is heparin treatmentthe optimal management for cerebral venous thrombosis:Effectof abciximab, recombinant tissue plasminogen activator, andenoxaparin in experimentally induced superior sagittal sinusthrombosis显示文摘 | Carina R Katharina M Matthias H | 2005 | Stroke2005，36，： | 1 |
| 20 | Effects of electromagnetic field emitted by cellular phones on the EEG during a memory task显示文摘 | Christina M. Krause Lauri Sillanm?ki Mika Koivisto Anna H?ggqvist Carina Saarela Antti Revonsuo Matti Laine Heikki H?m?l?inen | 2000 | NeuroReport2000，，4： | 1 |
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