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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Fusion product planning: A market offering perspeetive显示文摘 | Chen Y Carrillo J E Vakharia A J | 2010 | Decision Sciences2010，41，2： | 1 |
| 3 | Posttranscrip- tional regulation of the t2-subunit of cardiac L-type Caz+ channels by MicroRNAs during long-term exposure to isoproterenol in rats显示文摘 | Carrillo ED Escobar Y Gonzdlez G | 2011 | J Cardiovasc Pharmacol2011，58，5： | 1 |
| 4 | Effect of local anesthesia on trabeculectomy success显示文摘 | Geffen N Carrillo MM Jin Y | | 0，，08： | 1 |
| 5 | Soil Fauna Alter the Effects of Litter Composition on Nitrogen Cycling in a Mineral Soil显示文摘 | CARRILLO Y BALL B A BRADFORD M A | 2011 | Soil Biology and Biochemistry2011，43，7： | 1 |
| 6 | Rhizosphere priming:a nutrient perspective显示文摘 | Dijkstra FA Carrillo Y Pendall E Pendall E Morgan JA | | 0，，： | 1 |
| 7 | Whole brain and localized magnetization transfer measurements are associated with cognitive impairment in patients infected with human immunodeficiency virus显示文摘 | Wu Y Storey P Carrillo A | 2008 | AJNR2008，29，1： | 1 |
| 8 | Resource-island soils and the survival of the giant cactus, cardon, of Baja California Sur显示文摘 | CARRILLO G A BASHAN Y BETHLENFALVAY G J | 2000 | Plant and Soil2000，218，： | 1 |
| 9 | Soil fauna alter the effects of litter composition on nitrogen cycling in a mineral soil 显示文摘 | Carrillo Y Ball BA Bradford MA Jordan CF Molina M | 2011 | Soil Biol Biochem2011，43，7： | 1 |
| 10 | Management of cardiac device- related infections: a review of protocol-driven care 显示文摘 | Rodriguez Y Garisto J Carrillo RG | 2013 | Int J Cardi- ol2013，166，： | 1 |
| 11 | Soil fauna alter theeffects of litter composition on nitrogen cycling in amineral soil显示文摘 | Carrillo Y Ball B A Bradford M A | 2011 | Soil Biology and Biochemistry2011，43，7： | 1 |
| 12 | Age- related changes in antioxidant enzyme activities are region and organ, as well as sex selective in the rat显示文摘 | Carrillo MC Kanai S Sato Y | 1992 | Mech Ageing Dev1992，65，： | 1 |
| 13 | Neuroprotection by propargylamines in Parkimon's disease:suppression of apoptosis and induction of prosurvival genes显示文摘 | Maruyama W Akao Y Carrillo MC | 2002 | Neurotoxicol Teratol2002，24，5： | 1 |
| 14 | Controls over soil ni- trogen pools in a semiarid grassland under elevated CO2 and war- ming显示文摘 | Carrillo Y Dijkstra F A Pendall E | 2012 | Ecosystems2012，15，5： | 1 |
| 15 | Controls over soil nitro- gen pools in a semiarid grassland under elevated CO2 and warming 显示文摘 | Carrillo Y Dijkstra F A Pendall E | 2012 | Ecosystems2012，15，5： | 1 |
| 16 | Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes 显示文摘 | Maruyama W Akao Y Carrillo MC a al | 2002 | Neurotoxicol Teratol2002，24，5： | 1 |
| 17 | Sequential-changes in activities of superoxide-dismutase and catalase in brain-regions and liver during (-)deprenyl infusion in male-rats显示文摘 | MC Carrillo S Kanai Y Sato | 1992 | Biochemical Pharmacology1992，44，11： | 1 |
| 18 | The influence of litter composition across the litter-soil interface on mass loss,nitrogen dynamics and the decomposer community显示文摘 | BALL B A CARRILLO Y MOLINA M | 2014 | Soil Biology and Biochemistry2014，69，： | 1 |
| 19 | Rhizosphere priming: a nutrient perspective 显示文摘 | Dijkstra F A Carrillo Y Pendall E Morgan J A | 2013 | Frontiers in Microbiology2013，4，1： | 1 |
| 20 | Neuroprotection by propargylamines in Parkinson's disease:suppression of apoptosis and induction of prosurvival genes显示文摘 | Maruyama W Akao Y Carrillo MC | 2002 | Neurotoxicol Teratol2002，24，5： | 1 |
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