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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Orthostatic hypotension,an often-neglected problem in community-dwelling older people:discrepancies between studies and real life显示文摘Orthostatic hypotension (OH)is a common condition in older persons.According to the 2011criteria,OH is defined by a sustained reduction of systolic blood pressure of 20 mmHg or a 10mmHg-fall of diastolic blood pressure,[1] Its prevalence increases with age and according to a recent systematic review the pooled prevalence in community dwelling older people is 22.2%.[2]Although OH is largely explained by concurrent clinical conditions (in particular, hypertension,diabetes,malnutrition,vascular encephalopa- thy,anemia,Parkinson's disease)[3],aging per se determines a series of physiological dysfunctions potentially representing its biological substratum (e.g.,reduction in barore- flex-mediated cardiovascular function,altered salt and water balance at renal level,impaired cardiac diastolic filling).It is also noteworthy that age-related changes in pharmacokinetic and pharmacodynamic mechanisms of drugs (especially in the context of polypharmacy)also increase the risk of OH. | Sarah Damanti Dario Consormi Annalisa Valentini Benedetta Cerasoli Martina Biotto Federica Conti Marta Clerici Pasqualina Iannuzzi Emanuela Manzo Paolo D Rossi Simona Ciccone Matteo Cesari | 2018 | Journal of Geriatric Cardiology2018，15，10： | 2 |
| 3 | Orthostatic hypertension and adverse clinical outcomes in adults and older people显示文摘Orthostatic hypertension(OHT)is a condition characterized by an increase in blood pressure after assuming the standing position.[1]Nowadays no consensus definition exists,thus OHT prevalence varies among studies(4%-20.3%). | Sarah Damanti Paolo D Rossi Matteo Cesari | 2021 | Journal of Geriatric Cardiology2021，18，9： | 2 |
| 4 | Ischemi8c precionditioning reduces Na + acculmulation and cell killing in isolated rat hepatocytes to hypoxia显示文摘 | Martcacrazia D Cesaris RC Splendere R | 2000 | Hepatology2000，31，： | 1 |
| 5 | Purinergic P2Y2 receptors promote hepato cyte resistance to hypoxia显示文摘 | Carini R Alchera E De Cesaris M G Splendore R Piranda D Baldanzi G | 2006 | J Hepatol2006，45，： | 1 |
| 6 | Mesenchymal chondrosarcoma : prognostic factors and outcome in 113 pationts : a European Musculoskeletal Oncology Society Study 显示文摘 | Frezza AM Cesari M Baumhore D | 2015 | Eur J Cancer2015，5，13： | 1 |
| 7 | Characterisation and source ap- portionment of PMto in an urban background site in Lecce显示文摘 | CONTINI D GENGA A CESARI D | 2010 | Atmos- pheric Resetch2010，95，1： | 1 |
| 8 | Increased density of the platelet serotonin transporter in autism显示文摘 | MARAZZITI D MURATORI F CESARI A | 2000 | Pharmacopsychiatry2000，33，： | 1 |
| 9 | Plasma adiponectin for prediction of cardiovascular events and mortality in high risk patients 显示文摘 | Maiolino G Cesari M Sticchi D | 2008 | J Clin Endocrinol Metab2008，93，： | 1 |
| 10 | Is homocysteine important as risk factor for cornary heart diseases 显示文摘 | Cesari I Rossi GP Sticchi D | 2005 | Nutr Metab Carduivasc Dis2005，15，2： | 1 |
| 11 | Stress response of a boreo-alpine species of tardigrade,Borealibius zetlandicus(Eutardigrada,Hypsibiidae)显示文摘 | REBECCHI L BOSCHINI D CESARI M | 2009 | Journal of Limnology2009，68，1： | 1 |
| 12 | Is homocysteine important as risk factor for coronary heart diseases? 显示文摘 | Cesari M Rossi GP Sticchi D | 2005 | Nutr Metab Cardiovasc Dis2005，15，2： | 1 |
| 13 | Source apportionment of size-segregated atmospheric particles based on the major water- soluble components in Lecce (Italy) 显示文摘 | Contini D Cesari D Genga A | 2014 | Science of the Total Environment2014，472，： | 1 |
| 14 | A new human transporter associated with antigen processing alleles encodes a large C-terminal protein domain显示文摘 | Maya M. Cesari Sophie J. Dulay Henri Caillens Christine Robert Claude Rouch Frédéric Cadet M. Pabion | 1997 | Immunogenetics1997，，4： | 1 |
| 15 | Safety and efficacy of a sec- ond-generation cryoballoon in the ablation of paroxysmal atria fibril- lation 显示文摘 | Martins RP Hamon D Cesari O | 2014 | Heart Rhythm2014，11，3： | 1 |
| 16 | Benchmarking,portfolio insurance and technical analysis:a Monte Carlo comparison of dynamic strategies of asset allocation显示文摘 | Cremonini D | 2003 | Journal of Economic Dynamics and Control2003，27，6： | 1 |
| 17 | Multidrug resistance-associated protein (MRP1) is overexpressed in DNA aneuploid carcinomatous cells in non-small cell lung cancer (NSCLC)显示文摘 | Doubre H Cesari D Mairovitz A | 2005 | Int J Cancer2005，113，4： | 1 |
| 18 | Presence of membrane and soluble forms of Fas ligand and of matrilysin (MMP-7) activity in normal and abnormal human semen显示文摘 | RICCIOLI A SECCO D V CESARIS D P | 2005 | Hum Reprod2005，20，10： | 1 |
| 19 | Safety and efficacy of a second- generation cryoballoon in the ablation of paroxysmal atrial fibrillation 显示文摘 | Martins RP Hamon D Cesari O | 2014 | Heart Rhythm2014，11，3： | 1 |
| 20 | Multidrug resistance-associated pretein(MRP1 ) is overexpressed in DNA aneuploid carcinomatous cells in non-small cell lung cancer (NSCLC)显示文摘 | Doubre H Cesari D Mairevitz A | 2005 | Int J Cancer2005，113，4： | 1 |
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