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| 1 | 电子束增材制造医用钛合金三维多孔支架力学及生物功能研究进展(英文)显示文摘本文综述了电子束增材制造法(EBM)制备医用钛合金多孔支架植入物的工艺-结构-性能之间关系.传统加工多孔材料方法(如冷冻铸造及烧结法)制备的多孔植入器械由于很难匹配患病部位以及与人体组织在宏微观结构、力学和物理性能存在差异等因素受到很多限制.针对这一问题,EBM方法具有独特的优势.它可以利用患病部位的CT扫描成像或者CAD程序设计制备出复杂个性化多孔植入器械.本文概述了用于组织再生3D打印多孔支架的发展历程,主要包含两部分:第一部分介绍了EBM法制备的具有不同特征(设计、结构单元、加工参数、扫描速率、孔隙率及热处理)钛合金多孔支架的力学性能;第二部分介绍了多孔支架生物响应的改进优化以及表面改性对细胞-材料交互作用的研究进展.最后,本文还讨论了三维多孔钛合金支架的临床试验结果,并展望了其在生物医疗领域的应用前景. | Krishna Chaitanya Nune 李述军 R.Devesh Kumar Misra | 2018 | Science China Materials2018，61，4： | 11 |
| 2 | Role of the endothelium in inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of the disease.At the core of these alterations are endothelial cells,whose continual adjustments in structure and function coordinate vascular supply,immune cell emigration,and regulation of the tissue environment.Expansion of the endothelium in IBD(angiogenesis),mediated by inflammatory growth factors,cytokines and chemokines,is a hallmark of active gut disease and is closely related to disease severity.The endothelium in newly formed or inflamed vessels differs from that in normal vessels in the production of and response to inflammatory cytokines,growth factors,and adhesion molecules,altering coagulant capacity,barrier function and blood cell recruitment in injury.This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelium contributing to these conditions. | Walter E Cromer J Michael Mathis Daniel N Granger Ganta V Chaitanya J Steven Alexander | 2011 | World Journal of Gastroenterology2011，17，5： | 10 |
| 3 | Enhanced myocardial fluorodeoxyglucose uptake following Adriamycin-based therapy: Evidence of early chemotherapeutic cardiotoxicity?显示文摘AIM: To analyze changes in myocardial glucose metabolism using fluorodeoxyglucose (FDG)-positron emission tomography (PET) in patients treated with adriamycin and to investigate the clinical significance of these changes.METHODS: Considering that FDG-PET scanning has the ability to show changes in glucose metabolism in the myocardium, we retrospectively analyzed the FDGPET studies of 18 lymphoma patients treated with adriamycin-based chemotherapy in both the preand posttherapy setting. Cardiac contractile parameters such as left ventricular ejection fraction were not available for correlation in all patients due to the short duration and the level of cumulative dose administered in these patients during the time of the follow-up FDG-PET study. The change in myocardial glucose utilization was estimated by change in standard uptake values (SUV) in the myocardium.RESULTS: We observed a significant change in SUVmean values in the myocardium (defined as more than change in cardiac SUVmean between pre-and post-chemotherapy PET) in 1 patients, whereas 6 patients did not show any significant cardiac FDG uptake in both preand post-therapy PET scans. Patients were divided into three groups based on the changes observed in myocardial tracer uptake on the followup 18 F-FDG-PET study. Group A (n = 8): showed an increase in cardiac 18 F-FDG uptake in the post-therapy scan compared to the baseline scan carried out prior to starting adriamycin-based chemotherapy. Group B (n = 6): showed no significant cardiac 18 F-FDG uptake in post-therapy and baseline PET scans, and group C (n = 4): showed a fall in cardiac 18 F-FDG uptake in the posttherapy scan compared to the baseline scan. Mean cumulative adriamycin dose (in mg/m 2 ) received during the time of the follow-up FDG-PET study was 256. 25, 250 and 137.5, respectively.CONCLUSION: Our study shows three different trends in the change in myocardial glucose metabolism in patients undergoing adriamycin-based chemotherapy. A further prospective study with prolonged follow-up of ventricular function is warranted to explore the significance of enhanced FDG uptake as a marker of early identification of adriamycin-induced cardiotoxicity. | Chaitanya Borde Purushottam Kand Sandip Basu | 2012 | World Journal of Radiology2012，4，5： | 9 |
| 4 | Mortality associated with gastrointestinal bleeding in children: A retrospective cohort study显示文摘AIM To determine the clinical characteristics of children with gastrointestinal bleeding (GIB) who died during the course of their admission.METHODS We interrogated the Pediatric Hospital Information System database, including International Classification of Diseases, Current Procedural Terminology and Clinical Transaction Classification coding from 47 pediatric tertiary centers extracting the population of patients (1-21 years of age) admitted (inpatient or observation) with acute, upper or indeterminate GIB(1/2007-9/2015). Descriptive statistics, unadjusted univariate and adjusted multivariate analysis of the associations between patient characteristics and treatment course with mortality was performed with mortality as primary and endoscopy a secondary outcome of interest. All analyses were performed using the R statistical package, v.3.2.3. RESULTS The population with GIB was 19528; 54.6% were male, overall mortality was 2.07%;(0.37% in patients with the principal diagnosis of GIB). When consideringonly the mortalities in which GIB was the principal diagnosis, 48% (12 of 25 principal diagnosis GIB mortalities) died within the first 3 d of admission, whereas 19.8% of secondary diagnosis GIB patients died with 3 d of admission. Patients who died were more likely to have received octreotide (19.8% c.f. 4.04%) but tended to have not received proton pump inhibitor therapy in the first 48 h, and far less likely to have undergone endoscopy during their admission(OR = 0.489, P < 0.0001). Chronic liver disease associated with a greater likelihood of endoscopy. Mortalities were significantly more likely to have multiple complex chronic conditions. CONCLUSION GIB associated mortality in children is highest within 7 d of admission. Multiple comorbidities are a risk factor whereas early endoscopy during the admission is protective. | Thomas M Attard Mikaela Miller Chaitanya Pant Ashwath Kumar Mike Thomson | 2017 | World Journal of Gastroenterology2017，23，9： | 6 |
| 5 | 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents显示文摘In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme. | Erin Marie Kirwen Tarun Batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala Amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle Mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 3 |
| 6 | Potential role of noninvasive biomarkers during liver fibrosis显示文摘Various types of liver disease exist,such as hepatitis and alcoholic liver disease.These liver diseases can result in scarring of liver tissue,cirrhosis,and finally liver failure.During liver fibrosis,there is an excess and disorganized accumulation of extracellular matrix(ECM)components which cause the loss of normal liver cell functions.For patients with chronic liver disease,fibrosis prediction is an essential part of the assessment and management.To diagnose liver fibrosis,several invasive and noninvasive markers have been proposed.However,the adoption of invasive markers remains limited due to their inherent characteristics and poor patient acceptance rate.In contrast,noninvasive markers can expedite the clinical decision through informed judgment about disease stage and prognosis.These noninvasive markers are classified into two types:Imaging techniques and serum biomarkers.However,the diagnostic values of biomarkers associated with liver fibrosis have also been analyzed.For example,the serum levels of ECM proteins can react to either matrix accumulation or degradation.During virus-host interactions,several regulatory steps take place to control gene expression,such as the change in cellular microRNA expression profiles.MicroRNAs are a class of non-coding RNAs(18-20 long nucleotides)that function by post-transcriptional regulation of gene expression.Although various noninvasive markers have been suggested in recent years,certain limitations have restricted their clinical applications.Understanding the potential of non-invasive biomarkers as a therapeutic option to treat liver fibrosis is still in progress. | Navneet Kaur Gitanjali Goyal Ravinder Garg Chaitanya Tapasvi Sonia Chawla Rajneet Kaur | 2021 | World Journal of Hepatology2021，13，12： | 3 |
| 7 | Cu–Co–O nano-catalysts as a burn rate modifier for composite solid propellants显示文摘Nano-catalysts containing copper–cobalt oxides(Cu–Co–O) have been synthesized by the citric acid(CA) complexing method. Copper(II) nitrate and Cobalt(II) nitrate were employed in different molar ratios as the starting reactants to prepare three types of nano-catalysts. Well crystalline nano-catalysts were produced after a period of 3 hours by the calcination of CA–Cu–Co–O precursors at 550 °C. The phase morphologies and crystal composition of synthesized nano-catalysts were examined using Scanning Electron Microscope(SEM), Energy Dispersive Spectroscopy(EDS) and Fourier Transform Infrared Spectroscopy(FTIR) methods. The particle size of nano-catalysts was observed in the range of 90 nm–200 nm. The prepared nano-catalysts were used to formulate propellant samples of various compositions which showed high reactivity toward the combustion of HTPB/AP-based composite solid propellants. The catalytic effects on the decomposition of propellant samples were found to be significant at higher temperatures. The combustion characteristics of composite solid propellants were significantly improved by the incorporation of nano-catalysts. Out of the three catalysts studied in the present work, Cu Co-I was found to be the better catalyst in regard to thermal decomposition and burning nature of composite solid propellants. The improved performance of composite solid propellant can be attributed to the high crystallinity, low agglomeration and lowering the decomposition temperature of oxidizer by the addition of Cu Co-I nano-catalyst. | D. Chaitanya Kumar RAO Narendra YADAV Puran Chandra JOSHI | 2016 | Defence Technology(防务技术)2016，12，4： | 3 |
| 8 | Acid‐suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients: A meta‐analysis显示文摘 | Abhishek Deshpande Vinay Pasupuleti Priyaleela Thota Chaitanya Pant Sulaiman Mapara Sohaib Hassan David D K Rolston Thomas J Sferra Adrian V Hernandez | 2013 | J Gastroenterol Hepatol2013，，2： | 3 |
| 9 | Monolith多尺度模型前沿进展:从有限元方法到机器学习显示文摘Monolith催化器被广泛用于移动源和固定源的废气净化,是气相催化体系中的关键优化对象。计算模拟的方法有助于进一步理解monolith中宏微观耦合的多尺度物理与化学过程,实现催化体系的快速评估,促进废气后处理催化体系的更新迭代与技术升级。总结了monolith多尺度模型的总体框架,详细讨论了建模过程中涉及到的催化器内部物质与能量的扩散、反应动力学、流动均匀性等基本原理与过程,综述了不同尺度模型的有限元求解方法特点与近年来结合机器学习模型的前沿进展。最后对monolith多尺度建模领域面临的挑战与发展趋势进行了展望。 | 单斌 陈荣昕 杨家强 Chaitanya Sampara | 2022 | 金属功能材料2022，29，3： | 3 |
| 10 | Drought-induced responses of photosynthesis and antioxidant metabolism in higher plants显示文摘 | Attipalli Ramachandra Reddy Kolluru Viswanatha Chaitanya Munusamy Vivekanandan | 2004 | Journal of Plant Physiology2004，，11： | 2 |
| 11 | 糖尿病酮症酸中毒患者发生胃肠道出血的预测因素:一项回顾性的观察研究显示文摘背景酮症酸中毒(DKA)是糖尿病一种常见的急性并发症,需要积极的药物治疗。我们旨在研究DKA患者急性胃肠道出血(AGIB)和急性上消化道出血(AUGIB)的发生率及其相关危险因素。方法:我们对本中心2010年1月至2015年12月间收治的DKA病例进行回顾性分析,通过电子病历库收集其人口统计学、临床、实验室、内镜及住院资料。根据有无发生胃肠道出血将患者分为两组。结果:共计234例DKA患者纳入研究,其中27例(11.5%)有AGIB的记录。除2例直肠出血和3例隐匿性出血外,22例(9.4%)表现为呕血。AGIB组与非AGIB组患者年龄、性别和种族的分布无显著差异。两组患者电解质水平、阴离子间隙、pH值及糖化血红蛋白HbA1c的差异亦无统计学意义。然而,AGIB组患者初始血糖水平显著高于非AGIB组(738 mg/dL vs 613 mg/dL,P=0.014)。AGIB组患者病死率也有所升高(7.4%vs 4.8%),尽管差异未达到统计学意义。结论:初始高血糖水平会增加DKA患者发生AGIB的风险。我们还注意到发生AGIB的DKA患者病死率增加,尽管这个增加未达到统计学意义。临床上应更加积极地纠正DKA患者的血糖水平以降低AGIB发生率,从而降低住院病死率。 | Kanthi Rekha Badipatla Preeti Jadhav Sushma Vaddigiri Bharat Bajantri Amandeep Singh Chaitanya Chandrala Vijay S Are Suresh Kumar Nayudu | 2017 | Gastroenterology Report2017，5，4： | 2 |
| 12 | Isolation,characterization and differentiation potential of rat bone marrow stromal cells显示文摘 | Polisetti N Chaitanya VG Babu PP | | 0，，02： | 1 |
| 13 | Variation in stress-nclucecl antioxiclant enzyme activities among threemulberry euhivars显示文摘 | Chaitanya K V Sundar I) Masilamani S | 2002 | Plant Growth Regulation2002，36，： | 1 |
| 14 | Drought-induced re- sponses of photosynthesis and antioxidant metabolism in higher plants 显示文摘 | Reddy A R Chaitanya K V Vivekanandan M | 2004 | J Plant Physiol2004，161，： | 1 |
| 15 | Multiple apoptogenic proteins are involved inthe nuclear translocation of apoptosis inducing factor during transientfocal cerebral ischemia in rat显示文摘 | Chaitanya GV Babu PP | 2008 | Brain Res2008，1246，： | 1 |
| 16 | Mulberry leaf metabolism under high temperature stress 显示文摘 | Chaitanya K V Sundar D Reddy A R | 2001 | Biologia Plantarum2001，44，： | 1 |
| 17 | The microstructure and mechanical properties of friction stir welded A1-Zn-Mg alloy in as welded and heat treated conditions 显示文摘 | Singh R K R Chaitanya Sharma D K | 2011 | Materials and Design2011，32，2： | 1 |
| 18 | Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits显示文摘 | Vandana Dongare Chaitanya Kulkarni Manish Kondawar Chandrakant Magdum Vivek Haldavnekar Akalpita Arvindekar | 2011 | Food Chemistry2011，，1： | 1 |
| 19 | First princi- ples prediction of partitioning of alloying elements between cementite and ferrite显示文摘 | Chaitanya Krishna Ande Marcel H F Sluiter | 2010 | Acta Mater2010，58，： | 1 |
| 20 | Isolation,characterization and differentiation potential of rat bone marrow stromal cells显示文摘 | Polisetti N Chaitanya VG Babu PP | 2010 | Neurol India2010，58，2： | 1 |
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