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| 1 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 2 | DEK43 is a P-type pentatricopeptide repeat(PPR)protein responsible for the Cis-splicing of nad4 in maize mitochondria显示文摘Mitochondria, the main energy transducers in plant cells, require the proper assembly of respiratory chain complexes Ⅰ–Ⅴ for their function. The NADH dehydrogenase4(nad4) gene encodes mitochondrial respiratory chain complex Ⅰ subunit Ⅳ, but the mechanism underlying nad4 transcript splicing is unclear. Here, we report that the P-type pentatricopeptide repeat(PPR) protein DEFECTIVE KERNEL 43(DEK43) is responsible for cis-splicing of the nad4 transcript in maize. We demonstrate that DEK43 localizes to both the nucleus and mitochondria. The mutation of Dek43 resulted in embryo-lethal and light-colored defective kernels. Among the 22 mitochondrial group Ⅱ introns, the splicing efficiency of nad4 introns 1 and 3 was reduced by up to 50% compared to the wild type. The levels of complex Ⅰ and supercomplex Ⅰ+Ⅲ2 were also reduced in dek43. Furthermore, in-gel NADH dehydrogenase assays indicated that the activities of these complexes were significantly reduced in dek43. Further, the mitochondrial ultrastructure was altered in the mutant. Together, our findings indicate that DEK43, a dual-localized PPR protein,plays an important role in maintaining mitochondrial function and maize kernel development. | Ru Chang Ren Li Li Wang Lin Zhang Ya Jie Zhao Jia Wen Wu Yi Ming Wei Xian Sheng Zhang Xiang Yu Zhao | 2020 | Journal of Integrative Plant Biology2020，62，3： | 6 |
| 3 | Guidelines for the diagnosis and treatment of chronic pancreatitis in China(2018 edition)显示文摘Chronic pancreatitis(CP)is a progressive inflammatory disease of pancreas that alters the organ’s normal structure and functions.CP seriously affects the quality of life of patients and greatly increases the public medical burden of society.In recent years,the incidence of CP has increased worldwide.The concepts of etiology and therapies have been continuously updated. | Wen-Bin Zou Nan Ru Hao Wu Liang-Hao Hu Xu Ren Gang Jin Zheng Wang Yi-Qi Du Ya-Nan Cao Lei Zhang Xiao-Yan Chang Rong-Chun Zhang Xiao-Bin Li Yan Shen Peng Li Zhao-Shen Li Zhuan Liao Pancreatitis Group of Chinese Medical Doctor Association | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 6 |
| 4 | Fenvalerate-induced Alterations in Calcium Homeostasis in Rat Ovary显示文摘Objective To observe the effects of fenvalerate on calcium homeostasis in rat ovary. Methods Female Sprague- Dawley rats were orally given fenvalerate at daily doses of 0.00, 1.91, 9.55, and 31.80 mg/kg for four weeks. The ovary ultrastucture was observed by electron microscopy. Serum free calcium concentration was measured by atomic absorption spectrophotometry. The activities of phosphorylase a in rat ovary were evaluated by the chromatometry. The total content of calmodulin in ovary was estimated by ELISA at each stage of estrous cycle. Radioimmunoassay (RIA) was used to evaluate the level of serum progesterone. Results Histopathologically, damages of ovarian corpus luteum cells were observed. An increase in serum free calcium concentration was observed in rats treated with 31.80mg/kg fenvalerate. The activities of phosphorylase a enhanced in all treated groups, and fenvalerate increased the total content of calmodulin significantly in estrus period. Serum progesterone levels declined in fenvalerate exposed rats in diestrus. Conclusion Fenvalerate interferes with calcium homeostasis in rat ovary. Also, the inhibitory effects of fenvalerate on serum progesterone levels may be mediated partly through calcium signals. | JUN HE JIAN-FENG CHEN RU LIU LIN SONG HEBRON C. CHANG AND XIN-RU WANG | 2006 | Biomedical and Environmental Sciences2006，19，1： | 5 |
| 5 | Effect of sulfate solu- tion on the frost resistance of concrete with and without steel fiber reinforce - ment 显示文摘 | MIAO Chang - wen MU Ru TIAN Qian | 2002 | Cement and Concrete2002，32，1： | 1 |
| 6 | Toughening mechanisnms in iroreeontaining/titanium composites 显示文摘 | Chang Q Chen D L Ru H O | 2010 | Biomaterials2010，31，7： | 1 |
| 7 | Numerical simulation and experimental research on indoor environment separated with down-feed air curtain 显示文摘 | GUO CHUN-ME ZHANG YU-FENG CHANG RU | 2009 | Tianjin University and Spreinger-Verlag2009，，15： | 1 |
| 8 | Design, Synthesis and in vitro Evaluation of Thiazole Derivatives of Ibuprofen as Cyclooxygenase-2 Inhibitors显示文摘A series of thiazole derivatives of ibuprofen, as cyclooxygenase-2 Inhibitors, were designed, synthesized and in vitro evaluated. | Chang Bin GUO Zhe Feng CAI Zong Ru GUO Zhi Qiang FENG Feng Ming CHU Gui-Fang CHENG | 2006 | Chinese Chemical Letters2006，17，3： | 1 |
| 9 | 1-(2-Formamidoethyl)-3-phenylurea functionalized activated carbon for selective solid-phase extraction and preconcentration of metal ions显示文摘 | Zhifeng Tu Qun He Xijun Chang Zheng Hu Ru Gao Lina Zhang Zhenhua Li | 2009 | Analytica Chimica Acta2009，，2： | 1 |
| 10 | Design and analysis of GUI test-case prioritization us- ing weight-based methods 显示文摘 | Chin- Yu Huang Jun- Ru Chang Yung- Hsin Chang | 2010 | The journal of Systems and Software2010，83，4： | 1 |
| 11 | Photocatalytic decolorization and degradation of Congo Red on innovative crosslinked chitosan/nano-CdS composite catalyst under visible light irradiation显示文摘 | ZHU Hua-yue JIANG Ru XIAO Ling CHANG Yu-hua GUAN Yu-jiang LI Xiao-dong ZENG Guang-ming | 2009 | J Hazard Mater2009，169，123： | 1 |
| 12 | 显示文摘 | Chen Huang Yu Yang Ru Yuan Chang Shoou Jinn | 2012 | Materials Research Bulletin2012，47，： | 1 |
| 13 | Comparison of Overall Sexual Function, Sexual Intercourse/Ac- tivity, Sexual Satisfaction, and Sexual Desire During the Three Trimesters of Pregnancy and Assessment of Their Determinants 显示文摘 | Chang Shiow - Ru Chen Kuang - Ho Lin Ho - Hsiung | 2011 | The Journal of Sexual Medicine2011，8，10： | 1 |
| 14 | Phenol degradation in an electrochemical system with TiO2/activated carbon fiber as electrode显示文摘 | JIN Peipei CHANG Ru LIU Deqi | 2014 | Journal of Environmental Chemical Engineering2014，2，： | 1 |
| 15 | Leptospirosis:pathogenesis,immunity,and diagnosis显示文摘 | Palaniappan RU Ramanujam S Chang YF | 2007 | Curr Opin Infect Dis2007，20，3： | 1 |
| 16 | Harmonic DiffServ: Scalable Support of IP Multicast with QoS Heterogeneity in DiffServ Backbone Networks显示文摘 | Tong Sheau - Ru Chang Chun - Cheng | 2006 | Computer Communications2006，29，10： | 1 |
| 17 | Epigenetic Regulation Contributes to Urocortin‐Enhanced Midbrain Dopaminergic Neuron Differentiation显示文摘 | Hsin‐Yi Huang Tsung‐Lang Chiu Hui‐Fen Chang Hui‐Ru Hsu Cheng‐Yoong Pang Hock‐Kean Liew Mei‐Jen Wang | 2015 | Stem Cells2015，，5： | 1 |
| 18 | Study on concrete-filled stainless steel carbon steel tubular(CFSCT) stub columns under compression显示文摘 | CHANG XU RU ZHONGLIANG ZHOU WEI | 2013 | Thin-Walled Structures2013，63，： | 1 |
| 19 | Neuroprotective effects of oxysophocarpine on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion显示文摘 | Qing-Luan Zhu Yu-Xiang Li Ru Zhou Ning-Tian Ma Ren-Yuan Chang Teng-Fei Wang Yi Zhang Xiao-Ping Chen Yin-Ju Hao Shao-Ju Jin Lin Ma Juan Du Tao Sun Jian-Qiang Yu | 2014 | Pharmaceutical Biology2014，，8： | 1 |
| 20 | Application of back-propagation networks in debris flow prediction显示文摘 | Chang Tung chueng Chao Ru jen | 2006 | Engineering Geology2006，85，34： | 1 |
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