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| 1 | Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi′an显示文摘OverexpressionofP53anditsriskfactorsinesophagealcancerinurbanareasofXi′anQIAOGuiBin1,HANChengLong2,JIANGRenChao1,SUNChang?.. | QIAO GuiBin1, HAN ChengLong2, JIANG RenChao1, SUN ChangSheng3, WANG Yan3 and WANG YunJie3 | 1998 | World Journal of Gastroenterology1998，4，1： | 21 |
| 2 | A new naphthoquinoneimine derivative from the marine algal-derived endophytic fungus Aspergillus niger EN-13显示文摘也就是,从海洋的棕色的水藻 Colpomenia sinuosa 的内部织物被孤立的 endophytic 真菌曲霉属菌尼日尔 EN-13 的耕作导致了新 naphthoquinoneimine 衍生物的描述 5,7-dihydroxy-2-[1-(4-methoxy-6-oxo-6H-pyran-2-yl )-2-phenylethylamino]-[1,4]naphthoquinone。新混合物的结构包括 2D NMR 技术, EIMS,和 HR-ESI-MS 根据各种各样的 NMR 分光镜的分析被建立。这项复合显示的中等抗真菌的活动。 | Yi Zhang Xiao Ming Li Chang Yun Wang Bin Gui Wang | 2007 | Chinese Chemical Letters2007，18，8： | 7 |
| 3 | The apoptosis of HEL cells induced by hydroxyurea显示文摘Hydroxyurea has been used to synchronize cultured cells to S-phase and used to treat patients with sicklecell anemia. Recently, we found that hydroxyurea can induce the apoptosis of HEL (human erythroleukemia) cells.The induced HEL cells showed ultrastructurally chromatin condensation with regular crescents at the nuclear edges and apoptotic bodies. However, the cells of K562, another human erythroleukemia cell line, did not show such morphological changes. Under fluoroscope, the HEL cells after induction often displayed a clear reduction in nuclear diameter and nuclear chromatin cleavage and condensation and the presence of nuclear ring and apoptotic bodies. Analysis with flow cytometry showed that the percentage of apoptotic cells is about 30-40% after HEL cells were induced by hydroxyurea for 3 days. DNA ladder can be observed by electrophoretic analysis. | GUI CHANG YUN CHU JIANG HENG YUE XIE RUO LAN QIAN(Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031) | 1997 | Cell Research1997，7，1： | 2 |
| 4 | Diagnosis of functional constipation: Agreement between R ome III and R ome II criteria and evaluation for the practicality显示文摘 | Hai Wei Xin Xiu Cai Fang Li Ming Zhu Tao Xu Gui Jun Fei Zhi Feng Wang Min Chang Li Ying Wang Xiao Hong Sun Mei Yun Ke | 2014 | Journal of Digestive Diseases2014，，6： | 1 |
| 5 | STAT1 is involved in signal transduction in the EPOinduced HEL cells显示文摘Erythropoietin (EPO) is the ma jor regulator of mammalian erythropoisis, which stimulates the growth and differentiation of hematopoietic cells through interaction with its receptor (EPO-R). Here we use HEL cells (a human erythro-leukemia cell line) as a model to elucidate the pathway of signal transduction in the EPO-induced HEL cells. our data show that the EPOR (EPO receptor) on the surface of HEL cells interacts with the Janus tyrosine protein kinase (Jak2) to transduce intracellular signals through phosphorylation of cytoplasmic proteins in EPO-treated HEL cells. Both STAT1 and STAT5 in this cell line are tyrosine-phosphorylated and translocated to nucleus following the binding of EPO to HEL cells.Furthermore, the binding of both STAT1 and STAT5 proteins to specific DNA elements (SIE and PIE elements) is revealed in an EPO-dependent manner. Our data demonstrate that the pathway of signal transduction following the binding of EPO to HEL cells is similar to immature erythroid cell from the spleen of mice infected with anemia strain of Friend virus. | JIANG CHU CHANG YUN GUI JIE FAN XIAO DA TANG RUO LAN QIAO(Shanghai Institute of Cell Biology, Chinese Academy ofSciences, Shanghai 200031, China )(Dept. of Urology, Shanghai First People,s Hospital,Shanghai 200081, China) | 1998 | Cell Research1998，8，2： | 0 |
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