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| 1 | Common misconceptions about 5-aminosalicylates and thiopurines in inflammatory bowel disease显示文摘Misconceptions are common in the care of patients with inflammatory bowel disease(IBD).In this paper,we state the most commonly found misconceptions in clinical practice and deal with the use of 5-aminosalicylates and thiopurines,to review the related scientificevidence,and make appropriate recommendations.Prevention of errors needs knowledge to avoid making such errors through ignorance.However,the amount of knowledge is increasing so quickly that one new danger is an overabundance of information.IBD is a model of a very complex disease and our goal with this review is to summarize the key evidence for the most common daily clinical problems.With regard to the use of 5-aminosalicylates,the best practice may to be consider abandoning the use of these drugs in patients withsmall bowel Crohn's disease.The combined approach with oral plus topical 5-aminosalicylates should be the first-line therapy in patients with active ulcerative colitis;once-daily treatment should be offered as a first choice regimen due to its better compliance and higher efficacy.With regard to thiopurines,they seem to be as effective in ulcerative colitis as in Crohn's disease.Underdosing of thiopurines is a form of undertreatment.Thiopurines should probably be continued indefinitely because their withdrawal is associated with a high risk of relapse.Mercaptopurine is a safe alternative in patients with digestive intolerance or hepatotoxicity due to azathioprine.Finally,thiopurine methyltransferase(TPMT)screening cannot substitute for regular monitoring because the majority of cases of myelotoxicity are not TPMT-related. | Javier P Gisbert María Chaparro Fernando Gomollón | 2011 | World Journal of Gastroenterology2011，17，30： | 8 |
| 2 | Long-term outcome of chronic hepatitis C patients with sustained virological response to peginterferon plus ribavirin显示文摘AIM: To assess the clinical, biochemical and virological long-term outcome in chronic hepatitis C (CHC) patients with a sustained virological response (SVR) after peginterferon (PEG-IFN) plus ribavirin combination therapy. METHODS: One hundred and fifty three patients with a SVR after treatment with PEG-IFN plus ribavirin were included in a 5-year follow-up study in a single Spanish center, based on standard clinical practice. Clinical anamnesis, biochemical analysis, hepatitis C virus RNA and alpha-fetoprotein measurement, ultrasonography and transient elastography were performed annually. RESULTS: The mean follow-up period of the 153 patients was 76 ± 13 mo after they obtained a SVR. Five patients (3.26%) presented with cirrhosis before treatment and 116 (75.8%) had genotype 1. No patient showed evidence of hepatic decompensation. One patient (0.65%) developed a hepatocellular carcinoma at month 30 after achieving SVR. There were no virological relapses during this follow-up period. Persistently elevated alanine aminotransferase was found in only one patient (0.65%). At the end of the 5-year follow-up, the mean value of transient elastography was 7 ± 4.3 kPa (F1). There were no deaths and no other tumors. CONCLUSION: The long-term outcome of 153 CHC patients with SVR to PEG-IFN plus ribavirin was good. No evidence of a virological relapse was seen. One patient (0.65%) developed a hepatocellular carcinoma. | María Trapero-Marugán Jorge Mendoza María Chaparro Leticia González-Moreno José Andrés Moreno-Monteagudo María Jesús Borque Ricardo Moreno-Otero | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 3 | Changes in feeding mechanisms during early ontogeny in juveniles of Crepidula fecunda (Gastropoda, Calyptraeidae)显示文摘 | Montiel Y A Chaparro O R Segura C J | 2005 | Marine Biology2005，147，： | 1 |
| 4 | Should we monitor vitamin B<sub>12</sub> and folate levels in Crohn’s disease patients?显示文摘 | Fernando Bermejo Alicia Algaba Ivá n Guerra Marí a Chaparro Gema De-La-Poza Paz Valer Belé n Piqueras Andrea Bermejo Javier Garcí a-Alonso Marí a-José Pé rez Javier P Gisbert | 2013 | Scandinavian Journal of Gastroenterology2013，，11： | 1 |
| 5 | Levels of interleukin-17 in gingival erevieular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis 显示文摘 | Vernal R Dutzan N Chaparro A | 2005 | J Clin Periodontol2005，32，4： | 1 |
| 6 | The ToxT dependent methyl-ac- cepting chemoreceptors AcfB and Tcpl contribute to Vibrio cholerae intestinal colonization 显示文摘 | Chaparro A P All S K Klose K E | 2010 | Ferns Mierobiol Lett2010，302，2： | 1 |
| 7 | Pbysico-chemical study of the degradation of membrane-electrode assemblies in a proton exchange membrane fuel cell stack显示文摘 | Ferreira-Aparicio P Gallardo-L6pez B Chaparro A M | 2011 | Journal of Power Sources2011，196，9： | 1 |
| 8 | Electrochemical growth and properties of CulnS2 thin films for solar energy conversion显示文摘 | ASENJO B CHAPARRO A M GUTI(E)RREZ M T | 2006 | Thin Solid Films2006，，： | 1 |
| 9 | Design, construction and testing of an apricot tractor-trailed harvester显示文摘 | Torregrosa A Chaparro O Martin B | 2008 | Spanish Joumal of Agricultural Research2008，6，3： | 1 |
| 10 | Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis显示文摘 | Vernal R Dutzan N Chaparro A | 2005 | Clin Periodontal2005，32，： | 1 |
| 11 | Effect of timing of umbilical cord clamping on iron status in Mexie infants: a randomised controlled trial显示文摘 | Chaparro C M Neufeld L M Tena A G | 2006 | Lancet2006，367，527： | 1 |
| 12 | Levels of interleukine-17 in gingival ezevicu]ar fluid and in supematants of cellular cultures of gingi- val tissue from patients with chronic periodontitis显示文摘 | Vem/l R Dutzan N Chaparro A | 2005 | J Clin Periodontal2005，32，4： | 1 |
| 13 | Osteoporosis and lung transplantation:a prospective study显示文摘 | Spira A Gutierrez C Chaparro C | | 0，，02： | 1 |
| 14 | Magnetic studies applied to different environments (soils and stream sediments) from a relatively polluted area in Buenos Aires Province,Argentina显示文摘 | CHAPARRO M A E BIGEGAIN J C SINITO A M | 2004 | Environmental Geology2004，45，： | 1 |
| 15 | 显示文摘 | Chaparro A M Martinez M A Guillen C | 2000 | Thin Solid Films2000，，2： | 1 |
| 16 | Levels of cytokine receptor activator of nuclear factor к B ligund in gingival crevicular fluid in untreated chronic periodontitis patients显示文摘 | Chaparro A Graumann R | 2004 | J Periodontol2004，75，： | 1 |
| 17 | Stimulatory response of neutrophils from periodontitis patients with periodontal pathogens显示文摘 | RESTAINO CG CHAPARRO A VALENZUELA MA | 2007 | Oral Dis2007，13，5： | 1 |
| 18 | Elec- trochemical growth and properties of CulnS2 thin films for solar energy conversion 显示文摘 | Asenjo B Chaparro A M Gutie? rrez M T | 2006 | Thin Solid Films2006，，： | 1 |
| 19 | The ToxT-dependent methyl-accepting chemoreceptors AcfB and TcpI contrib- ute to Vibrio eholerae intestinal colonization 显示文摘 | Chaparro A P Ali S K Klose K E | 2010 | FEMS Microbiology Letters2010，302，2： | 1 |
| 20 | Inheritance of the Blood-flesh Trait in Peach 显示文摘 | Werner DJ Creller M A Chaparro J X | 1998 | HortScience1998，33，： | 1 |
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