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    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2Associations of leptin gene polymorphisms with production traits in pigs 显示文摘De Oliveira Peixoto J Facioni Guimar?es S E Savio Lopes P 2006J Anita Breed Genet2006,123,6:1
3The sentinel fat pads: the relationship of the ROOF and SOOF to the tem- poral nerve in facial rejuvenation显示文摘SINGH D P FORTE A J APOSTOLII)ES J G el al 2011Aesthet Surg J2011,31,1:1
4Global existence theory for ageneralized Ginzburg-Landau equation显示文摘Duan J Holmes P Titi ES 1992Nonlinearity1992,5,6:1
5Ball recovery patterns as a performance indicator in elite soccer 显示文摘Barreira D Garganta J Guimar?es P 2014Proceedings of the Institution of Mechanical Engineers Part P Journal of Sports Engineering & T echnology2014,228,1:1
6Infection of CD127+ (interleukin-7 receptor + ) CD4+ ceils and overexpression of CTLA-4 are linked to loss of antigen- specific CD4 T cells during primary human immunodeficiency virus type 1 infection 显示文摘Zaunders JJ Ip S Munier ML Kaufmann DE Suzuki K Brereton C Sasson SC Seddiki N Koelsch K Landay A Grey P Finlayson R Kaldor J Rosenberg ES Walker BD Fazekas de St Groth B Cooper DA Kelleher AD 2006J Virol2006,80,10:1
7Mapmaker:an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations显示文摘Lander ES Green P Abrahamson J 1987Genomics1987,1,:1
8Application of CFD in the study of supercritical fluid extraction with structured packing: wet pressure drop calculations显示文摘FERNANDES J LISBOA P F SIM(7)ES P C 2009The Journal of SupercriticalFluids2009,50,1:1
9Pharmacokinetics of betamethasone in twin and singleton pregnancy 显示文摘Ballabh P Lo ES Kumari J 2002Clin Pharmacol Ther2002,71,1:1
10Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury显示文摘Fu ES Zhang Y P Sagen J 2010Pain2010,148,3:1
11Malignant hyperthermia显示文摘Es Halsall P J Philip M 2003Br J Anaesth2003,12,3:1
12Application of CFD in the study of supercritical fluid extraction with structured packing:Wetpressure drop calculations显示文摘Fernandes J Lisboa P F Sim?es P C 2009Supercritical Fluids2009,50,:1
13The amygdaloid complex:anatomy and physiology显示文摘Sah P Faber ES Power J 2003Physiol Rev2003,83,3:1
14Follicular,papillary,and“hybrid”carcinomas of the thyroid显示文摘Castro P Fonseca E Magalhes J 2002Endocr Pathol2002,13,4:1
15Solubilization of waste-activated sludge by ultrasonic treatment显示文摘Bougrier C Carr'ere H Delgen'es J P 2005Chemical Engineering Journal2005,,106:1
16Efficacy of electrical stimulation to increase muscle strength in people with neurological conditions : A systematic review 显示文摘Glinsky J Harvey L van Es P 2007Physiother Res Int2007,12,3:1
17Influence of humic substances on the photolysis of aqueous pesticide residues显示文摘GARBIN J R DE'BORA M B P MILORI Sim(O)es M L 2007Chemosphere2007,66,:1
18The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinos-itol 4,5-bisphosphate in plasma membranes显示文摘Lim J Yusoff P Wong ES et 01 2002Mol Cell Biol2002,22,22:1
19Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis 显示文摘Van Es M A Schelhaas H J Van Vught P W 2011Ann Neurol2011,70,6:1
20New forms of local governance: A theoretical and empirical analysis of municipal corporations in Portugal显示文摘Tavares A F Cam?es P J 2010Public management review2010,12,5:1
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