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| 1 | Help, hope and hype: ethical considerations of human microbiome research and applications显示文摘 | Yonghui Ma Hua Chen Canhui Lan Jianlin Ren | 2018 | Protein & Cell2018，9，5： | 6 |
| 2 | Construction of homozygous diploid potato through maternal haploid induction显示文摘Reinventing the tetraploid potato into a seed-propagated,diploid,hybrid potato would significantly accelerate potato breeding.In this regard,the development of highly homozygous inbred lines is a prerequisite for breeding hybrid potatoes,but self-incompatibility and inbreeding depression present challenges for developing pure inbred lines.To resolve this impediment,we developed a doubled haploid(DH)technology,based on mutagenesis of the potato DOMAIN OF UNKNOWN FUNCTION 679 membrane protein(StDMP)gene.Here,we show that a deficiency in StDMP allows the generation of maternal haploids for generating diploid potato lines.An exercisable protocol,involving hybridization,fluorescent marker screening,molecular and flow cytometric identification,and doubling with colchicine generates nearly 100%homozygous diploid potato lines.This dmp-triggered haploid induction(HI)system greatly shortens the breeding process and offers a robust method for generating diploid potato inbred lines with high purity. | Jinzhe Zhang Jian Yin Jiayi Luo Die Tang Xijian Zhu Jie Wang Zhihong Liu Pei Wang Yu Zhong Chenxu Liu Canhui Li Shaojiang Chen Sanwen Huang | 2022 | aBIOTECH2022，3，3： | 2 |
| 3 | Finite Element Analysis of an Air Spring for Automobile Suspension显示文摘 | Yang Weimin Chen Canhui Chen Yaling | | 0，，01： | 1 |
| 4 | Finite Element Analysis of an Air Spring for Automobile Suspension显示文摘 | Yang Weimin Chen Canhui Chen Yaling | 2004 | Journal of Beijing University of Chemical Technology2004，，1： | 1 |
| 5 | Relationship between expression and prognostic ability of PTEN, STAT3and VEGF-C in colorectal cancer显示文摘 | Canhui Jin Aihong Wang Jianmin Chen Xiaomin Liu Gongping Wang | 2012 | Experimental and Therapeutic Medicine2012，，： | 1 |
| 6 | Finite element analysis of an air spring for automobile suspension显示文摘 | YANG Weimin CHEN Canhui CHEN Yaling | 2004 | Journal of Beijing University of Chemical Technology2004，31，3： | 1 |
| 7 | Engineering adjacent Fe_(3)C as proton-feeding centers to single Fe sites enabling boosted oxygen reduction reaction kinetics for robust Zn-air batteries at high current densities显示文摘Oxygen reduction reaction(ORR)plays an important role in the next-generation energy storage technologies,whereas it involves the sluggish and complicated proton-coupled electron transfer(PCET)steps that greatly limit the ORR kinetics.Therefore,it is urgent to construct an efficient catalyst that could simultaneously achieve the rapid oxygen-containing intermediates conversion and fast PCET process but remain challenging.Herein,the adjacent Fe_(3)C nanoparticles coupling with single Fe sites on the bubble-wrap-like porous N-doped carbon(Fe_(3)C@FeSA-NC)were deliberately constructed.Theoretical investigations reveal that the adjacent Fe_(3)C nanoparticles speed up the water dissociation and serve as proton-feeding centers for boosting the ORR kinetics of single Fe sites.Benefiting from the synergistic effect of the Fe_(3)C and single Fe sites,the Fe_(3)C@FeSA-NC affords an excellent half-wave potential of 0.88 V,and enables the assembled Zn-air batteries with the high peak power density of 164.5 mW·cm^(-2)and long-term stability of over 200 h at high current densities at 50 mA·cm^(-2).This work clarifies the mechanism for improving ORR kinetics of single atomic sites by engineering the adjacent proton-feeding centers,shedding light on the rational design of cost-effective electrocatalysts for energy conversion and storage technologies. | Canhui Zhang Xingkun Wang Kai Song Kaiyue Chen Shuixing Dai Huanlei Wang Minghua Huang | 2023 | Nano Research2023，16，7： | 1 |
| 8 | The role of extracellular matrix on unfavorable maternal-fetal interface:focusing on the function of collagen in human fertility显示文摘Extracellular matrix(ECM)is characterized as widespread,abundant,and pluripotent.Among ECM members,collagen is widely accepted as one of the most prominent components for its essential structural property that can provide a scaffold for other components of ECM and the rich biological functions,which has been extensively used in tissue engineering.Emerging evidence has shown that the balance of ECM degradation and remodeling is vital to regulations of maternal-fetal interface including menstrual cycling,decidualization,embryo implantation and pregnancy maintenance.Moreover,disorders in these events may eventually lead to failure of pregnancy.Although the improvement of assisted conception and embryo culture technologies bring hope to many infertile couples,some unfavorable outcomes,such as recurrent implantation failure(RIF),recurrent pregnancy loss(RPL)or recurrent miscarriage(RM),keep troubling the clinicians and patients.Recently,in vitro three-dimensional(3D)model mimicking the microenvironment of the maternal-fetal interface is developed to investigate the physiological and pathological conditions of conception and pregnancy.The progress of this technology is based on clarifying the role of ECM in the endometrium and the interaction between endometrium and conceptus.Focusing on collagen,the present review summarized the degradation and regulation of ECM and its role in normal menstruation,endometrium receptivity and unsatisfying events occurring in infertility treatments,as well as the application in therapeutic approaches to improve pregnancy outcomes.More investigations about ECM focusing on the maternal-fetal interface interaction with mesenchymal stem cells or local immunoregulation may inspire new thoughts and advancements in the clinical application of infertility treatments. | Rang Liu Mengyuan Dai Guidong Gong Mei Chen Canhui Cao Tianren Wang Zhenhui Hou Yu Shi Junling Guo Yaoyao Zhang Xi Xia | 2022 | Journal of Leather Science and Engineering2022，4，1： | 0 |
| 9 | Structural characteristics and biological functions of the HIV-1 gp120 V3 region显示文摘Recent studies demonstrate that the V3 loop of HIV-1 gp120 plays an important role in the attachment of HIV-1 to the target cells. Several amino acids in this domain are involved in the interaction of gp120 with the co-receptors. The V3 loop elicits one of the earliest antiviral antibody responses in HIV-1 infection and has been identified as the principal neutralizing determinant (PND). A subset of antibodies to V3 loop show a broad range of neutralizing activity. Unfortunately, this loop undergoes broad mutation and is one of the hypervariable regions. Mutations of some amino acids in this PND could affect syncytium formation, virus infectivity and neutralization. Knowing the structural characteristics and biological functions of the V3 region could help us to understand mechanism of HIV infection and to develop new strategy against HIV-1. In this review, the structural characteristics, variation and biological functions of the V3 loop as well as immunological responses to the V3 loop are discussed. | TIAN Haijun, LAN Canhui, JIANG Shibo2 and CHEN Yinghua(1. Laboratory of Immunology, Department of Biological Science and Biotechnology, Tsinghua University Protein Science Laboratory of the Ministry of Education, Beijing 100084, China 2. LindsleyF. Kimball Research Institute, New York Blood Center, USA) | 2002 | Progress in Natural Science:Materials International2002，12，11： | 0 |
| 10 | Evidence for existence of a close association between CD14 and CXCR4 on monocytic cell line U937显示文摘单核白血球上的 HIV-1 coreceptors (CXCR4 和 CCR5 ) 的表面表示能被房间的 CD14,和危险性的 ligand 调整到 HIV-1 然后被改变。我们的以前的学习发现对 CD14 的那单音的同种细胞的抗体能戏剧性地禁止药物治疗 CXCR4 的趋化性和房间房间熔化。把研究基于这些,我们在结合 lineFITC 的 anti-CD14 monocolnal 抗体(mAb ) 12G5 强烈禁止了的 monocytic 房间上探索了在 CD14 和 CXCR4 之间的潜在的关系结合 FITC 的 anti-CD14 有约束力单音的同种细胞的抗体(TUK4 和 UCHM1 ) 到 U937,当另一 CX-CR4-specific mAb B-R24 没在这绑定上显示出任何效果时。在另一方面,二 anti-CD14 单音的同种细胞的抗体(TK4 和 UCH-M1 ) 显然禁止了结合 PE 的 anti-CXCR4 mAb 12G5 的绑定到 U937 但是没禁止 mAb 12G5 的绑定到 CXCR4-transfected 3T3 房间(3T3。T4, CXCR4 ) ,它显示由 CD14 特定的 mAbs 堵住对 CXCR4 有约束力的 mAb 12G5 不涉及可能性那 CD14 特定的 mAbs 直接绑在 CXCR4。这些结果在 monocytic 房间线 U937 上建议了在 CD14 和 CXCR4 之间的一个靠近的协会的存在。 | Yang Hengwen Lan Canhui Chen Yinghua | 2007 | Progress in Natural Science:Materials International2007，17，8： | 0 |
| 11 | Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones(Cannabis sativa L.)显示文摘We investigated the effect of iron oxide nanoparticles(Fe_(3)O_(4)NPs,~17 nm in size)on the phenotype and metabolite changes in hemp(Cannabis sativa L.),an annual crop distributed worldwide.Hemp clones were grown in hydroponic cultures with Fe_(3)O_(4)NPs(50,100,200,or 500 mg/L)for four weeks.TEM and ICP-MS were used to determine Fe_(3)O_(4)NPs uptake and translocation.LC-MS-based metabolomics was employed to explore the deep insight into the effect of Fe_(3)O_(4)NPs on hemp plants.The results revealed that plant growth enhanced gradually with increasing concentrations of given NPs up to 200 mg/L,which improved the fresh weight and dry weight by 36.13%and 74.68%,respectively,compared to the control.Even at a high dose(500 mg/L),Fe_(3)O_(4)NPs promoted plant growth,including increased biomass and tissue length.NPs significantly increased the iron and chlorophyll content in plant tissues Increased catalase activity and reduced hydrogen peroxide content in hemp leaves suggested that the Fe_(3)O_(4)NPs activated the defense system.TEM showed that NPs were abundantly attached to the cell wall and dispersed throughout the root cells.Metabolomics revealed that Fe_(3)O_(4)NPs induced metabolic reprogramming in hemp leaves,including the up-regulation of carbohydrates and organic acids,and down-regulation of antioxidants,especially tetrahydrocannabinol(THC).The significantly up-regulated metabolites,including peonidin and 2-hydroxycinnamic acid,could be involved in photosynthesis in hemp plants.These results demonstrate the potential of Fe_(3)O_(4)NPs for promoting hemp growth and decreasing the THC content at low doses. | Canhui Deng Qing Tang Zemao Yang Zhigang Dai Chaohua Cheng Ying Xu Xiaojun Chen Xiaoyu Zhang Jianguang Su | 2022 | Frontiers of Environmental Science & Engineering2022，16，10： | 0 |
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