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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | The Geochemical and Zircon Trace Elements Characteristics of A-type Granitoids in Boziguoer, Baicheng County, Xinjiang显示文摘The Boziguoer A-type granitoids in Baicheng County,Xinjiang,belong to the northern margin of the Tarim platform as well as the neighboring EW-oriented alkaline intrusive rocks.The rocks comprise an aegirine or arfvedsonite quartz alkali feldspar syenite,an aegirine or arfvedsonite alkali feldspar granite,and a biotite alkali feldspar syenite.The major rock-forming minerals are albite,K-feldspar,quartz,arfvedsonite,aegirine,and siderophyllite.The accessory minerals are mainly zircon,pyrochlore,thorite,fluorite,monazite,bastnaesite,xenotime,and astrophyllite.The chemical composition of the alkaline granitoids show that SiO2varies from 64.55%to 72.29%with a mean value of 67.32%,Na2O+K2O is high(9.85%–11.87%)with a mean of 11.14%,K2O is 2.39%–5.47%(mean=4.73%),the K2O/Na2O ratios are 0.31–0.96,Al2O3ranges from 12.58%to 15.44%,and total FeO T is between 2.35%and 5.65%.CaO,MgO,MnO,and TiO2are low.The REE content is high and the total SREE is(263–1219)ppm(mean=776 ppm),showing LREE enrichment and HREE depletion with strong negative Eu anomalies.In addition,the chondrite-normalized REE patterns of the alkaline granitoids belong to the'seagull'pattern of the right-type.The Zr content is(113–1246)ppm(mean=594 ppm),Zr+Nb+Ce+Y is between(478–2203)ppm with a mean of 1362 ppm.Furthermore,the alkaline granitoids have high HFSE(Ga,Nb,Ta,Zr,and Hf)content and low LILE(Ba,K,and Sr)content.The Nb/Ta ratio varies from 7.23 to 32.59(mean=16.59)and the Zr/Hf ratio is 16.69–58.04(mean=36.80).The zircons are depleted in LREE and enriched in HREE.The chondrite-normalized REE patterns of the zircons are of the'seagull'pattern of the left-inclined type with strong negative Eu anomaly and without a Ce anomaly.The Boziguoer A-type granitoids share similar features with A1-type granites.The average temperature of the granitic magma was estimated at 832–839°C.The Boziguoer A-type granitoids show crust–mantle mixing and may have formed in an anorogenic intraplate tectonic setting under high-temperature,anhydrous,and low oxygen fugacity conditions. | LIU Chunhua YIN Jingwu WU Cailai SHAO Xingkun YANG Haitao XU Haiming WANG Jun | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 2 |
| 3 | Engineering core–shell Co_(9)S_(8)/Co nanoparticles on reduced graphene oxide: Efficient bifunctional Mott–Schottky electrocatalysts in neutral rechargeable Zn–Air batteries显示文摘It is significant for the rational construction of the high–efficient bifunctional electrocatalysts for in–depth understandings of how to improve the electron transfer and ion/oxygen transport in catalyzing oxygen reduction reaction and oxygen evolution reaction(ORR and OER),but still full of vital challenges.Herein,we synthesize the novel“three–in–one”catalyst that engineers core–shell Mott–Schottky Co_(9)S_(8)/Co heterostructure on the defective reduced graphene oxide(Co_(9)S_(8)/Co–rGO).The Co_(9)S_(8)/Co–rGO catalyst exhibits abundant Mott–Schottky heterogeneous–interfaces,the well–defined core–shell nanostructure as well as the defective carbon architecture,which provide the multiple guarantees for enhancing the electron transfer and ion/oxygen transport,thus boosting the catalytic ORR and OER activities in neutral electrolyte.As expected,the integrated core–shell Mott–Schottky Co_(9)S_(8)/Co–rGO catalyst delivers the most robust and efficient rechargeable ZABs performance in neutral solution electrolytes accompanied with a power density of 59.5 mW cm^(-2) and superior cycling stability at 5 mA cm^(-2) over 200 h.This work not only emphasizes the rational designing of the high–efficient bifunctional oxygen catalysts from the fundamental understanding of accelerating the electron transfer and ion/oxygen transport,but also sheds light on the practical application prospects in more friendly environmentally neutral rechargeable ZABs. | Xingkun Wang Guangming Zhan Yurou Wang Yan Zhang Jian Zhou Ren Xu Huiyu Gai Huanlei Wang Heqing Jiang Minghua Huang | 2022 | Journal of Energy Chemistry2022，31，5： | 2 |
| 4 | Coupling of NiFe-Based Metal-Organic Framework Nanosheet Arrays with Embedded Fe-Ni_(3)S_(2) Clusters as Efficient Bifunctional Electrocatalysts for Overall Water Splitting显示文摘Developing highly efficient,easy-to-make and cost-effective bifunctional electrocatalysts for water splitting with lower cell voltages is crucial to producing massive hydrogen fuel.In response,the coupled hierarchical Ni/Fe-based MOF nanosheet arrays with embedded metal sulfide nanoclusters onto nickel foam skeleton(denoted as Fe-Ni_(3)S_(2)@NiFe-MOF/NF)are fabricated,in which the Fe-Ni_(3)S_(2) clusters could effectively restrain the aggregation of the layer metal-organic frameworks(MOF)nanosheets and adjust the local electronic structures of MOFs nanosheets.Benefiting from the rapid charge transfer and the exposure of abundant active sites,the well-designed Fe-Ni_(3)S_(2)@NiFe-MOF/NF displays excellent oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)performance.More importantly,when equipped in the alkaline water electrolyzer,the Fe-Ni_(3)S_(2)@Ni Fe-MOF/NF enables the system with a mere 1.6 V for achieving the current density of 10 mA cm^(-2).This work offers a paradigm for designing efficient bifunctional HER/OER electrocatalysts based on the hybrid materials of nanostructured metal sulfide and MOF. | Xianbiao Hou Tianyuan Jiang Xiujuan Xu Xingkun Wang Jian Zhou Huimin Xie Zhicheng Liu Lei Chu Minghua Huang | 2022 | Chinese Journal of Structural Chemistry2022，41，7： | 1 |
| 5 | Engineering adjacent Fe_(3)C as proton-feeding centers to single Fe sites enabling boosted oxygen reduction reaction kinetics for robust Zn-air batteries at high current densities显示文摘Oxygen reduction reaction(ORR)plays an important role in the next-generation energy storage technologies,whereas it involves the sluggish and complicated proton-coupled electron transfer(PCET)steps that greatly limit the ORR kinetics.Therefore,it is urgent to construct an efficient catalyst that could simultaneously achieve the rapid oxygen-containing intermediates conversion and fast PCET process but remain challenging.Herein,the adjacent Fe_(3)C nanoparticles coupling with single Fe sites on the bubble-wrap-like porous N-doped carbon(Fe_(3)C@FeSA-NC)were deliberately constructed.Theoretical investigations reveal that the adjacent Fe_(3)C nanoparticles speed up the water dissociation and serve as proton-feeding centers for boosting the ORR kinetics of single Fe sites.Benefiting from the synergistic effect of the Fe_(3)C and single Fe sites,the Fe_(3)C@FeSA-NC affords an excellent half-wave potential of 0.88 V,and enables the assembled Zn-air batteries with the high peak power density of 164.5 mW·cm^(-2)and long-term stability of over 200 h at high current densities at 50 mA·cm^(-2).This work clarifies the mechanism for improving ORR kinetics of single atomic sites by engineering the adjacent proton-feeding centers,shedding light on the rational design of cost-effective electrocatalysts for energy conversion and storage technologies. | Canhui Zhang Xingkun Wang Kai Song Kaiyue Chen Shuixing Dai Huanlei Wang Minghua Huang | 2023 | Nano Research2023，16，7： | 1 |
| 6 | Tracing the formation of oxygen vacancies at the conductive LaAlO3/SrTiO3 interface via photoemission显示文摘The two-dimensional electron gas(2DEG)generated at the LaAlO3/SrTiO3 interface has been in the focus of oxides re-search since its first discovery.Although oxygen vacancies play an important role in the generation of the insulator-to-metal transition of the SrTiO3 bare surface,their contribution at the LaAlO3/SrTiO3 interface remains unclear.In this work,we investigated a LaAlO3/SrTiO3 heterostructure with regional distribution of defect-based localized polar sites at the interface.Using static and time-resolved threshold photoemission electron microscopy,we prove that oxygen vacan-cies are induced near those polar sites,resulting in the increase of carrier density of the 2DEG states.In addition,oxy-gen-related surface states were uncovered,which we attributed to the release of lattice oxygen during the formation of oxygen vacancies.Such effects are mainly found spatially located around the defect sites at the buried interface,while other regions remain unaffected.Our results confirm that the itinerant electrons induced by oxygen vacancies can coex-ist with the charge transfer mechanism in the LaAlO3/SrTiO3 heterostructure,together leading to the formation of the metallic interface.These observations provide fundamental insights into the nature of LaAlO3/SrTiO3 interface based 2DEG and unique perspectives for potential applications. | Junyan Chen Tobias Eul Lu Lyu Yaolong Li Xiaoyong Hu Xingkun Ning Shufang Wang Martin Aeschlimann Qihuang Gong | 2022 | Opto-Electronic Science2022，1，7： | 1 |
| 7 | Nanoengineering of brucite@SiO 2for enhanced mechanical properties and flame retardant behaviors显示文摘 | Pang Hongchang Wang Xuesong Zhu Xingkun | 2015 | Polymer Degradation and Stability2015，120，： | 1 |
| 8 | Simulation of AMT autoshift process based on Matlab/Simulink/Stateflow 显示文摘 | Wang Yuhai Song Jian Li Xingkun | 2004 | SAE Paper2004，，： | 1 |
| 9 | Ubiquitination and degradation of SIK2 by DNA-PKcs deficiency promote radiation-induced mitotic catastrophe显示文摘Salt-inducible kinase 2 (SIK2) is a member of the AMP-activated serine/threonine kinase family. It has been reported that inhibition of SIK2 can enhance the cytotoxicity of paclitaxel,1 promote premitotic apoptosis, and lead to cell cycle arrest in the metaphase.2 Thus, targeting SIK2 may be a therapeutic strategy for cancers drug and radiotherapy resistance. Mitotic catastrophe is a type of abnormal mitosis leading to cell death characterized by the multipolar spindle and multinucleation, which was first discovered during an ionizing radiation (IR)-induced cell damage.3 However, the mechanism of mitotic catastrophe is not well understood. The present study aimed to assess the effect of the knockdown of SIK2 on IR-induced mitotic catastrophe. | Jiaojiao Zhu Ying Zhang Ziyan Yan Jianxiao Wang Ping Wang Xinxin Liang Yuhao Liu Xingkun Ao Maoxiang Zhu Pingkun Zhou Yongqing Gu | 2023 | Genes & Diseases2023，10，2： | 0 |
| 10 | Synthesis of hierarchical transition metal oxyhydroxides in aqueous solution at ambient temperature and their application as OER electrocatalysts显示文摘First-row(3 d)transition metal oxyhydroxides have attracted increasing attention due to their various advantages.Although investigating the oxidation mechanism and processing such materials into hierarchical architectures are greatly desired for their further development,it remains unclear how the oxidation state change occurs,and efforts to produce hierarchical oxyhydroxides in compliance with high ecological and economic standards have progressed slowly.Here,we describe a facile one-step coprecipitation route for the preparation of hierarchical CoOOH,NiOOH and MnOOH,which involves the diffusion of NH_(3)originating from ammonium hydroxide solution into an aqueous solution containing metal ion salts and K_(2)S_(2)O_(8).Comprehensive characterizations by scanning electron microscope,transmission electron microscopy,X-ray diffraction analysis,X-ray photoelectron spectroscopy,ultraviolet-visible spectroscopy and in situ p H measurement demonstrated that K_(2)S_(2)O_(8)induces the oxidation state change of metal ion species after the start of hydrolysis.Meanwhile,it was found that,benefiting from the OH–concentration gradient created by the NH_(3)diffusion method and the suitable growth environment provided by the presence of K_(2)S_(2)O_(8)(high nucleation rate and secondary nucleation),the formation of hierarchical oxyhydroxide structures can be realized in aqueous solution at ambient temperature without the use of heat energy and additional structure-directing agents.The hierarchical CoOOH structures are performed as the electrocatalysts for the oxygen evolution reaction in alkaline media,which exhibit good activity with an overpotential of 320 m V at 10 m A cm^(-2)and a low Tafel slope of 59.6 m V dec^(–1),outperforming many congeneric electrocatalysts.Overall,our study not only provides important insights to understand the formation mechanism of hierarchical oxyhydroxides,but also opens up new opportunities for the preparation of hierarchical oxyhydroxides via a facile,green and low-cost method. | Zongkun Chen Xingkun Wang Sascha Keßler Qiqi Fan Minghua Huang Helmut Cölfen | 2022 | Journal of Energy Chemistry2022，31，8： | 0 |
| 11 | BRIEF COMMUNICATION ARISING Geng et al.reply显示文摘The accompanying comment by Dr.Rao,suggests that there is an omission of citation of 12 previous publications in our Wang et al.paper.1 We disagree with the suggestion for the following reasons.We believe that the 12 publications cited by Dr.Rao do not have sufficient relevance to the Wang et al.paper.1 The past decades have witnessed an explosive growth in our understanding of the pathogenesis of Alzheimer's disease(AD),which is a very complicated process.The Wang et al. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2020 | Cell Research2020，30，9： | 0 |
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