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| 1 | A new long-acting GLP-1 derivative KTP ameliorates hyperglycemia and dyslipidemia and improves pancreas and fatty liver in db/db mice显示文摘Glucagon-like peptide-1 (GLP-1) is a polypeptide incretin hormone that glucose-dependently promotes the secretion and synthesis of insulin. However, its half-life is extremely short. To enhance its half-life, we developed a long-acting GLP-1 derivative KTP with controlled release, designed on the basis of another GLP-1 derivative GP62. The kinetics and bioactivity of KTP were evaluated in Sprague Dawley (SD) rats. Long-term treatment of KTP was performed in db/db mice. Mice were treated twice daily with subcutaneous injections of KTP (1.2 mg/kg body weight), Exendin-4 (0.1 mg/kg body weight) or vehicle (phosphate buffered saline (PBS), pH 7.4) for 60 d. KTP had a longer half-life, as well as further increasing the secretion and production of insulin and reducing blood glucose concentrations, than GP62. Long-term treatment with KTP also induced anorexia, decreased water and food intake, decreased weight gain, improved blood glucose and blood lipid and ameliorated pancreatic damage and fatty liver in db/db mice. | SANG YanXia ZHOU TianHong LI HongJian RAN YanHong JIANG DeQi ZHENG Fei CHEN Ying WANG CongFeng ZOU Xin | 2013 | Chinese Science Bulletin2013，58，20： | 2 |
| 2 | Fuzzy set theories and methods for municipal environmental quality assessment显示文摘 | | 1995 | The Journal of Fuzzy Mathematics (USA)1995，3，1： | 1 |
| 3 | Degradation of 4-chlorophenol in a dielectric barrier discharge system显示文摘 | Xihua Chen Wenjuan Bian Xuehong Song Deqi Liu Jiao Zhang | 2013 | Separation and Purification Technology2013，，： | 1 |
| 4 | Numerical simulation of a thermal-bubble actuated diffuser-nozzle valveless pump显示文摘A valveless micropump actuated by thermal bubbles which are generated by an electrode heater mounted with a pair of diffuser nozzles has been numerically studied by commercial CFD software FLUENT. The relationships between the net flow rate and the superheating and heat supplying frequency have been investigated. The depth of the diffuser-nozzle micropump is 200 μm, the diameter of the actuating chamber is 1 mm, and a pair of diffuser nozzles whose gap has been expanded from 30 μm to 274 μm with an open angle of 7° are connected to the actuating chamber. The working fluid is methanol. In the numerical simulation, the flow pattern is laminar. The results show that the pump has different optimal driving frequencies at different superheating. A cycle resulting from bubble growth and shrinking costs more time at higher superheating temperature; different superheating has different optimal driving frequency; when the superheating increases, the maximum volume flow rate and the maximum pump pressure will increase simultaneously, and the optimal driving frequency decreases as well, the maximum volume flow rate and pump pressure also have the same tendency; in the condition of uncontrolled condensing, the bubble shrinking process is longer than the growth process, thus it is the determining factor to affect the pump performance. The maximum volume flow rate is 9.02 μL/min at △T = 15℃, and the maximum pump pressure is 680 Pa. With the increase of wall superheat, cycle including the bubble growth and condensation will become longer, resulting in a significant impact on the pumping flow; different wall superheat has different optimized frequency, increasing superheat will bring increased pumping flow and pump pressure, the optimized driving frequency will be reduced; liquid supply phase is longer than pumping phase. | PAN LiangMing DENG JieWen YUAN DeWen CHEN DeQi ZHANG JunQi | 2009 | Science China(Technological Sciences)2009，52，10： | 1 |
| 5 | Experiment Investigation and Control Strategies on Two-Phase Refrigerant Injection Heat Pump System for Electric Vehicle in Start-up Stage显示文摘Due to the poor heating performance and operating safety in low ambient temperature,traditional Air Source Heat Pump(ASHP)for Electric Vehicles(EVs)has many limits in cold region,which can be solved by the ASHP with refrigerant injection.During the start-up stage of EV in winter,the inlet air temperature of the in-car condenser is the same as the ambient temperature.At this situation,the performance and control strategy of the heat pump require special attention.In the present study,a series of experiments were carried out on the heating performance of the Refrigerant Injection Heat Pump(RIHP)system in start-up stage of EV,at the ambient temperature from–20℃ to–5℃.The effects of compressor speed and injected refrigerant state on the heating performance of the system were discussed in depth.According to the results,the control strategies during start-up stage have been discussed in the end of the article.The study provides a practical control strategy for the RIHP system during the start-up stage of electric vehicles,helping to efficiently operate electric vehicles in cold regions. | QIN Fei LIU Hanzhou ZOU Huiming CHEN Deqi TIAN Changqing | 2021 | Journal of Thermal Science2021，30，3： | 1 |
| 6 | Improved flame resistance properties of unsaturated polyester resin with TiO2-MXOY solid superacid显示文摘Five SO4^2-/TiO2-MXOY solid super acids(SSA:Cu@Ti:SSA,Zr@Ti:SSA,Fe@Ti:SSA,Mn@Ti:SSA,Mo@Ti:SSA)were successfully prepared by sol-gel method,and its chemical structure and element content were characterized by X-ray diffraction(XRD)analysis,Fourier transform infrared spectroscopy(FHIR)and energy dispersive spectroscopy(EDS).Then,a compound flame retardant system containing SSA and ammonium polyphosphate/montmorillonite(AM)were was introduced into an unsaturated polyester resin(UPR)to enhance the flame retardance.The effect of SSA on the flammability and thermal stability of the UPR was evaluated by the limiting oxygen index(LOI),cone calorimeter te st(CCT)and thermogravimetric analysis(TGA).The LOI results showed that the flame retardance of the UPR composites was significantly improved with the addition of SSA.Moreover,their heat release rate(HRR),total heat release(THR),the smoke production rate(SPR)and CO and CO2 yield were much decreased.In addition,the initial decomposition temperature of UPR/AM/S SA was delayed,indicating that their thermal stability was increased,and the residual char of UPR/AM/SSA was also increa sed due to strong catalytic of SSA ability for esterification and dehydration.Furthermore,the microstructure of the residual char after combustion of the UPR composites was studied by the scanning electron microscopy(SEM),and it was found that the char layer structure was more continuous and dense after the addition of the SSA.In sum up,the synergistic effect between SSA and AM was the main factor for the great improvement of flame retardant of UPR composites. | Xuexi Chen Mei Wan Ming Gao Yanxia Wang Deqi Yi | 2020 | Chinese Journal of Chemical Engineering2020，28，9： | 0 |
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