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| 1 | A single center investigation of bare-metal or drug-eluting stent restenosis from 1633 consecutive Chinese Han ethnic patients显示文摘Background Stents are widely used in China but the clinical impression is somehow that restenosis is less common because of the lower prevalence of coronary artery disease (CAD) and associated risk factors in Chinese populations. However, no large-sample published studies are available on angiographic stent restenosis including those of bare-metal stent (BMS) or drug-eluting stent (DES) in Chinese Han ethnic population. Mothods A total of 1633 consecutive patients with CAD who had undergone coronary stenting, quantitative coronary angiography (QCA) were retrospectively studied. At the time of stent implantation and at 7 months post-stenting 675 patients had a follow-up angiography. Statistical analysis was made with the chi-square test for categorical variables, unpaired t test for continuous variables, univariate or multivariate regression for baseline and angiographic characteristics and the Kaplan-Meier method for rate of target lesion revascularization (TLR). Results Stent restenosis was defined as ≥50% diameter stenosis in the dilated segment. A total of 675 patients with 1074 lesions were subjected to angiographic follow-up for 7 months on average. Of these lesions, 448 were implanted with BMS whereas 626 lesions with DES. At 7 months, bare-metal in-stent restenosis occured in 148 lesions (33.0%), and bare metal in-segment restenosis in 155 lesions (34.6%) in contrast to drug-eluting in-stent restenosis in 48 lesions (7.7%) and drug-eluting in-segment restenosis in 73 lesions (11.7%) (P<0.001 compared with BMS respectively). Late loss in both in-stent and in segment was higher in BMS than in DES groups [(1.00±0.69) vs (0.28±0.52); (0.78±0.71) vs (0.21±0.52), P<0.001 respectively]. Angulated lesion, lesion length, pre-procedural minimal luminal diameter (MLD), and BMS were independent predictors for TLR, (P<0.01 respectively), whereas current smoker, ostial lesion, and stent overlapping, post-procedure in-stent MLD, lesion length, and stent types were independent predictors for in-segment restenosis (P<0.01 respectively). Standard coronary risk factors such as hypertension, hyperlipidemia, diabetes, and history of CAD were not associated with a higher rate of restenosis caused by BMS or DES implantation in our Chinese Han ethnic population. Conclusions Coronary stenting including BMS or DES implantation in Chinese Han ethnic patients is associated with a restenosis rate comparable to that demonstrated in previous studies from the western countries, and predictors of stent restenosis are somehow different from those in the western population. | XU Bo LI Jian-jun YANG Yue-jin MA Wei-hua CHEN Ji-lin QIAO Shu-bin QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2006 | Chinese Medical Journal2006，，7： | 23 |
| 2 | A randomized comparative study of using enoxaparin instead of unfractionated heparin in the intervention treatment of coronary heart disease显示文摘Background Low molecular weight heparin (LMWH) was more effective than unfractionated heparin (UFH) in treating acute coronary syndrome (ACS). However, it remains uncertain whether LMWH can be used in patients undergoing percutaneous coronary intervention (PCI) instead of UFH. This study aimed to evaluate the efficacy and safety of using enoxaparin instead of UFH in the intervention treatment of patients with coronary heart disease (CHD) Methods From October 2003 to Febuary 2005, 966 patients with CHD were enrolled into this study. Among 966 patients, 455 patients received the PCI, including 283 patients with Non-ST segment elevation ACS (NSTEACS), 511 patients did not received PCI due to mild, moderate lesions or were suitable for coronary artery bypass graft (CABG). The 966 patients were randomized to enoxaparin group (484 patients) and UFH group (482 patients). Patients in the enoxaparin group were given enoxaparin at least twice subcutaneously (1 mg/kg,q12 h) before catheterization. Plasma anti-Xa activity was determined 1-8 hours after the last dose of enoxaparin was determined. The catheterization was performed within 8 hours after the last dose of enoxaparin. The sheath was removed immediately after the procedure. Patients in the UFH group were given UFH 25 mg intravenously before coronary angiography. Additional 65 mg was given intravenously if PCI was to be performed. The sheath was removed 4 hours after the procedure. Results A total of 227 patients in the enoxaparin group and 228 patients in the UFH group received PCI. In the enoxaparin group,one patient developed acute thrombosis during PCI and resulted in acute myocardial infarction (AMI), no acute or subacute thrombosis was found during hospitalization. In the UFH group, no acute or subacute thrombosis occurred during PCI procedure and hospitalization. Therefore, the incidence of major adverse cardiovascular events (MACEs) during the hospitalization was 0.44% in the enoxaparin group and 0 in the UFH group. In the enoxaparin group, the sheath was removed immediately after the procedure and 8 patients had hematoma on the puncture site. In the UFH group, the sheath was removed 4 hours after the procedure and 20 cases had hematoma on the puncture site. The incidence of hematoma on the puncture site was significantly higher in the UFH group than that in the enoxaparin group (P<0.05). Anti-Xa activity was determined in 174 patients in LMWH group. The mean anti-Xa activity was (0.87±0.23) U/ml, and 94.8% of them had anti-Xa activity >0.5 U/ml and 6.9% of the patient >1.2 U/ml. There was no death and AMI occurred in enoxaparin group, but one patient had AMI caused by subacute thrombosis in UFH group during 30-day follow-up. MACE rate at 30-day follow-up was 0 in enoxaparin group and 0.43% in UFH group. Conclusions The results of the study suggest that it is safe and efficient to give enoxaparin at least twice beforethe PCI procedure, and the sheath can be removed immediately after PCI. For NSTEACS patient who has received enoxaparin more than twice during the hospitalization can undergo PCI directly and no UFH is necessary before or during PCI. | CHEN Ji-lin CHEN Jue QIAO Shu-bin GUO Yuan-lin WU Yong-jian DAI Jun YUAN Jin-qing QIN Xue-wen YANG Yue-jin GAO Run-lin | 2006 | Chinese Medical Journal2006，，5： | 19 |
| 3 | Angiographic prevalence of myocardial bridging in a defined very large number of Chinese patients with chest pain显示文摘背景:心肌内冠的动脉被称为的 epicardial 分割的肌纤维 overlying 心肌的衔接(MB ) 。MB 的可变流行与小、大的样品尺寸研究在尸体和 angiographic 系列被描述了。另外,没有类似的学习在中国人口被报导。这研究的目的是调查 MB 的 angiographic 流行在连续有从我们的中心的胸痛的 37,106 个中国病人。方法:我们进行了观察研究在经历的病人之中与 MB 评估连续案例选择冠的血管造影术,并且在很大的样品尺寸的这研究分析了 angiograhic 流行和 MB 的临床的特征。结果:在有胸痛的 37 105 个病人之中,我们以一种回顾的方式与 1011 MB 发现了 1002 个案例,并且全面流行是 2.70% 。尽管(991/1002 ) 超过 99% 病人有单个桥牌, 8 个案例被发现有超过二 MB (七与二,和一与三) 。没有动脉粥样硬化患者损害,总的来说 54.39% 案例(545/1002 ) 有 MB,并且(973/1011 )96.24% 在左前面的下降冠的动脉(男孩) 衔接定位了,主要在男孩的中间(792/1011, 78.33%) 。根据诺贝尔分类,单个桥(n=991 ) ,阻塞的 <50% 是占优势的(471/991, 47.52%) 。完全, 50%-69% 占了 34.81%(345/991 ) ,阻塞的 >70% 是 17.65%(175/991 ) 。结论:这些数据证明在有胸痛的中国病人的 angiographically 可检测的 MB 的流行类似于以前的研究的那些,与在这种很大的样品尺寸的 2.7% 流行。 | LI Jian-jun SHANG Zheng-lu YAO Min LI Jie YANG Yue-jin CHEN Ji-lin QIAO Shu-bin MA Wei-hua QIN Xue-wen LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XU Bo XIA Ran GAO Run-lin | 2008 | Chinese Medical Journal2008，，5： | 17 |
| 4 | Role of plasma C-reactive protein in predicting in-stent restenosis in patients with stable angina after coronary stenting显示文摘背景血浆的角色高敏感在 in-stent 狭窄(ISR ) 的 C 反应的蛋白质(hs-CRP ) 仍然保持争论。我们在成功的冠的 stenting 以后与稳定的咽峡炎( SA )在病人在承认和后续调查了血浆 hs-CRP 水平以便为我们总结了的 ISR.Methods 澄清 hs-CRP 的预兆的价值有冠的 drug-eluting stent ( DES )的 303 个连续长期的 SA 病人 implantation.The ISR 被量的冠的分析分析( QCA )在一个平均数, 8 个月的后续,和病人作为 ISR 组( n=48 )和 non-ISR g 根据检测 ISR 被划分成二个组血浆 hs-CRP 在所有病人,在承认和 8 月的后续被检验在整个调查 period.Results QCA 继续的标准药介绍了那 48 个病人(15.8%) 在后续受不了 ISR。当血浆 hs-CRP 在在承认和后续的 non-ISR 组比那在 ISR 组是更高的时,基本临床的特征在二个组之间是类似的, P 0.001 分别地。 Multivariate 回归分析显示在承认或后续的那血浆 hs-CRP 水平能独立地预言 ISR 出现( OR=5.581 ,95% Cl 2.532-12.302 , P0.001and OR=6.299 ,95% CI 2.722-14.577 , P 0.001 ,分别地) .Conclusions 我们的数据显示那血浆 hs-CRP 水平可以独立地与冠的 DES 培植在 SA 病人在承认和后续预言 ISR ,它暗示长期的、持续全身的煽动性的回答可能涉及 ISR | XU Yan-lu LI Jian-jun XU Bo ZHU Cheng-gang YANG Yue-jin CHEN Ji-lin QIAO Shu-bin YUAN Jin-qing QIN Xue-wen MA Wei-hua YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2011 | Chinese Medical Journal2011，，6： | 17 |
| 5 | Increased plasma C-reactive protein level predicts rapid progression of non-target atherosclerotic lesions in patients with stable angina after stenting显示文摘背景尽管在预言动脉粥样硬化患者损害的快速的前进的 C 反应的蛋白质(CRP ) 的角色强烈地在不稳定的冠的动脉疾病被学习了,从有稳定的咽峡炎(SA ) 的病人的数据大部分是不在的。现在的学习评估了一个中间尺寸的耐心的队与 stent 培植和后续经历了经皮的冠的干预(一种总线标准)冠的 angiography ( CAG )并且测试了高度敏感的 CRP 的那增加的血浆水平将显示的假设 de novo 非目标的快速的前进在有 SA.Methods 的中国病人的冠的动脉损害学习人口与长期的 SA 311 个连续病人包括了在起始的承认上经历了冠的 stent | XU Yan-lu LI Jian-jun XU Bo ZHU Cheng-gang YANG Yue-jin CHEN Ji-lin QIAO Shu-bing YUAN Jin-qing QIN Xue-wen MA Wei-hua YAO Min LIU Hai-bo WU Yong-jian CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin | 2011 | Chinese Medical Journal2011，，19： | 17 |
| 6 | Comparing of Light Transmittance Aggregometry and Modified Thrombelastograph in Predicting Clinical Outcomes in Chinese Patients Undergoing Coronary Stenting with Clopidogrel显示文摘Background: Several platelet function tests are currently used to measure responsiveness to antiplatelet therapy. This study was to compare two tests, light transmittance aggregometry (LTA) and modified thrombelastography (mTEG), for predicting clinical outcomes in Chinese patients after percutaneous coronary intervention (PCI). Methods: Prospective, observational, single-center study of 789 Chinese patients undergoing PCI was enrolled. This study was investigated the correlations between the two tests and performed receiver operating characteristic curve (ROC) analysis for major adverse cardiovascular events (MACEs) at 1-year follow-up. Results: MACEs occurred in 32 patients (4.1%). Correlations were well between the two tests in the adenosine diphosphate induced platelet reactivity (Spearman r = 0.733, P 〈 0.001 ). ROC-curve analysis demonstrated that LTA (area under the curve [AUC]: 0.677; 95% confidence interval [CO: 0.643-0.710; P = 0.0009), and mTEG (AUC: 0.684; 95% CI: 0.650-0.716; P = 0.0001) had moderate ability to discriminate between patients with and without MACE. MACE occurred more frequently in patients with high on-treatment platelet reactivity (HPR) when assessed by LTA (7.4% vs. 2.7%; P 〈 0.001), and by TEG (6.7% vs. 2.6%; P 〈 0.001 ). Kaplan-Meier analysis demonstrated that HPR based on the LTA and mTEG was associated with almost 3-fold increased risk of MACE at 1-year follow-up. Conclusions: The correlation between LTA and mTEG is relatively high in Chinese patients. HPR measured by LTA and mTEG were significantly associated with MACE in Chinese patients undergoing PCI. | Xiao-Fang Tang Ya-Ling Han Jia-Hui Zhang Jing Wang Yin Zhang Bo Xu Zhan Gao Shu-Bin Qiao Jue Chen Yuan Wu Ji-Lin Chen Run-Lin Gao Yue-Jin Yang Jin-Qing Yuan | 2015 | Chinese Medical Journal2015，，6： | 16 |
| 7 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 8 | A comparison of clinical and angiographic outcomes after Excel bioabsorbable polymer versus Firebird durable polymer rapamycin-eluting stent for the treatment of coronary artery disease in a “real world” setting:six-month follow-up results显示文摘背景几临床的试用证明了 rapamycin-eluting stents 显著地在经皮的冠的干预(一种总线标准) 以后减少狭窄的风险。鲜艳的小鸟 stent 和 Excel stent (与 bioabsorbable 聚合物涂) rapamycin-eluting stents 的二种不同类型在中国被做,两个最近被州的食物药品管理局在中国为临床的使用同意了。然而,是否在在在2006年6月的每日的 practice.Methods 的 stents 的二种类型之间的安全和功效地有差别,是不清楚的, 190 个连续病人的一个总数专门与鲜艳的小鸟 stents 被对待( n=93 ,鲜艳的小鸟组)或胜过 stents ( n=97 ,胜过组)在我们的中心并且在这研究被包括。主要不利心脏的事件的频率(向,一死亡,心肌的梗塞或目标损害 revascularization 合成) ,二进制狭窄,和迟了的腔损失和 stent 血栓在二个 groups.Results 病人之间在一个六月的后续时期期间被比较,损害特征在这些组之间是可比较的。主要不利心脏的事件率在医院里并且在 6 个月是低的(2.1% 在 Excel 组织, 0% 在鲜艳的小鸟组织, P 0.05 ) 。6 月的 angiographic in-stent 狭窄率在两个组是 0% ,与联系迟了的损失(0.15 更高显著地在 PES 组织((0.14 ???????琠牨浯潢祬楳 吗?? | LIU Hai-bo XU Bo QIAO Shu-bin YANG Yue-jin MA Wei-hua QIN Xue-wen YAO Min WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran LI Jian-jun CHEN Ji-lin GAO Run-lin | 2007 | Chinese Medical Journal2007，，7： | 15 |
| 9 | Effects of coexisting polymorphisms of CYP2C19 and P2Y12 on clopidogrel responsiveness and clinical outcome in patients with acute coronary syndromes undergoing stent-based coronary intervention显示文摘 | TANG Xiao-fang ZHANG Jia-hui WANG Jing HAN Ya-ling XU Bo QIAO Shu-bin WU Yong-jian CHEN Jue WU Yuan CHEN Ji-lin GAO Run-lin YANG Yue-jin YUAN Jin-qing | 2013 | Chinese Medical Journal2013，，6： | 15 |
| 10 | Long-term clinical outcomes after bioabsorbable polymer- and durable polymer-based sirolimus-eluting stents implantation: two-year follow-up results from a large single-center database显示文摘背景几临床的试用证明了 sirolimus-eluting stents 显著地在经皮的冠的干预(一种总线标准) 以后减少狭窄的风险。鲜艳的小鸟 stent (与持久的聚合物涂) 并且 EXCEL stent (与 bioabsorbable 聚合物涂) sirolimus-eluting stents 的二种不同类型在中国被做;两个被州的食物药品管理局在中国为临床的使用同意了。期中考试(6 月) angiographic 和两 stents 的临床的结果被证实了使观点结果激动。然而,是否在在每日的 practice.Methods 的 stents 的二种类型之间的长期的安全和功效地有差别,是不清楚的经历选任的一种总线标准与的所有连续病人为佼佼者或在在在北京的 Fu Wai 医院的 6 月 1,2006 日和 2006 年 12 月 31 日之间的鲜艳的小鸟 stents 被包括。病人们根据 stent 类型从索引承认被分类(为佼佼者或鲜艳的小鸟) 使用。临床、程序的风险因素有希望地被收集。与倾向分数没有代替,匹配,主要不利心脏的事件的频率(向,一死亡,心肌的梗塞或目标容器 revascularization 合成)并且 stent 血栓在二 groups.Results 之间在一个2年的后续时期期间被比较 474 个病人的一个总数被对待与为佼佼者,并且 640 与鲜艳的小鸟被对待。 397 胜过病人被匹配到 397 个鲜艳的小鸟病人,2年的调整风险的向率是6.1%在胜过组,7.6%在鲜艳的小鸟组织( HR 0.84 , 95%CI 0.50-1.43 )而为死亡,心肌的梗塞和目标容器 revascularization 的各自的率是2.3%对2.8%(冷杉木 0.74 , 95%CI 0.30-0.85 ),1.8%对1.3%( HR 1.41,95%CI 0.45-4.43 )并且2.5%对4.0%( HR 0.62 , 95%CI 0.28-0.37 )分别地。在 2 年的 stent 血栓的累积发生在 EXCEL 组是1.8%对1.3%在 FIREBIRD 组织( P=0.5610 )而很迟了的 stent 血栓的率是0.5%对1.3%,( P=0.2550 ) .Conclusions 源于这种长期的、相对大的尺寸,单个中心的学习证明两个都, EXCEL 和 FIREBIRD , sirolimus-eluting stent 在每日的实践在一种总线标准以后有向的类似、更低的发生。 | LIU Hai-bo XU Bo YANG Yue-jin WANG Yang QIN Xue-wen YAO Min WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun MA Wei-hua LI Jian-jun QIAO Shu-bin CHEN Ji-lin LI Wei GAO Run-lin | 2009 | Chinese Medical Journal2009，，6： | 14 |
| 11 | THE COMPARATIVE STUDY OF EVENT RELATED POTENTIALSIN PATIENTS WITH OBSESSIVE COMPULSIVE DISORDER,DEPRESSION AND ANXIETY显示文摘Objective:To investigate the variations of contingent negative varisations(CNV),P300 and mismatch negativity (MMN) in patients with obsessive compulsive disorder(OCD),depressiopn and anxiety.MEthods:Event-related potentials CNV,P300 and MMN were recorded in 31 patients with OCD by Nicolet SPirit Instrument,and were compared with that of 20 depression controls(DC) and 17 anxiety controls(AC)and 28 normal controls(NC),Results:A significant difference of CNV among 4 sulbject groups was found in both post-imperative negative variation(PINV) and amplitudes(M1)(P<0.01)(emergence of PINV were 45%),60%,35%,and 4% in OCD,DC,AC and NC groups respectively),Compared with NC group,DC and AC groups showed decreased M1 amplitude(P<0.01).A significant difference of P300 among 4 groups was found in both latencies(Cz/N2) and P3 and nontarget-P2 amplitudes(P<0.05-0.01),The delayed MMN latencies of OCD and DC were similar to that of P300 changes,Conclusions:CNV,P300 and MMN are useful tools for assessing the brain malfunction of OCD,DC and AC,and its clinical application are suggested.The characteristics ERPs of those patients might be useful indexes in distinguishing OCD from DC and AC patients. | XIAO Zeping, CHEN Xingshi, ZHANG Mingdao , LOU Feiying, CHEN Jue Department of Psychophysiology, Shanghai Mental Health Center, Shanghai 200030, china. | 2003 | 现代电生理学杂志2003，10，1： | 14 |
| 12 | First report of a novel abluminal groove filled biodegradable polymer rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK trial显示文摘 | QIAN Jie XU Bo Alexandra J. Lansky YANG Yue-jin QIAO Shu-bin WU Yong-jian CHEN Jue HU Feng-huan YANG Wei-xian Gary S. Mintz Martin B. Leon GAO Run-lin | 2012 | Chinese Medical Journal2012，，6： | 14 |
| 13 | Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1显示文摘Brassinosteroids (BR ) 是在植物生长和开发有关键角色的必要类固醇荷尔蒙。BR 被房间表面察觉像受体的 kinase brassinosteroid 感觉迟钝 1 (BRI1 ) 。当 BR 不在时, BRI1 的 cytosolic kinase 领域(KD ) 被它的汽车禁止的 carboxyl 终点,以及由与禁止者蛋白质交往禁止, BRI1 kinase 禁止者 1 (BKI1 ) 。对 BRI1 的细胞外的域有约束力的 BR 怎么导致 BKI1 的 KD 和分离的激活进 cytosol,仍然保持不清楚。这里,我们报导在有交往的肽的建筑群的 BRI1 KD 的水晶结构源于 BKI1。我们也提供生物化学的证据那联系 BRI1 的 kinase (BAK1 ) 1 在开始 BR 发信号起一个必要作用。BRI1 和 BAK1 ectodomains 的类固醇依赖者 heterodimerization 为与 BKI1 和 transphosphorylation 竞争在正确取向带他们的细胞质的 KD。 | Jie Wang Jianjun Jiang Jue Wang Lei Chen Shi-Long Fan Jia-Wei Wu Xuelu Wang Zhi-Xin Wang | 2014 | Cell Research2014，24，11： | 12 |
| 14 | Impact of depressed left ventricular function on outcomes in patients with three-vessel coronary disease undergoing percutaneous coronary intervention显示文摘 | GAO Zhan XU Bo Ajay J. Kirtane YANG Yue-jin YUAN Jin-qing CHEN Ji-lin QIAO Shu-bin WU Yong-jian QIN Xue-wen YAN Hong-bin YAO Min LIU Hai-bo CHEN Jue YOU Shi-jie GAO Run-lin | 2013 | Chinese Medical Journal2013，，4： | 11 |
| 15 | Comparison of immediate and followup results between transradial and transfemoral approach for percutaneous coronary intervention in true bifurcational lesions显示文摘在为在分叉的经皮的冠的干预(一种总线标准) 的 transradial 和 transfemoral 途径之间的功效和安全的背景 A 比较没被做。这研究评估了 transradial 一种总线标准(TRI ) 的可行性并且在 bifurcations.Methods 把立即、紧跟的结果与 transfemoral 一种总线标准(TFI ) 作比较有分叉的 134 个连续病人从 2004 年 4 月在我们的医院里与打印机控制语言被对待到 2005 年 10 月。这些,在 TFI 组在 TRI 组和 74 个病人(101 损害) 有 60 个病人(88 损害) 。分叉类型根据因斯蒂图特·卡迪奥瓦苏莱雷·帕里斯·苏德 Classification.Results TRI 组的意见被分类有的更小的 stent 直径((3. | YANG Yue-jin XU Bo CHEN Ji-lin KANG Sheng QIAO Shu-bin QIN Xue-wen YAO Min CHEN Jue WU Yong-jian LIU Hai-bo YUAN Jin-qing YOU Shi-jie LI Jian-jun DAI Jun GAO Run-lin | 2007 | Chinese Medical Journal2007，，7： | 11 |
| 16 | Effects of a Shuangling Fuzheng anticancer preparation on the proliferation of SGC-7901 cells and immune function in a cyclophosphamide-treated murine model显示文摘AIM: To study the inhibitory effects of a Shuangling Fuzheng anticancer preparation (SFAP) on the human gastric cancer cell line SGC-7901 in vitro as well as its immune-modulated effects in a cyclophosphamide-treated murine model. METHODS: MTT experiments and immunocytochemistry ABC experiments were performed for detecting the proliferation of SGC-7901 cells in vitro and protein expression of c-myc. The staphylococcal protein A (SPA) rosette test was utilized for measuring the ratio of T-lymphocyte subsets from peripheral blood in a cyclophosphamide-treated murine model. Enzyme- linked immunosorbant assay (ELISA) was performed for measuring the levels of serum sIL-2R in treated mice, while immunoturbidimetry was used for measuring the levels of immunoglobulins (Ig). RESULTS: SFAP (40-640 mg/L, 48 h) inhibited the proliferation of SGC-7901 cells, and a positive correlation was noted between inhibitory effects and dosage. At a dosage of 160-320 mg/L in cultured cells, the expression of c-myc was decreased. SFAP (50-200 mg/kg) increased the percentage of CD3+ and CD4+ T-lymphocytes, the ratio of CD4/CD8, and the contents of Ig such as IgM, IgG or IgA, but decreased the levels of serum sIL-2R in peripheral blood from cyclophosphamide-treated mice. CONCLUSION: SFAP can inhibit the proliferation of SGC-7901 cells via the c-myc gene. In addition, SFAP can modulat the cellular and humoral immunity in cyclophosphamide-induced immunosuppressed mice. | Hua-Sheng Chen Jue Chen De-Li Cui Yuan-Yuan Zheng Ai-Hua Xu Gang Chen Ling-Chang Jia | 2007 | World Journal of Gastroenterology2007，13，48： | 10 |
| 17 | Comparison of drug eluting stents with bare metal stents in daily practice for bifurcation lesions in Chinese patients显示文摘背景最近,众多的使随机化并且控制的试用在经皮的冠的干预(一种总线标准) 以后关于狭窄的重要减小和症状的复发和临床的结果的改进表明了药 eluting stents (DES ) 的大优点。很少在中国人口为分叉 angioplasty 对在 DES 和赤裸的金属 stents (BMS ) 之间的比较效果被知道。我们从 2004 年 4 月为分叉 lesions.Methods 的治疗把在 DES 和 BMS 之间的住院病人和 7 月的后续结果比作 2005 年 10 月, 291 个中国病人[85.9% 男、吝啬的年龄(57.8 ????????? 剏??? € ?‥ 吗?? | KANG Sheng YANG Yue-jin XU Bo CHEN Ji-lin QIAO Shu-bin YAO Min CHEN Jue WU Yong-jian LIU Hai-bo DAI Jun YUAN Jin-qing LI Jian-jun GAO Run-lin | 2006 | Chinese Medical Journal2006，，14： | 10 |
| 18 | Guilu Erxian Glue(龟鹿二仙胶)Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16INK4a-Rb Signaling Pathway显示文摘Objective To evaluate the effect of Guilu Erxian Glue(龟鹿二仙胶,GEG)on cyclophosphamide(CTX)-induced bone marrow hematopoietic stem cells(HSCs)senescence in mice and explore the underlying mechanism.Methods The H22 liver cancer ascites lump model was established in male Kunming mice by injecting intraperitoneally(i.p.)with 5×10^6/mL H22 cells per mouse.Fifty tumor-bearing mice were divided into the control,model,pifithrin-α,GEG,and GEG+pifithrin-αgroups using a random number table,10 mice in each group.CTX(100 mg/kg i.p.)was administrated to mice from day 1 to day 3(d1–d3)continuously except for the control group.The mice in the pifithrin-α,GEG and GEG+pifithrin-αgroups were treated with pifithrin-α(2.2 mg/(kg·d)i.p.)for 6 consecutive days(d4–d9),GEG(9.5 g/(kg·d)i.p.)for 9 consecutive days(d1–d9),and GEG plus pifithrin-α,respectively.HSCs were collected after 9-d drug treatment.The anti-aging effect of GEG was studied by cell viability,cell cycle,andβ-galactosidase(β-gal)assays.The mRNA and protein expressions of cyclin-dependent kinase 2(CDK2),CDK4,inhibitor of cyclin-dependent kinase 4a encoding the tumor suppressor protein p16^(p16^INK4a),p21^Cip1/Waf1,p53,and phosphorylated retinoblastoma(pRb)were evaluated by quantitative real-time reverse transcription-polymerase chain reaction and semi-quantitative Western blot,respectively.Results Compared with the model group,GEG increased cell viability as well as proliferation(P<0.05 or P<0.01)and reducedβ-gal expression.Furthermore,GEG significantly decreased the expressions of p16^INK4a,p53 and p21^Cip1/Waf1 proteins,and increased the expressions of CDK2,CDK4 and pRb proteins compared with the model group(P<0.05 or P<0.01).Conclusion GEG can alleviate CTX-induced HSCs senescence in mice,and the p16^INK4a-Rb signaling pathway might be the underlying mechanism. | WANG Jue YING Yin-yin CHEN Zhao-hui SHAO Ke-ding ZHANG Wei-ping LIN Sheng-you | 2020 | Chinese Journal of Integrative Medicine2020，26，11： | 10 |
| 19 | Carbon foam with microporous structure for high performance symmetric potassium dual-ion capacitor显示文摘A novel carbon foam with microporous structure(CFMS),with the advantages of a simple fabrication process,low energy consumption,large specific surface area and high conductivity,has been prepared by a facile one-step carbonization.In addition,the carbon foam possesses suitable interlayer spacing in short range which is flexible to accommodate the deformation of carbon layer caused by the ion insertion and deinsertion at the charge and discharge state.Furthermore,a low cost carbon-based symmetric potassium dual-ion capacitor(PDIC),which integrates the virtues of potassium ion capacitors and dual-ion batteries,is successfully established with CFMS as both the battery-type cathode and the capacitor-type anode.PDIC displays a superior rate performance,an ultra-long cycle life(90%retention after 10000 cycles),and a high power density of 7800 W kg^-1 at an energy density of 39Whkg^-1.The PDIC also exhibits excellent ultrafast charge and slow discharge properties,with a full charge in just 60 s and a discharge time of more than 3000 s. | Yanhong Feng Suhua Chen Jue Wang Bingan Lu | 2020 | Journal of Energy Chemistry2020，29，4： | 10 |
| 20 | Follow-up Study of Three Cognitive Potentials of Depression and Anxiety Disorders显示文摘 | XIAO Ze-ping CHEN Xing-shi ZHANG Ming-dao LOU Fei-ying CHEN Jue | 2005 | 上海第二医科大学学报2005，25，9： | 10 |
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