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| 1 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 2 | Resource utilization of solid waste carbide slag:a brief review of application technologies in various scenes显示文摘China is the largest producer and consumer of calcium carbide in the world.The calcium carbide industry is an indispensable industry to support the basic life of people.The huge production capacity of calcium carbide is accompanied by a large number of solid waste carbide slag.Due to the immature treatment technology of carbide slag,a large number of carbide slag are stacked on-site,resulting in land occupation,air-drying,easy take-off ash,and pollution of the environment and water resources.In China,calcium carbide is mainly used to produce acetylene and further utilized,80%of which is used to produce polyvinyl chloride(PVC).A large amount of carbide slag is not used,while only a small part is used in the traditional building materials industry,flue gas desulfurization,sewage treatment,etc.,however,the economic benefits are poor.Therefore,converting the solid waste carbide slag produced by the calcium carbide industry into high value-added CaCO3,CaCl2,CaSO4 whiskers,etc.has become a potential way to expand the development field of the calcium carbide industry and is environmentally friendly.This paper focuses on summarizing the traditional and emerging high value-added utiliza-tion technologies of carbide slag,and then introduces the application research of carbide slag in carbon emission reduction.Finally,the defects of these technologies are summarized and further research directions are prospected.This study provides basic guidance for the diversified development of efficient resource utilization of carbide slag.Graphical abstract Diversified development of calcium carbide industry,resource utilization of solid waste carbide slag and its application of carbon emission reduction have been fully reviewed. | Hongxia Wang Wanyi Xu Maimoona Sharif Guangxu Cheng Zaoxiao Zhang | 2022 | Waste Disposal and Sustainable Energy2022，4，1： | 3 |
| 3 | Unexpected fast radical production emerges in cool seasons:implications for ozone pollution control显示文摘Ozone is a crucial air pollutant that damages human health and vegetation.As it is related to the photo-oxidation of the nitrogen oxides and volatile organic compounds,the summertime reduction of these precursors is the primary focus of current ozone mitigation strategies.During ozone pollution episodes in eastern China,an observed accumulation of daily total oxidants(O_(x)=NO_(2)+O_(3))in cool seasons(spring and autumn:60 ppb and winter 40 ppb)is comparable to that in summer(60 ppb),indicating fast photochemical production of secondary pollutants including ozone over the year.Unrecognized fast radical primary productions are found to counteract the increased termination of hydroxyl radical and unfavorable meteorological conditions to maintain the rapid total oxidant formations in cool seasons.Elucidating and regulating the primary radical sources may be critical for the secondary air pollution control in cool seasons. | Hongli Wang Yanhui Liu Xiaorui Chen Yaqin Gao Wanyi Qiu Shengao Jing Qian Wang Shengrong Lou Peter MEdwards Cheng Huang Keding Lu | 2022 | National Science Open2022，1，2： | 2 |
| 4 | Direct control of store-operated calcium channels by ultrafast laser显示文摘Ca^(2+) channels are essential to cell birth,life,and death.They can be externally activated by optogenetic tools,but this requires robust introduction of exogenous optogenetic genes for expression of photosensitive proteins in biological systems.Here we present femtoSOC,a method for direct control of Ca^(2+)channels solely by ultrafast laser without the need for optogenetic tools or any other exogenous reagents.Specifically,by focusing and scanning wavelength-tuned low-power femtosecond laser pulses on the plasma membrane for multiphoton excitation,we directly induced Ca^(2+) influx in cultured cells.Mechanistic study reveals that photoexcited flavins covalently bind cysteine residues in Orai1 via thioether bonds,which facilitates Orai1 polymerization to form store-operated calcium channels(SOCs)independently of STIM1,a protein generally participating in SOC formation,enabling all-optical activation of Ca^(2+) influx and downstream signaling pathways.Moreover,we used femtoSOC to demonstrate direct neural activation both in brain slices in vitro and in intact brains of living mice in vivo in a spatiotemporal-specific manner,indicating potential utility of femtoSOC. | Pan Cheng Xiaoying Tian Wanyi Tang Juan Cheng Jin Bao Haipeng Wang Sisi Zheng Youjun Wang Xunbin Wei Tunan Chen Hua Feng Tian Xue Keisuke Goda Hao He | 2021 | Cell Research2021，31，7： | 2 |
| 5 | The role of HER2 in cancer therapy and targeted drug delivery 显示文摘 | Tai Wanyi Rubi Mahato Cheng Kun | 2010 | Journal of Controlled Release2010，146，3： | 1 |
| 6 | Kun Prodrugs for improving tumor targetability and efficiency 显示文摘 | Mahato R Tai Wanyi Cheng | 2011 | Adv Drug Deliv Rev2011，63，8： | 1 |
| 7 | Adsorption Mechanism of Composite Whisker on Copper Ions and Lead Ions显示文摘 | LIU Juan XUE Wenjing BAO Yongchao CHENG Wanyi | 2018 | Chemical Research in Chinese Universities2018，34，5： | 1 |
| 8 | The role of HER2 in cancer therapy and targeted drug delivery显示文摘 | Wanyi Tai Rubi Mahato Kun Cheng | 2010 | Journal of Controlled Release2010，，3： | 1 |
| 9 | Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies显示文摘Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders. | Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu Chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang Bi Wanyi Pan Jianjun Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
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