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| 1 | Abscisic Acid-mediated Epigenetic Processes in Plant Development and Stress Responses显示文摘Abscisic acid (ABA) regulates diverse plant processes, growth and development under non-stress conditions and plays a pivotal role in abiotic stress tolerance. Although ABA-regulated genetic processes are well known, recent discoveries reveal that epigenetic processes are an integral part of ABA-regulated processes. Epigenetic mechanisms, namely, histone modifications and cytosine DNA methylation-induced modification of genome give rise to epigenomes, which add diversity and complexity to the genome of organisms. Histone monoubiquitination appears to regulate ABA levels in developing seeds through histone H2B monoubiquitination. ABA and H2B ubiquitination dependent chromatin remodeling regulate seed dormancy. Transcription factor networks necessary for seed maturation are repressed by histone deacetylases (HDACs)-dependent and PICKLE chromatin remodeling complexes (CRCs), whereas ABA induces the expression of these genes directly or through repression of HDACs. Abiotic stress-induced ABA regulates stomatal response and stress-responsive gene expression through HDACs and HOS15-dependent histone deacetylation, as well as through the ATP-dependent SWITCH/SUCROSE NONFERMENTING CRC. ABA also probably regulates the abiotic stress response through DNA methylation and short interfering RNA pathways. Further studies on ABA-regulated epigenome will be of immense use to understand the plant development, stress adaptation and stress memory. | Viswanathan Chinnusamy Zhizhong Gong Jian-Kang Zhu | 2008 | Journal of Integrative Plant Biology2008，50，10： | 43 |
| 2 | RNA-directed DNA methylation and demethylation in plants显示文摘RNA-directed DNA methylation (RdDM) is a nuclear process in which small interfering RNAs (siRNAs) direct the cytosine methylation of DNA sequences that are complementary to the siRNAs. In plants, double stranded-RNAs (dsRNAs) generated by RNA-dependent RNA polymerase 2 (RDR2) serve as precursors for Dicer-like 3 dependent biogenesis of 24-nt siRNAs. Plant specific RNA polymerase IV (Pol IV) is presumed to generate the initial RNA transcripts that are substrates for RDR2. siRNAs are loaded onto an argonaute4-containing RISC (RNA-induced silencing complex) that targets the de novo DNA methyltransferase DRM2 to RdDM target loci. Nascent RNA transcripts from the target loci are generated by another plant-specific RNA polymerase, Pol V, and these transcripts help recruit com- plementary siRNAs and the associated RdDM effector complex to the target loci in a transcrip- tion-coupled DNA methylation process. Small RNA binding proteins such as ROS3 may direct tar- get-specific DNA demethylation by the ROS1 family of DNA demethylases. Chromatin remodeling en- zymes and histone modifying enzymes also participate in DNA methylation and possibly demethylation. One of the well studied functions of RdDM is transposon silencing and genome stability. In addition, RdDM is important for paramutation, imprinting, gene regulation, and plant development. Lo- cus-specific DNA methylation and demethylation, and transposon activation under abiotic stresses suggest that RdDM is also important in stress responses of plants. Further studies will help illuminate the functions of RdDM in the dynamic control of epigenomes during development and environmental stress responses. | CHINNUSAMY Viswanathan | 2009 | Science China(Life Sciences)2009，52，4： | 22 |
| 3 | Studies on the effect of weld defect on the fatigue behavior of welded structures显示文摘Structural integrity isstated as the science and technology of margin between safety and disaster. Systematic prediction of structural integrity of critical structures such ascombustion chambers,pressure vessels,nuclear reactor components,boilers etc.,ensures the human safety,environmental protection,and the economical considerations.The present work aims at prediction of fatigue behaviour of symmetric structures like pressure vessels in the presence of common welding defects such as lack of fusion( LOF),lack of penetration( LOP) and porosity.A ring type specimen which replicates the stress pattern in thepressure vessel is considered for the study of severity of weld imperfections. Initial dimensions of weld defects are arrived by performing NDT inspection.Crack growth analysis is carried out to determine the remaining life of the welded joint with defects. | Ramu Murugan Prabhu Raja Venugobal Thyla Pudukkarai Ramaswami Sathiskumar Jothi Somu Chinnusamy | 2018 | China Welding2018，27，1： | 12 |
| 4 | Cold stress regulation of gene expression in plants显示文摘 | Viswanathan Chinnusamy Jianhua Zhu Jian-Kang Zhu | 2007 | Trends in Plant Science2007，，10： | 4 |
| 5 | In Silico Characterization and Homology Modeling of Thylakoidbound Ascorbate Peroxidase from a Drought Tolerant Wheat Cultivar显示文摘Ascorbate peroxidase,a haem protein (EC 1.11.1.11),efficiently scavenges hydrogen peroxide (H2O2) in cytosol and chloroplasts of plants.In this study,a fulllength coding sequence of thylakoid-bound ascorbate peroxidase cDNA (TatAPX) was cloned from a drought tolerant wheat cultivar C306.Homology modeling of the TatAPX protein was performed by using the template crystal structure of chloroplastic ascorbate peroxidase from tobacco plant (PDB: 1IYN).The model structure was further refined by molecular mechanics and dynamic methods using various tools such as PROCHECK,ProSA and Verify3D.The predicted model was then tested for docking with H2O2,the substrate for TatAPX enzyme.The results revealed that Arg233 and Glu255 in the predicted active site of the enzyme are two important amino acid residues responsible for strong hydrogen bonding affinity with H2O2,which might play an important role in scavenging of H2O2 from the plant system. | A. Katiyar S.K. Lenka K. Lakshmi V. Chinnusamy K.C. Bansal | 2009 | Genomics, Proteomics & Bioinformatics2009，7，4： | 3 |
| 6 | Reply to: Re: “NOTES: Where have we been and where are we going” (2008; 22(5):1143–1145) and “Transvaginal endoscopic appendectomy in humans: a unique approach to NOTES, world’s first” (2008; 22(5):1343–1347)显示文摘 | Chinnusamy Palanivelu Muthukumaran Rangarajan | 2009 | Surgical Endoscopy2009，，3： | 2 |
| 7 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 8 | Understanding and improvingsalt tolerance in plants显示文摘 | Chinnusamy V Jagendorf A Zhu J K | 2005 | Crop Science2005，45，： | 1 |
| 9 | In vitro reconstitution of an abscisic acid signalling pathway显示文摘 | FUJII H CHINNUSAMY V RODRIGUES A RUBIO S AATONI R PARK S Y CUTLER S R SHEEN J ROTRIGUES P L ZHU J K | 2009 | Nature2009，462，： | 1 |
| 10 | Understandingand improving salt tolerance in plants显示文摘 | CHINNUSAMY V JAGENDORF A ZHU J K | 2005 | Crop Science2005，45，： | 1 |
| 11 | ICE1 : aregulator of cold-induced transcription and freezingtolerance in Arabidopsis显示文摘 | Chinnusamy V Ohta M Kanrar S | 2003 | Genes and Development2003，17，： | 1 |
| 12 | ICEI: a regulator of cold- induced transcriptome and freezing tolerance in Arabidopsis显示文摘 | Chinnusamy V Ohta M Kanrar S | 2003 | Genes & Development2003，17，8： | 1 |
| 13 | ICE1: A regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis 显示文摘 | Chinnusamy V Ohta M Kanrar S | 2002 | Genes Dev2002，17，： | 1 |
| 14 | Cold stress regulation of gene expression in plants显示文摘 | Chinnusamy V Zhu J Zhu J K | 2007 | Trends in Plant Science2007，12，10： | 1 |
| 15 | Integrated nutrient supply system of linked components in lowland integrated farming system显示文摘 | Jayanthi C Balusamy M Chinnusamy C | 2003 | Indian Journal of Agronomy2003，48，4： | 1 |
| 16 | Salt stress signaling and mechanisms of plant salt tolerance 显示文摘 | Viswanathan Chinnusamy Zhu Jiankang | 2006 | Genetic Engineering2006，27，： | 1 |
| 17 | Cold stress regulation of gene expression in plants显示文摘 | CHINNUSAMY V ZHU J ZHU J K | 2007 | Trends Plant Sci2007，12，： | 1 |
| 18 | Understanding and improving salt tolerance in plants显示文摘 | Chinnusamy V Jagendorf A Zhu JK | 2005 | Crop Sci2005，45，： | 1 |
| 19 | Epigenetic regulation of stress responses in plants显示文摘 | Chinnusamy V Zhu J K | 2009 | Current opinion in plant biology2009，12，2： | 1 |
| 20 | In vitro re- constitution of an abscisic acid signalling pathway 显示文摘 | Fujii H Chinnusamy V Rodrigues A | 2009 | Nature2009，462，7273： | 1 |
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