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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells显示文摘 | Kim Y A Choi B T Lee Y T | 2004 | Oncol Rep2004，11，2： | 1 |
| 3 | A novel startup scheme of stator-flux-oriented vector-controlled induction motor drive without torque jerk显示文摘 | Chun T W Choi M K Bose B K | 2003 | IEEE Transactions on Industry Applications2003，39，3： | 1 |
| 4 | Trophic cascades in a formerly cod-Dominated ecosystem 显示文摘 | Frank K T Petrie B Choi J S | 2005 | Science2005，308，10： | 1 |
| 5 | A sliding mode control of a full-car ER suspension system via HILS显示文摘 | Choi S B Choi Y T Park D W | 2000 | Journal of Dynamics Measurement and Control ASME2000，122，1： | 1 |
| 6 | New Frame Rate Up-Conversion Using Bi-Directional Motion Estimation显示文摘 | CHOI B T LEE S H KO S J | 2000 | IEEE Transactions on Consumer and Electronics2000，46，3： | 1 |
| 7 | Bayesian variable sampling plans for the exponential distribution with uniformly dis- tributed random censoring 显示文摘 | LAM Y CHOY S T B | 1995 | Journal of Statistical Planning and Inference1995，47，3： | 1 |
| 8 | Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood-brain barrier using focused ultrasound and microbubhles显示文摘 | Baseri B Choi J J Deffieux T | 2012 | Phys Med Biol2012，57，7： | 1 |
| 9 | Nano-indentation of copper thin films on silicon substrates显示文摘 | Suresh S Nieh T G Choi B W | | 0，，09： | 1 |
| 10 | Lack of fibulin - 3 causes early aging and herniation but not macular degeneration in mice 显示文摘 | McLaughlin PJ Bakall B Choi J Liu Z Sasaki T Davis EC Marmorstein AD Marmorstein LY | 2007 | Human Molecular Genetics2007，16，24： | 1 |
| 11 | A phase Ⅱ trial of paclitaxel (T) and carboplatin (C) for advanced gastric cancer refractory to 5-fluorouracil(F) and cisplatin/heptaplatin (P)显示文摘 | Ryoo B K Kim T W Choi S J | 2001 | Proc Am Soc Clin Oncol2001，19，12： | 1 |
| 12 | PIL5,a phytochrome-interacting bHLH protein,regulates gibberellin responsiveness by binding directly to the GAI and RGA promoters in Arabidopsis seeds显示文摘 | Oh E Yamaguchi S Hu J Yusuke J Jung B Paik I Lee H S Sun T Kamiya Y Choi G | 2007 | The Plant Cell2007，19，4： | 1 |
| 13 | Decreased expression of p12 is associated with more advanced tumor invasion in human gastric cancer tissues显示文摘 | Choi M G Sohn T S Park S B | 2009 | Eur Surg Res2009，42，4： | 1 |
| 14 | Control Characteristics of a Continuously Variable ER Damper显示文摘 | Choi S B Choi Y T Chang E G | 1998 | Mechatronics1998，，8： | 1 |
| 15 | Control of catenation in Cu TATB-n metal-organic frameworks by sonochemical synthesis and its effect on CO2adsorption显示文摘 | Kim J Yang S T Choi S B | 2011 | J Mater Chem2011，21，： | 1 |
| 16 | ASliding Mede Control of a Fullcar Electrorheological Suspension System via Hardware-in-the-loop Simulation显示文摘 | Choi S B Choi Y T Park D W | 2000 | Journal of Dynamic Systems Measurement and Control2000，122，1： | 1 |
| 17 | Color emission and dielectric properties of Eu-doped Gd2O3 gate oxide thin films显示文摘 | Choi S Park B Y Ahn T Kim J Y Hong C S Yi M H Jung H K | | 0，，： | 1 |
| 18 | A survey of the Brassica rapa genome by BAC-end sequence analysis and comparison with Arabidopsis thaliana显示文摘 | Hong C P Plaha P Koo D H Yang T J Choi S R Lee Y K Uhm T Bang J W Edwards D Bancroft Ⅰ Park B S Lee J Lim Y P | | 0，，： | 1 |
| 19 | Notchl signaling in F1ZZ1 induction of myofibroblast differentiation显示文摘 | Liu T Hu B Choi YY | 2009 | AmJ Pathol2009，174，5： | 1 |
| 20 | Cupping for hypertension: a systematic review显示文摘 | Lee M S Choi T Y Shin B C Kim J l Nam S S | 2010 | Clin Exp Hypertens2010，32，： | 1 |
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