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| 1 | 原发灶切除在无症状的、同时性的、转移灶不可切除的结直肠癌患者中的作用:一项多中心随机对照试验显示文摘目的:我们在同时性的、转移灶不可切除的无症状Ⅳ期结直肠癌患者中,评估接受原发灶切除术(primary tumor resection,PTR)续贯化疗的患者相比接受单纯化疗的患者的生存优势。方法:这是一项开放的前瞻性随机对照试验(ClnicalTrials.gov注册号:NCT01978249)。从2013年5月至2016年4月,在12所三级医院中将48例诊断为转移灶不可切除的、原发灶无症状的结直肠癌患者按1:1比例进行随机化分组,其中PTR组26例、化疗组22例。主要终点是两年总生存率,次要终点为与原发灶、PTR相关的并发症发生率以及转变为可切除状态的转化率。 | 卓长华 陈功 PARK E J BAEK J H CHOI G S | 2020 | 结直肠肛门外科2020，26，5： | 8 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | The quality of reconstructed 3D images in mutidetector-row helical CT: experimental study involving scan parameters显示文摘 | Shin J H Lee H K Choi C G | 2002 | Korean J Radiol2002，3，1： | 2 |
| 4 | All-optical clock recovery from NRZ data with simple NRZ-to-PRZ converter based on self-modulation of semiconductor optical amplifier显示文摘 | Lee H J Kim H G Choi J Y | 1999 | Electronics Letters1999，35，12： | 2 |
| 5 | Evaluation of seismic performance of multistory building structures based on the equivalent responses 显示文摘 | LEE D G CHOI W H CHEONG M C | 2006 | Engineering Structures2006，28，6： | 1 |
| 6 | A generalized ordering and recovery policy for reusable items显示文摘 | CHOI DW HWANG H KOH S G | 2007 | European Journal of Operational Research2007，182，2： | 1 |
| 7 | Antifungal activity of the methanol extract of Myristica malabarica fruit rinds and the active ingredients malabaricones against phytopathogenic fungi 显示文摘 | Choi H N Choi J G Jang S K | 2008 | Plant Pathol2008，24，3： | 1 |
| 8 | AtMYB21,a gene encoding a flower-specific transcription factor,is regulated by COP1显示文摘 | Shin B Choi G Yi H | 2002 | The Plant Journal2002，30，1： | 1 |
| 9 | Improvement of 4I11/2→4I13/2 transition rate and thermal stabilities in Er3+-doped TeO2-B2O3-(GeO2)ZnO-K2O Glasses 显示文摘 | Cho D H Choi Y G Kim K H | 2001 | ETRI Joural(S1225-6463)2001，2，4： | 1 |
| 10 | Protective effects of extract with phenolics from Camellia (Camellia japonica) leaf against oxidative stress- induced neurotoxicity显示文摘 | JEONG C H KIM J H CHOI G N | 2010 | Food Sci Biotechnol2010，19，5： | 1 |
| 11 | Relationship be- tween psychological factors and quality of life in subtypes of gastroesophageal reflux disease显示文摘 | Oh J H Kim T S Choi M G | 2009 | Gut Liver2009，3，4： | 1 |
| 12 | Over expression of CD24:association with invasiveness in urothelial carcinoma of bladder显示文摘 | Choi Y L Lee S H Kwon G Y | 2007 | Arch Pathol Lab Med2007，131，2： | 1 |
| 13 | Comparison of AI-Cu-Fe quasierystalline particle reinforced AI composites fabricated by conventional casting and extrusion显示文摘 | Fleury E Lee S M Choi G Kim W T Kim D H | 2001 | J Mater Sci2001，36，： | 1 |
| 14 | Effects of ascorbic acidretention on juice color and pigment stability in blood orange (Citrus sinensis ) juice during refrigerated storage 显示文摘 | Choi M H Kim G H Lee H S | 2002 | Food Research International2002，35，8： | 1 |
| 15 | Curcumin down -regulates the muhidrug- resistance mdrl b genc by inhibiting the PI3K/Akt/ NF kappa B pathway显示文摘 | CHOI B H KIM C G LIM Y | 2008 | Cancer Lett2008，259，： | 1 |
| 16 | Effect of nitrate on the degradation of bisphenol A by UV/H202 and ozone/H2 02 oxi- dation in aqueous solution 显示文摘 | Park C G Choi E S Jeon H W | 2014 | Desalination and Water Treat- ment2014，52，46： | 1 |
| 17 | 显示文摘 | Wang D H Choi D G Park O Ok | 2010 | J Mater Chem2010，20，23： | 1 |
| 18 | Evolution of local structure around manganese in layered LiMnO/upon chemical and electrochemical delithiation/relithiation 显示文摘 | HWANG S J PARK H S CHOY J H CAMPET G | 2000 | Chem Mater2000，12，： | 1 |
| 19 | Development of in situgelling and mucoadhesive acetaminophe liquid suppository 显示文摘 | CHOI H G JUNG J H RYU J M | 1998 | Int J Pharm1998，165，： | 1 |
| 20 | Robust digital Image watermarking method against geometrical attacks显示文摘 | Kim B S Choi J G Park C H | 2003 | Real- Time hnaging2003，9，2： | 1 |
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