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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Tetralogy of Fallot显示文摘 | Christian Apitz Gary D Webb Andrew N Redington | 2009 | 2009 (9699)2009，，9699： | 2 |
| 4 | Inorganic soil amendment effects on sand-Based sports turf media 显示文摘 | Li D Y Joo Y K Christians N E etal | 2000 | Crop Science2000，40，： | 1 |
| 5 | Nutrient require- ment and cycling in energy crops 显示文摘 | Christian D G Riche A B Yates N E | 1997 | Sustainable Agri- culture for Food Energy and Industry1997，2，： | 1 |
| 6 | Herbicidal activity of a hydrolysed corn gluten meal on three grass species under controlled environments显示文摘 | LIU D L CHRISTIANS N E GARBUTT J T | 1994 | J Plant Growth Regut1994，13，： | 1 |
| 7 | Nitrogen, Phosphorus, and potassium effects on quality and growth of Kentucky bluegrass and creeping bentgrass显示文摘 | Christians N E Martain D P Wilkinson J F | 1979 | J Agron1979，71，： | 1 |
| 8 | Field dvices-models and their Realisation显示文摘 | RENE S PETER N CHRISTIAN D | 2002 | Industrial Technology2002，4，： | 1 |
| 9 | Enhancing career development through the career success club显示文摘 | Wessel R D Christian N T Hoff A K | 2003 | Journal of Career Development2003，，29： | 1 |
| 10 | The yield and composition of switchgrass and coastal panic grass grown as a biofuel in Southern England显示文摘 | Christian D Riche A Yates N | 2008 | Bioresource Technology2008，83，： | 1 |
| 11 | Lithium incorporation by V6O13 and related vanadium (+4, +5) oxide cathode materials显示文摘 | MURPHY D W CHRISTIAN P A DISALVO F J CARIDES J N WASZCZAK J V | 1981 | J Electrochemical Society1981，128，10： | 1 |
| 12 | Estimation of ramet production from Miscanthus X giganteus rhizome of different ages显示文摘 | Christian D G 'fates N E Riche A B | 2009 | Ind Crop Prod2009，30，： | 1 |
| 13 | Growth, yield and mineral content of MiscanthusX Giganteus grown as a biofuel for 14 successive harvests显示文摘 | Christian D G Riche A B Yates N E | 2008 | Industrial Crops and Products2008，28，： | 1 |
| 14 | Isolation and identification of root-inhibiting compounds from corn gluten hydrolysate显示文摘 | LIU D L Y CHRISTIANS N E | 1994 | J Plant Growth Regul1994，13，： | 1 |
| 15 | Nitrogen, Phos phorus, and Pastassium effects on qualityand growth of Kentucky bluegrass and Creeping bentgrass显示文摘 | Christians N E Martin D P Wilkinson J F | 1979 | A gronomy Journal1979，71，： | 1 |
| 16 | Evaluating the impact of variable root zone depth on the hydraulic properties of sand-based turf systems显示文摘 | Li D Minner D D Christians N E | 2005 | International Turfgrass Society Research Journal2005，10，： | 1 |
| 17 | Herbicidal Activity of Hydrolyzed Corn Gluten Meal on Three Grass Species under Controlled Environments 显示文摘 | Liu D L Y Christians N E Garbutt J T | 1994 | Plant Growth Regulation1994，13，4： | 1 |
| 18 | Gene expression during cold acclimation in strawberry显示文摘 | CHRISTIAN N D FRANCOIS O MARIO H | 1997 | Plant Cell Physiology1997，38，7： | 1 |
| 19 | Tetralogy of Fallot显示文摘 | Christian Apitz Gary D Webb Andrew N Redington | 2009 | The Lancet2009，，9699： | 1 |
| 20 | Inorganic soil amendment effects on sand based sports turf media显示文摘 | Li D Y Joo Y K Christians N E etal | 2000 | Corp Science2000，40，4： | 1 |
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