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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Prevalence and risk factors for adenomas in the ileal pouch and the afferent loop after restorative proctocolectomy for patients with familial adenomatous polyposis显示文摘 | Elise Pommaret Ariane Vienne Jérémie H. Lefevre Philippe Sogni Christian Florent Beno?t Desaint Yann Parc | 2013 | Surgical Endoscopy2013，，10： | 1 |
| 3 | Abdominal obesi-ty is associated with microalbuminuria and an elevated cardio-vascular risk profile in patients with hypertension 显示文摘 | Martin T Jan Christian R Bobby V | 2009 | VaseHealth Risk Manag2009，5，4： | 1 |
| 4 | Determination of antibiotic residues in manure,soil and surface waters显示文摘 | CHRISTIAN T SCHEIDER R J FRBER H A | 2003 | Acta Hydrochim Hydrobiol2003，31，1： | 1 |
| 5 | Determination of antibiotic residues in manure, soil, and surface waters显示文摘 | Christian T Schneider R J Farber H A | 2003 | Acta Hydroehim Hydrobiol2003，31，1： | 1 |
| 6 | De-termination of antibiotics residues in manure,soil and surface wa-ters显示文摘 | CHRISTIAN T SCHNEIDER R J FVRBER H A | 2003 | Actahydrochim Hydrobiol2003，31，： | 1 |
| 7 | Enhancing career development through the career success club显示文摘 | Wessel R D Christian N T Hoff A K | 2003 | Journal of Career Development2003，，29： | 1 |
| 8 | Determinants of infarct size in reperfusion therapy for acute myocardial infarction显示文摘 | Christian T F Schwartz R S Cibbons R J | 1992 | Circulation1992，86，： | 1 |
| 9 | Rotor Temperature estimation of squirrel-cage induction motors by means of a combined scheme of parameter estimation and a thermal equivalent model显示文摘 | Christian Kral Habetler T G Harley R G | 2004 | IEEE Transactions on Industry Applications2004，，： | 1 |
| 10 | Soluble intercellular adhesion molecule- 1 inhibits MHC- restricted Spcitfic T cell/tumor interaction显示文摘 | Christian T Schmidt R | 1993 | J Immunol1993，151，12： | 1 |
| 11 | Determination of antibi-otic residues in manure, soil, and surface waters显示文摘 | Christian T Schneider R J Farber H A | 2003 | Acta HydrochimicaEt Hydrobiologica2003，31，1： | 1 |
| 12 | The detection of lightning from geostationary orbit显示文摘 | CHRISTIAN H J BLAKESLEC R J GOODMAN S T | 1989 | J Geo Res1989，94，13： | 1 |
| 13 | Effect on growth, survival, and fatty acid composition of Australian red claw crayfish Cherax quadricarinatus fed practical diets with and without supplemental lecithin and/or cholesterol 显示文摘 | Thompson K R Muzinici L A Christian T D | 2003 | World Aquaculture Society2003，34，1： | 1 |
| 14 | Lecithin requirements of juvenile Australian red claw crayfish Cherax quadricarinatus显示文摘 | Thompson K R Muziniei L A Christian T D | 2003 | Aquaculture Nutrition2003，9，4： | 1 |
| 15 | Layer-by-layer growth of Ag on Ag (111) induced by enhanced nucleation: a model study for surfactant-mediated growth 显示文摘 | GEORG R S CHRISTIAN T POELSEMA B | 1993 | Phys Rev Lett1993，71，： | 1 |
| 16 | Estimates of myocardium at risk and collateral flow in acute myocardial infarction using electrocardiographic indexes with comparison to radionuclide and angiographic measures显示文摘 | Christian T Gibbons R Clements I | 1995 | J Am Coll Cardiol1995，26，2： | 1 |
| 17 | Determination of antibiotic residues in manure,soil,and surface water显示文摘 | Christian T Schneider R J Farber H A | 2003 | Acta Hydrochim Hydrobiol2003，31，1： | 1 |
| 18 | Monitoring of integrin-mediated adhesion of human ovarian cancer cells to model protein surfaces by quartz crystal resonators:evaluation in the impedance analysis mode显示文摘 | JING L CHRISTIANE T UTE R | 2005 | Biosensors and Bioelectronics2005，20，7： | 1 |
| 19 | Determination of antibiotics residues in manure,soil,and surface waters 显示文摘 | CHRISTIAN T SCHNEIDER R J FVRBER H A | 2003 | Acta Hydrochim Hydrobiol2003，，31： | 1 |
| 20 | Eearly intrathecal production of interleukin-6 predicts the size of brain lesion in stroke 显示文摘 | Elisabeth T Lars R Christian B | 1995 | Stroke1995，26，： | 1 |
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