|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges显示文摘 | Christians U Schmitz V Schoning W | 2008 | Ther Drug Monit2008，30，2： | 1 |
| 3 | Lithium incorporation by V6O13 and related vanadium (+4, +5) oxide cathode materials显示文摘 | MURPHY D W CHRISTIAN P A DISALVO F J CARIDES J N WASZCZAK J V | 1981 | J Electrochemical Society1981，128，10： | 1 |
| 4 | Lithium incorporation by vanadium pentoxide显示文摘 | MURPHY D W CHRISTIAN P A DISALVO F J WASZCZAK J V | 1979 | Inorg Chem1979，18，： | 1 |
| 5 | High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes显示文摘 | BARBORA V CHRISTIAN W ROBERT S | 2002 | Diabetes2002，51，2： | 1 |
| 6 | OSTalpha-OSTbeta:a major basolateral bile acid and steroid transporter in human intestinal,renal,and biliary epithelia显示文摘 | CHRISTIAN W V LEE J Y | 2005 | Hepatology2005，42，6： | 1 |
| 7 | Activation of AP-1 and nuclear factor-kappaB transcription factors is involved in hydrogen peroxide-induced apoptotic cell death of oligodendroytes 显示文摘 | Ulrich V Michal W Christiane RL | 1999 | Journal of Neurochemistry1999，73，6： | 1 |
| 8 | Coordinating supplier involvement in product development projects: a differentiated coordination typology 显示文摘 | NICOLETTE L CHRISTIAN B ARJAN V W | 2006 | R&D Management2006，，1： | 1 |
| 9 | N - terminal pro - B - type natriuretic peptide levels for dynamic risk stratification of patients with acute coronary syndromes 显示文摘 | Heechen C Christian W Mitrovic V et 81 | 2004 | Circulation2004，110，20： | 1 |
| 10 | Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges显示文摘 | Christians U Schmitz V Sch?ning W Bendrick-Peart J Klawitter J Haschke M | 2008 | Ther Drug Monit2008，30，2： | 1 |
| 11 | Toxieodynamic thera- peutic drog monitoring of immunosuppressants : promises, reality,and challenges显示文摘 | Christians U Sehmitz V Schning W | 2008 | Ther Drug Monit2008，30，2： | 1 |
| 12 | Assessment of potential impacts of agricultural practices on the environment: the AGRO*ECO method显示文摘 | Philippe G Christian B Hayo V W | 2000 | Environmental Assessment Review2000，20，： | 1 |
| 13 | Associated with a worsening ofinsulin sensitivity and predicts the development of type 2 diabetes显示文摘 | Barbora V Christian W Robert S | 2002 | Diabetes2002，5，2： | 1 |
| 14 | Platelets as immune cells bridging inflammation and cardiovascular disease 显示文摘 | Philipp v H Christian W | 2007 | Circulation Research2007，5，19： | 1 |
| 15 | The treat- ment of patients with HIV 显示文摘 | Martin V Sehwarze Zander C Christian W | 2010 | Dtseh Arzteblint2010，107，28： | 1 |
| 16 | The treat- ment of patients with HIV显示文摘 | Martin V Schwarze - zander C Jan - Christian W | 2010 | Dtsch Arzteblint2010，107，2829： | 1 |
| 17 | Supporting taskoriented modeling using interactive UML views 显示文摘 | Christian F J L Martiin A M W Michel R V C | 2005 | Journal of Visual Languages and Computing2005，18，4： | 1 |
| 18 | High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes 显示文摘 | Barbora V Christian W Robert SL | 2002 | Diabetes2002，51，2： | 1 |
| 19 | Toxicodynamic therapeutic drug monitoring of immunosuppressants:promises,reality and challenges显示文摘 | CHRISTIANS U SCHMITZ V SCH?NING W | 2008 | Ther Drug Monit2008，30，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员